Murcko scaffold
Ring system with 4 rings and 26 atoms
13 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 26
- Chemicals
- 13
- With full pages
- 7
Scaffold SMILES
O=C(CSc1nc2c(c(=O)n1-c1ccccc1)SCC2)Nc1ccon1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 13 of 13 chemicals
![N-(5-Methylisoxazol-3-yl)-2-((4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide chemical structure, C18H16N4O3S2, CAS 850915-19-4](/s/YFWOMKCLPRFIKT-UHFFFAOYSA-N.svg)
N-(5-Methylisoxazol-3-yl)-2-((4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
CAS 850915-19-4C18H16N4O3S2
![2-[[3-(4-Methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(5-methyl-1,2-oxazol-3-yl)acetamide chemical structure, C19H18N4O4S2, CAS 850915-63-8](/s/OJMNFYFGJBOFGJ-UHFFFAOYSA-N.svg)
2-[[3-(4-Methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(5-methyl-1,2-oxazol-3-yl)acetamide
CAS 850915-63-8C19H18N4O4S2
![2-((3-(4-Chlorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide chemical structure, C18H15ClN4O3S2, CAS 850915-85-4](/s/YPMZEJOVTCSYIX-UHFFFAOYSA-N.svg)
2-((3-(4-Chlorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide
CAS 850915-85-4C18H15ClN4O3S2
![N-(5-Methyl-1,2-oxazol-3-yl)-2-[[3-(4-nitrophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]acetamide chemical structure, C18H15N5O5S2, CAS 687568-64-5](/s/DNHAWUBRTHGPJX-UHFFFAOYSA-N.svg)
N-(5-Methyl-1,2-oxazol-3-yl)-2-[[3-(4-nitrophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]acetamide
CAS 687568-64-5C18H15N5O5S2
![2-[[3-(4-Bromophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(5-methyl-1,2-oxazol-3-yl)acetamide chemical structure, C18H15BrN4O3S2, CAS 362501-42-6](/s/NZDJSFSNJRIVFU-UHFFFAOYSA-N.svg)
2-[[3-(4-Bromophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(5-methyl-1,2-oxazol-3-yl)acetamide
CAS 362501-42-6C18H15BrN4O3S2
![2-((3-(4-Methoxyphenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide chemical structure, C20H20N4O4S2, CAS 905695-89-8](/s/AXPQSQAUBWUDTB-UHFFFAOYSA-N.svg)
2-((3-(4-Methoxyphenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide
CAS 905695-89-8C20H20N4O4S2
![2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide chemical structure, C18H15FN4O3S2, CAS 362501-65-3](/s/HQYKXJBWUIHTQQ-UHFFFAOYSA-N.svg)
2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide
CAS 362501-65-3C18H15FN4O3S2
![2-((3-(4-Ethoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide chemical structure, C20H20N4O4S2, CAS 362502-05-4](/s/QHVZBTWZVYBUMD-UHFFFAOYSA-N.svg)
2-((3-(4-Ethoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide
CAS 362502-05-4C20H20N4O4S2
![2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide chemical structure, C19H18N4O4S2, CAS 6183-61-5](/s/MTIYGRRHAKTENR-UHFFFAOYSA-N.svg)
2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide
CAS 6183-61-5C19H18N4O4S2
![2-((3-(3-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide chemical structure, C19H18N4O4S2, CAS 877655-75-9](/s/KMCLKQQDANYDQV-UHFFFAOYSA-N.svg)
2-((3-(3-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide
CAS 877655-75-9C19H18N4O4S2
![2-((3-(3,4-Dimethoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide chemical structure, C20H20N4O5S2, CAS 877656-09-2](/s/KGSKJQHZQYURKW-UHFFFAOYSA-N.svg)
2-((3-(3,4-Dimethoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide
CAS 877656-09-2C20H20N4O5S2
![2-((3-(3,5-Dimethylphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide chemical structure, C20H20N4O3S2, CAS 877653-93-5](/s/GZJDNCLUYHPVAO-UHFFFAOYSA-N.svg)
2-((3-(3,5-Dimethylphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide
CAS 877653-93-5C20H20N4O3S2
![N-(5-Methylisoxazol-3-yl)-2-((4-oxo-3-(4-(trifluoromethoxy)phenyl)-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide chemical structure, C19H15F3N4O4S2, CAS 877654-53-0](/s/GPRZPFJJLVFDHL-UHFFFAOYSA-N.svg)
N-(5-Methylisoxazol-3-yl)-2-((4-oxo-3-(4-(trifluoromethoxy)phenyl)-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
CAS 877654-53-0C19H15F3N4O4S2
Related scaffolds
Same ring framework with different atoms or bond orders
