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Murcko scaffold

1-Benzyldihydropyrimidine-2,4(1H,3H)-dione scaffold

24 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
24
With full pages
8
Scaffold SMILES

O=C1CCN(Cc2ccccc2)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzyldihydropyrimidine-2,4(1H,3H)-dione page
Murcko scaffold O=C1CCN(Cc2ccccc2)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

Hydrouracil, 1-(p-butoxybenzyl)- chemical structure, C15H20N2O3, CAS 4010-74-6
Hydrouracil, 1-(p-butoxybenzyl)-
CAS 4010-74-6C15H20N2O3
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-methoxyphenyl)methyl)- chemical structure, C12H14N2O3, CAS 55383-98-7
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-methoxyphenyl)methyl)-
CAS 55383-98-7C12H14N2O3
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-propoxyphenyl)methyl)- chemical structure, C14H18N2O3, CAS 55384-00-4
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-propoxyphenyl)methyl)-
CAS 55384-00-4C14H18N2O3
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-(1-methylethoxy)phenyl)methyl)- chemical structure, C14H18N2O3, CAS 55384-01-5
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-(1-methylethoxy)phenyl)methyl)-
CAS 55384-01-5C14H18N2O3
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-(2-methylpropoxy)phenyl)methyl)- chemical structure, C15H20N2O3, CAS 55384-02-6
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-(2-methylpropoxy)phenyl)methyl)-
CAS 55384-02-6C15H20N2O3
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-methoxyphenyl)methyl)-5-methyl- chemical structure, C13H16N2O3, CAS 62554-10-3
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-methoxyphenyl)methyl)-5-methyl-
CAS 62554-10-3C13H16N2O3
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-ethoxyphenyl)methyl)-5-methyl- chemical structure, C14H18N2O3, CAS 62554-11-4
2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-ethoxyphenyl)methyl)-5-methyl-
CAS 62554-11-4C14H18N2O3
4-Hydroxy-5-methyl-1-((4-propoxyphenyl)methyl)-5,6-dihydropyrimidin-2(1H)-one chemical structure, C15H20N2O3, CAS 62554-12-5
4-Hydroxy-5-methyl-1-((4-propoxyphenyl)methyl)-5,6-dihydropyrimidin-2(1H)-one
CAS 62554-12-5C15H20N2O3
4-Hydroxy-5-methyl-1-((4-((propan-2-yl)oxy)phenyl)methyl)-5,6-dihydropyrimidin-2(1H)-one chemical structure, C15H20N2O3, CAS 62554-13-6
4-Hydroxy-5-methyl-1-((4-((propan-2-yl)oxy)phenyl)methyl)-5,6-dihydropyrimidin-2(1H)-one
CAS 62554-13-6C15H20N2O3
1-((4-Butoxyphenyl)methyl)-4-hydroxy-5-methyl-5,6-dihydropyrimidin-2(1H)-one chemical structure, C16H22N2O3, CAS 62554-14-7
1-((4-Butoxyphenyl)methyl)-4-hydroxy-5-methyl-5,6-dihydropyrimidin-2(1H)-one
CAS 62554-14-7C16H22N2O3
1-((4-Ethoxyphenyl)methyl)dihydro-2,4(1H,3H)-pyrimidinedione chemical structure, C13H16N2O3, CAS 55383-99-8
1-((4-Ethoxyphenyl)methyl)dihydro-2,4(1H,3H)-pyrimidinedione
CAS 55383-99-8C13H16N2O3
1-(2,4-Dichlorobenzyl)dihydropyrimidine-2,4(1H,3H)-dione chemical structure, C11H10Cl2N2O2, CAS 4020-18-2
1-(2,4-Dichlorobenzyl)dihydropyrimidine-2,4(1H,3H)-dione
CAS 4020-18-2C11H10Cl2N2O2
1-Benzyl-5-methyldihydropyrimidine-2,4(1H,3H)-dione chemical structure, C12H14N2O2, CAS 4010-63-3
1-Benzyl-5-methyldihydropyrimidine-2,4(1H,3H)-dione
CAS 4010-63-3C12H14N2O2
1-Benzyldihydropyrimidine-2,4(1H,3H)-dione chemical structure, C11H12N2O2, CAS 716-99-4
1-Benzyldihydropyrimidine-2,4(1H,3H)-dione
CAS 716-99-4C11H12N2O2
1-Benzyl-5-bromo-1,3-diazinane-2,4-dione chemical structure, C11H11BrN2O2, CAS 3959-45-3
1-Benzyl-5-bromo-1,3-diazinane-2,4-dione
CAS 3959-45-3C11H11BrN2O2
1-Benzyl-5-bromo-6-methyl-1,3-diazinane-2,4-dione chemical structure, C12H13BrN2O2, CAS 6635-62-7
1-Benzyl-5-bromo-6-methyl-1,3-diazinane-2,4-dione
CAS 6635-62-7C12H13BrN2O2
1-Benzyl-2,4-dioxo-1,3-diazinane-5-carboximidamide chemical structure, C12H14N4O2, CAS 477853-47-7
1-Benzyl-2,4-dioxo-1,3-diazinane-5-carboximidamide
CAS 477853-47-7C12H14N4O2
1-(4-Methylbenzyl)dihydropyrimidine-2,4(1H,3H)-dione chemical structure, C12H14N2O2, CAS 4020-19-3
1-(4-Methylbenzyl)dihydropyrimidine-2,4(1H,3H)-dione
CAS 4020-19-3C12H14N2O2
1-((4-Bromophenyl)methyl)-1,3-diazinane-2,4-dione chemical structure, C11H11BrN2O2, CAS 1503602-97-8
1-((4-Bromophenyl)methyl)-1,3-diazinane-2,4-dione
CAS 1503602-97-8C11H11BrN2O2
1-(4-Fluorobenzyl)dihydropyrimidine-2,4(1H,3H)-dione chemical structure, C11H11FN2O2, CAS 1263216-75-6
1-(4-Fluorobenzyl)dihydropyrimidine-2,4(1H,3H)-dione
CAS 1263216-75-6C11H11FN2O2
3-((2,4-Dioxotetrahydropyrimidin-1(2H)-yl)methyl)-4-methoxybenzoic acid chemical structure, C13H14N2O5, CAS 2633725-24-1
3-((2,4-Dioxotetrahydropyrimidin-1(2H)-yl)methyl)-4-methoxybenzoic acid
CAS 2633725-24-1C13H14N2O5
1-[(3,4-Dichlorophenyl)methyl]-1,3-diazinane-2,4-dione chemical structure, C11H10Cl2N2O2, CAS 4010-64-4
1-[(3,4-Dichlorophenyl)methyl]-1,3-diazinane-2,4-dione
CAS 4010-64-4C11H10Cl2N2O2
5-Chloro-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyldihydropyrimidine-2,4(1H,3H)-dione chemical structure, C13H11ClF4N2O2, CAS 1956384-95-4
5-Chloro-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyldihydropyrimidine-2,4(1H,3H)-dione
CAS 1956384-95-4C13H11ClF4N2O2
1-(3-(2-Hydroxyethyl)benzyl)dihydropyrimidine-2,4(1H,3H)-dione chemical structure, C13H16N2O3, CAS 2633725-22-9
1-(3-(2-Hydroxyethyl)benzyl)dihydropyrimidine-2,4(1H,3H)-dione
CAS 2633725-22-9C13H16N2O3