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Murcko scaffold

Ring system with 4 rings and 25 atoms

31 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
31
With full pages
7
Scaffold SMILES

O=C(CSc1nnc2scc(-c3ccccc3)n12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc2scc(-c3ccccc3)n12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

2-((5-(4-Chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(4-fluorophenyl)acetamide chemical structure, C18H12ClFN4OS2, CAS 667912-72-3
2-((5-(4-Chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(4-fluorophenyl)acetamide
CAS 667912-72-3C18H12ClFN4OS2
N-(3-Acetylphenyl)-2-((5-(4-chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide chemical structure, C20H15ClN4O2S2, CAS 667912-74-5
N-(3-Acetylphenyl)-2-((5-(4-chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide
CAS 667912-74-5C20H15ClN4O2S2
N-(3-Acetylphenyl)-2-[(5-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)sulfanyl]acetamide chemical structure, C20H16N4O2S2, CAS 667912-80-3
N-(3-Acetylphenyl)-2-[(5-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)sulfanyl]acetamide
CAS 667912-80-3C20H16N4O2S2
N-(4-Chlorophenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide chemical structure, C18H13ClN4OS2, CAS 671199-68-1
N-(4-Chlorophenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide
CAS 671199-68-1C18H13ClN4OS2
N-(4-Ethoxyphenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide chemical structure, C20H18N4O2S2, CAS 671199-49-8
N-(4-Ethoxyphenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide
CAS 671199-49-8C20H18N4O2S2
N-(4-Methoxyphenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide chemical structure, C19H16N4O2S2, CAS 671199-51-2
N-(4-Methoxyphenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide
CAS 671199-51-2C19H16N4O2S2
2-((5-Phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(p-tolyl)acetamide chemical structure, C19H16N4OS2, CAS 671199-54-5
2-((5-Phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(p-tolyl)acetamide
CAS 671199-54-5C19H16N4OS2
2-[(5-Phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C19H13F3N4OS2, CAS 671199-66-9
2-[(5-Phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 671199-66-9C19H13F3N4OS2
2-((5-(4-Chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(p-tolyl)acetamide chemical structure, C19H15ClN4OS2, CAS 671199-89-6
2-((5-(4-Chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(p-tolyl)acetamide
CAS 671199-89-6C19H15ClN4OS2
2-((5-(4-Chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(m-tolyl)acetamide chemical structure, C19H15ClN4OS2, CAS 671200-04-7
2-((5-(4-Chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(m-tolyl)acetamide
CAS 671200-04-7C19H15ClN4OS2
N-(4-Methoxyphenyl)-2-((5-(p-tolyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide chemical structure, C20H18N4O2S2, CAS 727689-41-0
N-(4-Methoxyphenyl)-2-((5-(p-tolyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide
CAS 727689-41-0C20H18N4O2S2
N-(4-Fluorophenyl)-2-[[5-(4-methylphenyl)-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl]acetamide chemical structure, C19H15FN4OS2, CAS 727689-43-2
N-(4-Fluorophenyl)-2-[[5-(4-methylphenyl)-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl]acetamide
CAS 727689-43-2C19H15FN4OS2
N-(3-Chloro-4-fluorophenyl)-2-{[5-(4-methylphenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl]sulfanyl}acetamide chemical structure, C19H14ClFN4OS2, CAS 727689-44-3
N-(3-Chloro-4-fluorophenyl)-2-{[5-(4-methylphenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl]sulfanyl}acetamide
CAS 727689-44-3C19H14ClFN4OS2
N-(3-Methylphenyl)-2-{[5-(4-methylphenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl]sulfanyl}acetamide chemical structure, C20H18N4OS2, CAS 690645-32-0
N-(3-Methylphenyl)-2-{[5-(4-methylphenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl]sulfanyl}acetamide
CAS 690645-32-0C20H18N4OS2
Methyl 4-[({[5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl}acetyl)amino]benzoate chemical structure, C21H18N4O3S2, CAS 496023-60-0
Methyl 4-[({[5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl}acetyl)amino]benzoate
CAS 496023-60-0C21H18N4O3S2
N-(4-Fluorophenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide chemical structure, C18H13FN4OS2, CAS 671199-61-4
N-(4-Fluorophenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide
CAS 671199-61-4C18H13FN4OS2
N-(3-Methoxyphenyl)-2-({5-phenyl-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl}sulfanyl)acetamide chemical structure, C19H16N4O2S2, CAS 671199-52-3
N-(3-Methoxyphenyl)-2-({5-phenyl-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl}sulfanyl)acetamide
CAS 671199-52-3C19H16N4O2S2
N-(4-(tert-Butyl)phenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide chemical structure, C22H22N4OS2, CAS 671199-56-7
N-(4-(tert-Butyl)phenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide
CAS 671199-56-7C22H22N4OS2
N-(2-Fluorophenyl)-2-[(5-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)sulfanyl]acetamide chemical structure, C18H13FN4OS2, CAS 671199-65-8
N-(2-Fluorophenyl)-2-[(5-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)sulfanyl]acetamide
CAS 671199-65-8C18H13FN4OS2
N-(3-Chloro-4-fluorophenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide chemical structure, C18H12ClFN4OS2, CAS 671199-67-0
N-(3-Chloro-4-fluorophenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide
CAS 671199-67-0C18H12ClFN4OS2
2-((5-(4-Chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(4-methoxyphenyl)acetamide chemical structure, C19H15ClN4O2S2, CAS 671199-88-5
2-((5-(4-Chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(4-methoxyphenyl)acetamide
CAS 671199-88-5C19H15ClN4O2S2
2-{[5-(4-Chlorophenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl]sulfanyl}-N-(2-fluorophenyl)acetamide chemical structure, C18H12ClFN4OS2, CAS 671199-96-5
2-{[5-(4-Chlorophenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl]sulfanyl}-N-(2-fluorophenyl)acetamide
CAS 671199-96-5C18H12ClFN4OS2
2-((5-(4-Chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide chemical structure, C19H12ClF3N4OS2, CAS 671199-97-6
2-((5-(4-Chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide
CAS 671199-97-6C19H12ClF3N4OS2
N-(3-Chloro-4-fluorophenyl)-2-((5-(4-chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide chemical structure, C18H11Cl2FN4OS2, CAS 671199-98-7
N-(3-Chloro-4-fluorophenyl)-2-((5-(4-chlorophenyl)thiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide
CAS 671199-98-7C18H11Cl2FN4OS2