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Murcko scaffold

RefChem:357196 scaffold

5 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
5
With full pages
3
Scaffold SMILES

O=c1[nH]c(=S)[nH]cc1Oc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the RefChem:357196 page
Murcko scaffold O=c1[nH]c(=S)[nH]cc1Oc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 5 of 5 chemicals

5-(4-Chlorophenoxy)-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C10H7ClN2O2S, CAS 42310-30-5
5-(4-Chlorophenoxy)-2-sulfanylidene-1H-pyrimidin-4-one
CAS 42310-30-5C10H7ClN2O2S
RefChem:357196 chemical structure, C10H8N2O2S, CAS 52295-87-1
RefChem:357196
CAS 52295-87-1C10H8N2O2S
RefChem:357076 chemical structure, C10H6Cl2N2O2S, CAS 7144-25-4
RefChem:357076
CAS 7144-25-4C10H6Cl2N2O2S
2-Thioxo-5-(m-tolyloxy)-2,3-dihydropyrimidin-4(1H)-one chemical structure, C11H10N2O2S, CAS 66047-03-8
2-Thioxo-5-(m-tolyloxy)-2,3-dihydropyrimidin-4(1H)-one
CAS 66047-03-8C11H10N2O2S
2-Mercapto-5-(4-methoxyphenoxy)pyrimidine-4,6-diol chemical structure, C11H10N2O4S, CAS 1245644-64-7
2-Mercapto-5-(4-methoxyphenoxy)pyrimidine-4,6-diol
CAS 1245644-64-7C11H10N2O4S