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Murcko scaffold

Ring system with 4 rings and 25 atoms

10 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
10
With full pages
7
Scaffold SMILES

O=C(C1=CC(=O)N(CC2CCCO2)C1c1ccccc1)c1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(CC2CCCO2)C1c1ccccc1)c1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

5-(3-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one chemical structure, C20H18ClNO5, CAS 618072-37-0
5-(3-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one
CAS 618072-37-0C20H18ClNO5
2-(4-Butoxyphenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(oxolan-2-ylmethyl)-2H-pyrrol-5-one chemical structure, C25H29NO6, CAS 608493-64-7
2-(4-Butoxyphenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(oxolan-2-ylmethyl)-2H-pyrrol-5-one
CAS 608493-64-7C25H29NO6
5-(3,4-Dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one chemical structure, C22H23NO7, CAS 618072-42-7
5-(3,4-Dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one
CAS 618072-42-7C22H23NO7
5-(3-Bromophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one chemical structure, C20H18BrNO5, CAS 618072-36-9
5-(3-Bromophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one
CAS 618072-36-9C20H18BrNO5
Methyl 4-[3-(furan-2-ylcarbonyl)-4-hydroxy-5-oxo-1-(tetrahydrofuran-2-ylmethyl)-2,5-dihydro-1H-pyrrol-2-yl]benzoate chemical structure, C22H21NO7, CAS 618072-40-5
Methyl 4-[3-(furan-2-ylcarbonyl)-4-hydroxy-5-oxo-1-(tetrahydrofuran-2-ylmethyl)-2,5-dihydro-1H-pyrrol-2-yl]benzoate
CAS 618072-40-5C22H21NO7
5-(2-Fluorophenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one chemical structure, C21H20FNO5, CAS 618073-42-0
5-(2-Fluorophenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one
CAS 618073-42-0C21H20FNO5
5-(4-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one chemical structure, C20H18ClNO5, CAS 618072-38-1
5-(4-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one
CAS 618072-38-1C20H18ClNO5
3-(Furan-2-carbonyl)-4-hydroxy-2-(4-hydroxyphenyl)-1-(oxolan-2-ylmethyl)-2H-pyrrol-5-one chemical structure, C20H19NO6, CAS 5173-40-0
3-(Furan-2-carbonyl)-4-hydroxy-2-(4-hydroxyphenyl)-1-(oxolan-2-ylmethyl)-2H-pyrrol-5-one
CAS 5173-40-0C20H19NO6
2-(3,4-Dimethoxyphenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(oxolan-2-ylmethyl)-2H-pyrrol-5-one chemical structure, C23H25NO7, CAS 618376-47-9
2-(3,4-Dimethoxyphenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(oxolan-2-ylmethyl)-2H-pyrrol-5-one
CAS 618376-47-9C23H25NO7
2-(3-Chlorophenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(oxolan-2-ylmethyl)-2H-pyrrol-5-one chemical structure, C21H20ClNO5, CAS 618373-88-9
2-(3-Chlorophenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(oxolan-2-ylmethyl)-2H-pyrrol-5-one
CAS 618373-88-9C21H20ClNO5