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Murcko scaffold

Ring system with 4 rings and 23 atoms

15 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
15
With full pages
4
Scaffold SMILES

O=c1c(-c2ccccc2)coc2c(CN3CCCC3)cccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(-c2ccccc2)coc2c(CN3CCCC3)cccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

RefChem:345393 chemical structure, C22H20F3NO4, CAS 6143-22-2
RefChem:345393
CAS 6143-22-2C22H20F3NO4
7-Hydroxy-3-phenyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C20H19NO3, CAS 448238-32-2
7-Hydroxy-3-phenyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one
CAS 448238-32-2C20H19NO3
7-Hydroxy-2-methyl-3-phenyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C21H21NO3, CAS 844652-94-4
7-Hydroxy-2-methyl-3-phenyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one
CAS 844652-94-4C21H21NO3
3-(4-Bromophenyl)-7-hydroxy-2-methyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C21H20BrNO3, CAS 846063-00-1
3-(4-Bromophenyl)-7-hydroxy-2-methyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one
CAS 846063-00-1C21H20BrNO3
3-(4-Chlorophenyl)-7-hydroxy-2-methyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C21H20ClNO3, CAS 848753-89-9
3-(4-Chlorophenyl)-7-hydroxy-2-methyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one
CAS 848753-89-9C21H20ClNO3
3-(3,4-Dimethoxyphenyl)-7-hydroxy-8-(1-pyrrolidinylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C23H22F3NO5, CAS 307535-01-9
3-(3,4-Dimethoxyphenyl)-7-hydroxy-8-(1-pyrrolidinylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 307535-01-9C23H22F3NO5
3-(4-Chlorophenyl)-7-hydroxy-8-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C21H17ClF3NO3, CAS 442651-55-0
3-(4-Chlorophenyl)-7-hydroxy-8-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 442651-55-0C21H17ClF3NO3
7-Hydroxy-3-phenyl-8-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C21H18F3NO3, CAS 384802-95-3
7-Hydroxy-3-phenyl-8-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 384802-95-3C21H18F3NO3
3-(3,4-Dimethoxyphenyl)-7-hydroxy-2-methyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C23H25NO5, CAS 637753-17-4
3-(3,4-Dimethoxyphenyl)-7-hydroxy-2-methyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one
CAS 637753-17-4C23H25NO5
7-Hydroxy-3-(4-methoxyphenyl)-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C21H21NO4, CAS 637753-18-5
7-Hydroxy-3-(4-methoxyphenyl)-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one
CAS 637753-18-5C21H21NO4
3-(3,4-Dimethoxyphenyl)-7-hydroxy-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C22H23NO5, CAS 637753-19-6
3-(3,4-Dimethoxyphenyl)-7-hydroxy-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one
CAS 637753-19-6C22H23NO5
7-Hydroxy-3-(2-methoxyphenyl)-2-methyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C22H23NO4, CAS 637753-62-9
7-Hydroxy-3-(2-methoxyphenyl)-2-methyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one
CAS 637753-62-9C22H23NO4
7-Hydroxy-3-(4-methoxyphenyl)-2-methyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C22H23NO4, CAS 637753-16-3
7-Hydroxy-3-(4-methoxyphenyl)-2-methyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one
CAS 637753-16-3C22H23NO4
7-Hydroxy-3-(4-methoxyphenyl)-8-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C22H20F3NO4, CAS 637753-66-3
7-Hydroxy-3-(4-methoxyphenyl)-8-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 637753-66-3C22H20F3NO4
((3-(4-Fluorophenyl)-7-hydroxy-2-methyl-4-oxo-4H-chromen-8-yl)methyl)-D-proline chemical structure, C22H20FNO5, CAS 1574554-76-9
((3-(4-Fluorophenyl)-7-hydroxy-2-methyl-4-oxo-4H-chromen-8-yl)methyl)-D-proline
CAS 1574554-76-9C22H20FNO5