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Murcko scaffold

1-(3-Pyrrolidin-1-ylphenyl)piperazine scaffold

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
12
With full pages
3
Scaffold SMILES

c1cc(N2CCCC2)cc(N2CCNCC2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(3-Pyrrolidin-1-ylphenyl)piperazine page
Murcko scaffold c1cc(N2CCCC2)cc(N2CCNCC2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

1-(4-Nitro-3-pyrrolidin-1-ylphenyl)piperazine chemical structure, C14H20N4O2, CAS 330633-83-5
1-(4-Nitro-3-pyrrolidin-1-ylphenyl)piperazine
CAS 330633-83-5C14H20N4O2
1-Methylsulfonyl-4-(4-nitro-3-pyrrolidin-1-ylphenyl)piperazine chemical structure, C15H22N4O4S, CAS 346704-10-7
1-Methylsulfonyl-4-(4-nitro-3-pyrrolidin-1-ylphenyl)piperazine
CAS 346704-10-7C15H22N4O4S
1-[4-Fluoro-2-nitro-5-(1-pyrrolidinyl)phenyl]-4-propionylpiperazine chemical structure, C17H23FN4O3, CAS 5934-64-5
1-[4-Fluoro-2-nitro-5-(1-pyrrolidinyl)phenyl]-4-propionylpiperazine
CAS 5934-64-5C17H23FN4O3
2,2-Dimethyl-1-[4-(4-nitro-3-pyrrolidin-1-ylphenyl)piperazin-1-yl]propan-1-one chemical structure, C19H28N4O3, CAS 662164-20-7
2,2-Dimethyl-1-[4-(4-nitro-3-pyrrolidin-1-ylphenyl)piperazin-1-yl]propan-1-one
CAS 662164-20-7C19H28N4O3
1-Ethylsulfonyl-4-(4-nitro-3-pyrrolidin-1-ylphenyl)piperazine chemical structure, C16H24N4O4S, CAS 662163-69-1
1-Ethylsulfonyl-4-(4-nitro-3-pyrrolidin-1-ylphenyl)piperazine
CAS 662163-69-1C16H24N4O4S
1-Methyl-4-(2-nitro-5-pyrrolidin-1-ylphenyl)piperazine chemical structure, C15H22N4O2, CAS 339297-28-8
1-Methyl-4-(2-nitro-5-pyrrolidin-1-ylphenyl)piperazine
CAS 339297-28-8C15H22N4O2
1-[4-Nitro-3-(1-pyrrolidinyl)phenyl]piperazine hydrochloride chemical structure, C14H21ClN4O2, CAS 1052148-98-7
1-[4-Nitro-3-(1-pyrrolidinyl)phenyl]piperazine hydrochloride
CAS 1052148-98-7C14H21ClN4O2
2-(Piperazin-1-yl)-4-(pyrrolidin-1-yl)aniline chemical structure, C14H22N4, CAS 111641-21-5
2-(Piperazin-1-yl)-4-(pyrrolidin-1-yl)aniline
CAS 111641-21-5C14H22N4
1-(3-Pyrrolidin-1-ylphenyl)piperazine chemical structure, C14H21N3, CAS 1368505-15-0
1-(3-Pyrrolidin-1-ylphenyl)piperazine
CAS 1368505-15-0C14H21N3
(S)-1-(3-(3-Fluoropyrrolidin-1-yl)-4-nitrophenyl)-4-methylpiperazine chemical structure, C15H21FN4O2, CAS 2247844-73-9
(S)-1-(3-(3-Fluoropyrrolidin-1-yl)-4-nitrophenyl)-4-methylpiperazine
CAS 2247844-73-9C15H21FN4O2
(S)-1-(3-(3-(Fluoromethyl)pyrrolidin-1-yl)-4-nitrophenyl)-4-methylpiperazine chemical structure, C16H23FN4O2, CAS 2287347-77-5
(S)-1-(3-(3-(Fluoromethyl)pyrrolidin-1-yl)-4-nitrophenyl)-4-methylpiperazine
CAS 2287347-77-5C16H23FN4O2
(S)-1-(3-(4-Methylpiperazin-1-yl)-4-nitrophenyl)pyrrolidin-3-ol chemical structure, C15H22N4O3, CAS 2411591-70-1
(S)-1-(3-(4-Methylpiperazin-1-yl)-4-nitrophenyl)pyrrolidin-3-ol
CAS 2411591-70-1C15H22N4O3