Murcko scaffold
Ring system with 4 rings and 28 atoms
27 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 28
- Chemicals
- 27
- With full pages
- 5
Scaffold SMILES
O=C(CSc1nc(=O)n(Cc2cccnc2)c2c1CCC2)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 27 of 27 chemicals
![N-(2-Methylphenyl)-2-[[2-oxo-1-(pyridin-3-ylmethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide chemical structure, C22H22N4O2S, CAS 946325-95-7](/s/PYVNPYAFBMTXQS-UHFFFAOYSA-N.svg)
N-(2-Methylphenyl)-2-[[2-oxo-1-(pyridin-3-ylmethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide
CAS 946325-95-7C22H22N4O2S
![N-(2,3-Dimethylphenyl)-2-[[2-oxo-1-(pyridin-3-ylmethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide chemical structure, C23H24N4O2S, CAS 946271-28-9](/s/MIGDVTZLZPZSMP-UHFFFAOYSA-N.svg)
N-(2,3-Dimethylphenyl)-2-[[2-oxo-1-(pyridin-3-ylmethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide
CAS 946271-28-9C23H24N4O2S
![N-(4-Isopropylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C24H26N4O2S, CAS 946271-01-8](/s/RLPWWSIIQDWYJG-UHFFFAOYSA-N.svg)
N-(4-Isopropylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 946271-01-8C24H26N4O2S
![N-(2-Methoxy-5-methylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C23H24N4O3S, CAS 946373-51-9](/s/ZIBOBBGHFVGMDC-UHFFFAOYSA-N.svg)
N-(2-Methoxy-5-methylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 946373-51-9C23H24N4O3S
![N-(3-Chloro-2-methylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C22H21ClN4O2S, CAS 946373-54-2](/s/BNQDKHWBAHQILY-UHFFFAOYSA-N.svg)
N-(3-Chloro-2-methylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 946373-54-2C22H21ClN4O2S
![N-(3-Fluoro-4-methylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C22H21FN4O2S, CAS 933204-28-5](/s/MYVIMFDNAIFWNN-UHFFFAOYSA-N.svg)
N-(3-Fluoro-4-methylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 933204-28-5C22H21FN4O2S
![2-((2-Oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(m-tolyl)acetamide chemical structure, C22H22N4O2S, CAS 946325-98-0](/s/OALKALQXTPECPZ-UHFFFAOYSA-N.svg)
2-((2-Oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(m-tolyl)acetamide
CAS 946325-98-0C22H22N4O2S
![N-Mesityl-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C24H26N4O2S, CAS 946271-39-2](/s/NAGJXELCPYDXAO-UHFFFAOYSA-N.svg)
N-Mesityl-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 946271-39-2C24H26N4O2S
![N-(3-Methoxyphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C22H22N4O3S, CAS 946219-84-7](/s/KZHSXNSGTWHUNN-UHFFFAOYSA-N.svg)
N-(3-Methoxyphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 946219-84-7C22H22N4O3S
![N-(3-Chlorophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C21H19ClN4O2S, CAS 946271-71-2](/s/VTLVBTWMYMLOMN-UHFFFAOYSA-N.svg)
N-(3-Chlorophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 946271-71-2C21H19ClN4O2S
![N-(2,4-Difluorophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C21H18F2N4O2S, CAS 933251-39-9](/s/XZPUOQQWTQGOAB-UHFFFAOYSA-N.svg)
N-(2,4-Difluorophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 933251-39-9C21H18F2N4O2S
![N-(3-Acetylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C23H22N4O3S, CAS 933205-07-3](/s/YBKIWSLFQYIHDT-UHFFFAOYSA-N.svg)
N-(3-Acetylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 933205-07-3C23H22N4O3S
![N-(4-Butylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C25H28N4O2S, CAS 899746-93-1](/s/LAIMDUXRSSTIGX-UHFFFAOYSA-N.svg)
N-(4-Butylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 899746-93-1C25H28N4O2S
![N-(4-Ethoxyphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C23H24N4O3S, CAS 899987-01-0](/s/WKKZRCDFJMUWMQ-UHFFFAOYSA-N.svg)
N-(4-Ethoxyphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 899987-01-0C23H24N4O3S
![N-(3-Acetamidophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C23H23N5O3S, CAS 899955-13-6](/s/VBFCHCAZDBSUMI-UHFFFAOYSA-N.svg)
N-(3-Acetamidophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 899955-13-6C23H23N5O3S
![N-(4-Acetamidophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C23H23N5O3S, CAS 899987-15-6](/s/OAWXHAHMNGVTRL-UHFFFAOYSA-N.svg)
N-(4-Acetamidophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 899987-15-6C23H23N5O3S
![N-(3,4-Difluorophenyl)-2-({2-oxo-1-[(pyridin-3-yl)methyl]-1H,2H,5H,6H,7H-cyclopenta[d]pyrimidin-4-yl}sulfanyl)acetamide chemical structure, C21H18F2N4O2S, CAS 946219-33-6](/s/WRTGPJADVVEJJJ-UHFFFAOYSA-N.svg)
N-(3,4-Difluorophenyl)-2-({2-oxo-1-[(pyridin-3-yl)methyl]-1H,2H,5H,6H,7H-cyclopenta[d]pyrimidin-4-yl}sulfanyl)acetamide
CAS 946219-33-6C21H18F2N4O2S
![N-(2-Nitrophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C21H19N5O4S, CAS 933231-23-3](/s/SGLQRVZFMFQWAR-UHFFFAOYSA-N.svg)
N-(2-Nitrophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 933231-23-3C21H19N5O4S
![N-(4-Chlorophenyl)-2-({2-oxo-1-[(pyridin-3-yl)methyl]-1H,2H,5H,6H,7H-cyclopenta[d]pyrimidin-4-yl}sulfanyl)acetamide chemical structure, C21H19ClN4O2S, CAS 946374-24-9](/s/UVRXQEBTABTRQR-UHFFFAOYSA-N.svg)
N-(4-Chlorophenyl)-2-({2-oxo-1-[(pyridin-3-yl)methyl]-1H,2H,5H,6H,7H-cyclopenta[d]pyrimidin-4-yl}sulfanyl)acetamide
CAS 946374-24-9C21H19ClN4O2S
![N-(4-Acetylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C23H22N4O3S, CAS 946271-83-6](/s/MLDALHYCSSNFIC-UHFFFAOYSA-N.svg)
N-(4-Acetylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 946271-83-6C23H22N4O3S
![N-(3-Nitrophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C21H19N5O4S, CAS 933251-51-5](/s/CXXUHIZNVCZMJW-UHFFFAOYSA-N.svg)
N-(3-Nitrophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 933251-51-5C21H19N5O4S
![N-(2-Methoxyphenyl)-2-({2-oxo-1-[(pyridin-3-yl)methyl]-1H,2H,5H,6H,7H-cyclopenta[d]pyrimidin-4-yl}sulfanyl)acetamide chemical structure, C22H22N4O3S, CAS 932961-78-9](/s/KMTDPTVXZHSCKV-UHFFFAOYSA-N.svg)
N-(2-Methoxyphenyl)-2-({2-oxo-1-[(pyridin-3-yl)methyl]-1H,2H,5H,6H,7H-cyclopenta[d]pyrimidin-4-yl}sulfanyl)acetamide
CAS 932961-78-9C22H22N4O3S
![2-((2-Oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(p-tolyl)acetamide chemical structure, C22H22N4O2S, CAS 932961-75-6](/s/KPOHHSHPSVQUCR-UHFFFAOYSA-N.svg)
2-((2-Oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(p-tolyl)acetamide
CAS 932961-75-6C22H22N4O2S
![N-(3,5-Dimethylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C23H24N4O2S, CAS 946271-31-4](/s/NYXNHOVUCUIZNH-UHFFFAOYSA-N.svg)
N-(3,5-Dimethylphenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 946271-31-4C23H24N4O2S
- N-(2-Fluorophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide946374-12-5C21H19FN4O2S
- N-(4-Fluorophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide932961-87-0C21H19FN4O2S
- N-(4-Nitrophenyl)-2-((2-oxo-1-(pyridin-3-ylmethyl)-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide933251-47-9C21H19N5O4S
Related scaffolds
Same ring framework with different atoms or bond orders
