CompoundList
Sign in
Murcko scaffold

3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione scaffold

29 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
29
Chemicals
29
With full pages
10
Scaffold SMILES

O=C1CC(N2CCN(Cc3ccc4c(c3)OCO4)CC2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione page
Murcko scaffold O=C1CC(N2CCN(Cc3ccc4c(c3)OCO4)CC2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione chemical structure, C22H23N3O4, CAS 299949-36-3
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione
CAS 299949-36-3C22H23N3O4
4-{3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2,5-dioxopyrrolidin-1-yl}benzoic acid chemical structure, C23H23N3O6, CAS 296800-80-1
4-{3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2,5-dioxopyrrolidin-1-yl}benzoic acid
CAS 296800-80-1C23H23N3O6
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-ethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C24H27N3O5, CAS 299949-41-0
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-ethoxyphenyl)pyrrolidine-2,5-dione
CAS 299949-41-0C24H27N3O5
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-chlorophenyl)pyrrolidine-2,5-dione chemical structure, C22H22ClN3O4, CAS 296800-81-2
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-chlorophenyl)pyrrolidine-2,5-dione
CAS 296800-81-2C22H22ClN3O4
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(2-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C23H25N3O5, CAS 299949-50-1
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(2-methoxyphenyl)pyrrolidine-2,5-dione
CAS 299949-50-1C23H25N3O5
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-chlorophenyl)pyrrolidine-2,5-dione chemical structure, C22H22ClN3O4, CAS 299949-54-5
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-chlorophenyl)pyrrolidine-2,5-dione
CAS 299949-54-5C22H22ClN3O4
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C23H25N3O5, CAS 299949-55-6
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione
CAS 299949-55-6C23H25N3O5
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-[4-(hexyloxy)phenyl]pyrrolidine-2,5-dione chemical structure, C28H35N3O5, CAS 331966-28-0
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-[4-(hexyloxy)phenyl]pyrrolidine-2,5-dione
CAS 331966-28-0C28H35N3O5
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(2,4-dimethylphenyl)pyrrolidine-2,5-dione chemical structure, C24H27N3O4, CAS 313377-72-9
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(2,4-dimethylphenyl)pyrrolidine-2,5-dione
CAS 313377-72-9C24H27N3O4
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione chemical structure, C22H21Cl2N3O4, CAS 333398-84-8
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione
CAS 333398-84-8C22H21Cl2N3O4
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-propoxyphenyl)pyrrolidine-2,5-dione chemical structure, C25H29N3O5, CAS 296769-63-6
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-propoxyphenyl)pyrrolidine-2,5-dione
CAS 296769-63-6C25H29N3O5
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C23H25N3O5, CAS 331966-29-1
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-methoxyphenyl)pyrrolidine-2,5-dione
CAS 331966-29-1C23H25N3O5
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3,4-dichlorophenyl)pyrrolidine-2,5-dione chemical structure, C22H21Cl2N3O4, CAS 331966-35-9
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3,4-dichlorophenyl)pyrrolidine-2,5-dione
CAS 331966-35-9C22H21Cl2N3O4
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-bromophenyl)pyrrolidine-2,5-dione chemical structure, C22H22BrN3O4, CAS 313705-28-1
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-bromophenyl)pyrrolidine-2,5-dione
CAS 313705-28-1C22H22BrN3O4
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-bromophenyl)pyrrolidine-2,5-dione chemical structure, C22H22BrN3O4, CAS 331760-02-2
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-bromophenyl)pyrrolidine-2,5-dione
CAS 331760-02-2C22H22BrN3O4
Methyl 4-[3-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C24H25N3O6, CAS 330865-50-4
Methyl 4-[3-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 330865-50-4C24H25N3O6
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-ethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C24H27N3O5, CAS 332052-89-8
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-ethoxyphenyl)pyrrolidine-2,5-dione
CAS 332052-89-8C24H27N3O5
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-butoxyphenyl)pyrrolidine-2,5-dione chemical structure, C26H31N3O5, CAS 312504-79-3
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-butoxyphenyl)pyrrolidine-2,5-dione
CAS 312504-79-3C26H31N3O5
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-methylphenyl)pyrrolidine-2,5-dione chemical structure, C23H25N3O4, CAS 5931-00-0
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-methylphenyl)pyrrolidine-2,5-dione
CAS 5931-00-0C23H25N3O4
Ethyl 4-[3-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C25H27N3O6, CAS 5933-66-4
Ethyl 4-[3-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 5933-66-4C25H27N3O6
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-iodophenyl)pyrrolidine-2,5-dione chemical structure, C22H22IN3O4, CAS 312281-51-9
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-iodophenyl)pyrrolidine-2,5-dione
CAS 312281-51-9C22H22IN3O4
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-chloro-4-methylphenyl)pyrrolidine-2,5-dione chemical structure, C23H24ClN3O4, CAS 351385-69-8
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(3-chloro-4-methylphenyl)pyrrolidine-2,5-dione
CAS 351385-69-8C23H24ClN3O4
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-ethylphenyl)pyrrolidine-2,5-dione chemical structure, C24H27N3O4, CAS 370870-76-1
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(4-ethylphenyl)pyrrolidine-2,5-dione
CAS 370870-76-1C24H27N3O4
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,5-dione chemical structure, C23H22F3N3O4, CAS 371140-91-9
3-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,5-dione
CAS 371140-91-9C23H22F3N3O4