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Murcko scaffold

Ring system with 3 rings and 19 atoms

180 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
180
With full pages
50
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(c1ccccc1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 180 chemicals

2-(Benzenesulfonyl)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C18H21NO4S, CAS 65492-83-3
2-(Benzenesulfonyl)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
CAS 65492-83-3C18H21NO4S
4-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)aniline chemical structure, C15H16N2O2S, CAS 7252-02-0
4-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)aniline
CAS 7252-02-0C15H16N2O2S
Isoquinoline, 1,2,3,4-tetrahydro-2-(p-tolylsulfonyl)- chemical structure, C16H17NO2S, CAS 20335-69-7
Isoquinoline, 1,2,3,4-tetrahydro-2-(p-tolylsulfonyl)-
CAS 20335-69-7C16H17NO2S
2-[(2,5-Dichlorophenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C15H13Cl2NO2S, CAS 329939-49-3
2-[(2,5-Dichlorophenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
CAS 329939-49-3C15H13Cl2NO2S
N-(2-(4-((3,4-Dihydro-2(1H)-isoquinolinyl)sulfonyl)phenyl)ethyl)acetamide chemical structure, C19H22N2O3S, CAS 352330-60-0
N-(2-(4-((3,4-Dihydro-2(1H)-isoquinolinyl)sulfonyl)phenyl)ethyl)acetamide
CAS 352330-60-0C19H22N2O3S
2-[(3,4-Dimethoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C17H19NO4S, CAS 185243-76-9
2-[(3,4-Dimethoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
CAS 185243-76-9C17H19NO4S
2-(4-tert-Butylbenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C19H23NO2S, CAS 309285-52-7
2-(4-tert-Butylbenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline
CAS 309285-52-7C19H23NO2S
(3S)-2-(4-Methoxybenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid chemical structure, C17H17NO5S, CAS 1212493-61-2
(3S)-2-(4-Methoxybenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
CAS 1212493-61-2C17H17NO5S
(3R)-1,2,3,4-Tetrahydro-2-[(4-methoxyphenyl)sulfonyl]-3-isoquinolinecarboxylic Acid chemical structure, C17H17NO5S, CAS 236403-32-0
(3R)-1,2,3,4-Tetrahydro-2-[(4-methoxyphenyl)sulfonyl]-3-isoquinolinecarboxylic Acid
CAS 236403-32-0C17H17NO5S
3-(3,4-Dihydro-1H-isoquinoline-2-sulfonyl)-benzoic acid chemical structure, C16H15NO4S, CAS 327092-81-9
3-(3,4-Dihydro-1H-isoquinoline-2-sulfonyl)-benzoic acid
CAS 327092-81-9C16H15NO4S
5-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)-2-methoxybenzoic acid chemical structure, C17H17NO5S, CAS 170287-75-9
5-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)-2-methoxybenzoic acid
CAS 170287-75-9C17H17NO5S
2-(2-Nitrophenyl)sulfonyl-3,4-dihydro-1H-isoquinoline chemical structure, C15H14N2O4S, CAS 321531-68-4
2-(2-Nitrophenyl)sulfonyl-3,4-dihydro-1H-isoquinoline
CAS 321531-68-4C15H14N2O4S
2-(4-Chlorophenyl)sulfonyl-3,4-dihydro-1H-isoquinoline chemical structure, C15H14ClNO2S, CAS 346691-52-9
2-(4-Chlorophenyl)sulfonyl-3,4-dihydro-1H-isoquinoline
CAS 346691-52-9C15H14ClNO2S
N-[4-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]acetamide chemical structure, C17H18N2O3S, CAS 303132-80-1
N-[4-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]acetamide
CAS 303132-80-1C17H18N2O3S
2-((4-Methoxy-2,5-dimethylphenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C18H21NO3S, CAS 667892-81-1
2-((4-Methoxy-2,5-dimethylphenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline
CAS 667892-81-1C18H21NO3S
2-(5-Methoxy-2,4-dimethyl-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline chemical structure, C18H21NO3S, CAS 694472-44-1
2-(5-Methoxy-2,4-dimethyl-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline
CAS 694472-44-1C18H21NO3S
2-(2-Methoxy-5-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline chemical structure, C17H19NO3S, CAS 765925-96-0
2-(2-Methoxy-5-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline
CAS 765925-96-0C17H19NO3S
2-[2-Methyl-5-(propan-2-yl)benzenesulfonyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C19H23NO2S, CAS 694484-10-1
2-[2-Methyl-5-(propan-2-yl)benzenesulfonyl]-1,2,3,4-tetrahydroisoquinoline
CAS 694484-10-1C19H23NO2S
2-((4-Ethoxyphenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C17H19NO3S, CAS 677293-99-1
2-((4-Ethoxyphenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline
CAS 677293-99-1C17H19NO3S
2-[(4-Fluorophenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C15H14FNO2S, CAS 313981-60-1
2-[(4-Fluorophenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
CAS 313981-60-1C15H14FNO2S
2-[(2,5-Dimethoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C17H19NO4S, CAS 496015-65-7
2-[(2,5-Dimethoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
CAS 496015-65-7C17H19NO4S
2-[(4-Nitrophenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C15H14N2O4S, CAS 64880-92-8
2-[(4-Nitrophenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
CAS 64880-92-8C15H14N2O4S
6,7-Dimethoxy-2-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline chemical structure, C18H21NO4S, CAS 14165-82-3
6,7-Dimethoxy-2-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline
CAS 14165-82-3C18H21NO4S
2-[(2,4,5-Trimethylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C18H21NO2S, CAS 496015-59-9
2-[(2,4,5-Trimethylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
CAS 496015-59-9C18H21NO2S