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Murcko scaffold

Ring system with 4 rings and 21 atoms

79 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
79
With full pages
7
Scaffold SMILES

c1ccc(-c2cn(-c3ccccc3)c3ncncc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cn(-c3ccccc3)c3ncncc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 79 chemicals

Cgp-62464 chemical structure, C18H14N4, CAS 121405-24-1
Cgp-62464
CAS 121405-24-1C18H14N4
5-(4-Methoxyphenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C19H16N4O, CAS 121405-30-9
5-(4-Methoxyphenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 121405-30-9C19H16N4O
N-(2-Methylpropyl)-5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C22H22N4, CAS 477225-83-5
N-(2-Methylpropyl)-5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 477225-83-5C22H22N4
N-(2,2-Dimethoxyethyl)-7-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C22H21FN4O2, CAS 477232-52-3
N-(2,2-Dimethoxyethyl)-7-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 477232-52-3C22H21FN4O2
7-(4-Methylphenyl)-N-(2-methylpropyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C23H24N4, CAS 477232-71-6
7-(4-Methylphenyl)-N-(2-methylpropyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 477232-71-6C23H24N4
N-(2,2-Dimethoxyethyl)-7-(4-methoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C23H24N4O3, CAS 477227-59-1
N-(2,2-Dimethoxyethyl)-7-(4-methoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 477227-59-1C23H24N4O3
4-Chloro-5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C18H12ClN3, CAS 287177-10-0
4-Chloro-5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS 287177-10-0C18H12ClN3
4-Chloro-7-(4-chlorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C18H11Cl2N3, CAS 507273-41-8
4-Chloro-7-(4-chlorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS 507273-41-8C18H11Cl2N3
4-Chloro-7-(4-methoxy-phenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C19H14ClN3O, CAS 220835-25-6
4-Chloro-7-(4-methoxy-phenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS 220835-25-6C19H14ClN3O
4-Chloro-7-(3-methylphenyl)-5-phenylpyrrolo[2,3-d]pyrimidine chemical structure, C19H14ClN3, CAS 890091-40-4
4-Chloro-7-(3-methylphenyl)-5-phenylpyrrolo[2,3-d]pyrimidine
CAS 890091-40-4C19H14ClN3
4-Chloro-7-(3-chloro-4-methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C19H13Cl2N3, CAS 887202-25-7
4-Chloro-7-(3-chloro-4-methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS 887202-25-7C19H13Cl2N3
4-Chloro-7-(3-chlorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C18H11Cl2N3, CAS 890091-44-8
4-Chloro-7-(3-chlorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS 890091-44-8C18H11Cl2N3
4-Chloro-7-(4-fluoro-phenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C18H11ClFN3, CAS 243665-99-8
4-Chloro-7-(4-fluoro-phenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS 243665-99-8C18H11ClFN3
7-(4-Bromophenyl)-4-chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C18H11BrClN3, CAS 220835-26-7
7-(4-Bromophenyl)-4-chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS 220835-26-7C18H11BrClN3
4-Chloro-5-phenyl-7-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C19H14ClN3, CAS 890091-48-2
4-Chloro-5-phenyl-7-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidine
CAS 890091-48-2C19H14ClN3
4-Chloro-7-(4-ethoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C20H16ClN3O, CAS 890091-50-6
4-Chloro-7-(4-ethoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS 890091-50-6C20H16ClN3O
4-Chloro-5-phenyl-7-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C19H11ClF3N3, CAS 887202-35-9
4-Chloro-5-phenyl-7-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine
CAS 887202-35-9C19H11ClF3N3
N-(3-Methoxypropyl)-7-(4-methylphenyl)-5-phenylpyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C23H24N4O, CAS 477232-73-8
N-(3-Methoxypropyl)-7-(4-methylphenyl)-5-phenylpyrrolo[2,3-d]pyrimidin-4-amine
CAS 477232-73-8C23H24N4O
7-(3-Chlorophenyl)-N-(2-methoxyethyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C21H19ClN4O, CAS 477230-72-1
7-(3-Chlorophenyl)-N-(2-methoxyethyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 477230-72-1C21H19ClN4O
Ethyl 2-[7-(3-fluorophenyl)-5-phenylpyrrolo[3,2-e]pyrimidin-4-ylthio]butanoate chemical structure, C24H22FN3O2S, CAS 442878-86-6
Ethyl 2-[7-(3-fluorophenyl)-5-phenylpyrrolo[3,2-e]pyrimidin-4-ylthio]butanoate
CAS 442878-86-6C24H22FN3O2S
2-(2-((5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethoxy)ethanol chemical structure, C22H22N4O2, CAS 477225-93-7
2-(2-((5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethoxy)ethanol
CAS 477225-93-7C22H22N4O2
N'-[7-(4-Bromophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-N,N-dimethylpropane-1,3-diamine chemical structure, C23H24BrN5, CAS 477231-40-6
N'-[7-(4-Bromophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-N,N-dimethylpropane-1,3-diamine
CAS 477231-40-6C23H24BrN5
2-(2-{[7-(4-Ethoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}ethoxy)ethanol chemical structure, C24H26N4O3, CAS 477233-94-6
2-(2-{[7-(4-Ethoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}ethoxy)ethanol
CAS 477233-94-6C24H26N4O3
2-(2-{[7-(4-Methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}ethoxy)ethanol chemical structure, C23H24N4O2, CAS 477232-81-8
2-(2-{[7-(4-Methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}ethoxy)ethanol
CAS 477232-81-8C23H24N4O2