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Murcko scaffold

Ring system with 5 rings and 16 atoms

38 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 16
Chemicals: 38
With full pages: 8

Scaffold SMILES

c1ccc(C2N3CC4CC(C3)CN2C4)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(C2N3CC4CC(C3)CN2C4)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

4-(5,7-Dimethyl-1,3-diaza-tricyclo[3.3.1.1*3,7*]dec-2-yl)-2-methoxy-phenol chemical structure, C17H24N2O2, CAS 697230-43-6

4-(5,7-Dimethyl-1,3-diaza-tricyclo[3.3.1.1*3,7*]dec-2-yl)-2-methoxy-phenol

CAS 697230-43-6C₁₇H₂₄N₂O₂

2-(3,4-Dimethoxy-phenyl)-5,7-dimethyl-1,3-diaza-tricyclo[3.3.1.1*3,7*]decane chemical structure, C18H26N2O2, CAS 697230-44-7

2-(3,4-Dimethoxy-phenyl)-5,7-dimethyl-1,3-diaza-tricyclo[3.3.1.1*3,7*]decane

CAS 697230-44-7C₁₈H₂₆N₂O₂

2-(4-Bromophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane chemical structure, C16H21BrN2, CAS 697230-40-3

2-(4-Bromophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane

CAS 697230-40-3C₁₆H₂₁BrN₂

2-(4-Fluorophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decan-6-ol chemical structure, C16H21FN2O, CAS 432017-13-5

2-(4-Fluorophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decan-6-ol

CAS 432017-13-5C₁₆H₂₁FN₂O

2-(4-Isopropylphenyl)-5,7-dimethyl-1,3-diazaadamantan-6-ol chemical structure, C19H28N2O, CAS 633286-35-8

2-(4-Isopropylphenyl)-5,7-dimethyl-1,3-diazaadamantan-6-ol

CAS 633286-35-8C₁₉H₂₈N₂O

5,7-Dimethyl-2-(3-nitrophenyl)-1,3-diazaadamantan-6-ol chemical structure, C16H21N3O3, CAS 332392-62-8

5,7-Dimethyl-2-(3-nitrophenyl)-1,3-diazaadamantan-6-ol

CAS 332392-62-8C₁₆H₂₁N₃O₃

2-(2-Fluorophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decan-6-ol chemical structure, C16H21FN2O, CAS 448911-32-8

2-(2-Fluorophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decan-6-ol

CAS 448911-32-8C₁₆H₂₁FN₂O

2-(5,7-Dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]dec-2-yl)-6-methoxyphenol chemical structure, C17H24N2O2, CAS 301353-30-0

2-(5,7-Dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]dec-2-yl)-6-methoxyphenol

CAS 301353-30-0C₁₇H₂₄N₂O₂

4-Bromo-2-(5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]dec-2-yl)phenol chemical structure, C16H21BrN2O, CAS 301353-32-2

4-Bromo-2-(5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]dec-2-yl)phenol

CAS 301353-32-2C₁₆H₂₁BrN₂O

2-(4-Isopropoxyphenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decan-6-ol chemical structure, C19H28N2O2, CAS 431937-59-6

2-(4-Isopropoxyphenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decan-6-ol

CAS 431937-59-6C₁₉H₂₈N₂O₂

2-(4-Methoxyphenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane chemical structure, C17H24N2O, CAS 302778-26-3

2-(4-Methoxyphenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane

CAS 302778-26-3C₁₇H₂₄N₂O

5,7-Dimethyl-2-phenyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane chemical structure, C16H22N2, CAS 302780-23-0

5,7-Dimethyl-2-phenyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane

CAS 302780-23-0C₁₆H₂₂N₂

2-(3-Bromophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane chemical structure, C16H21BrN2, CAS 305806-91-1

2-(3-Bromophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane

CAS 305806-91-1C₁₆H₂₁BrN₂

2-[4-(Dimethylamino)phenyl]-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decan-6-ol chemical structure, C18H27N3O, CAS 397880-03-4

2-[4-(Dimethylamino)phenyl]-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decan-6-ol

CAS 397880-03-4C₁₈H₂₇N₃O

5,7-Dimethyl-2-(4-nitrophenyl)-1,3-diazatricyclo[3.3.1.1~3,7~]decane chemical structure, C16H21N3O2, CAS 302903-67-9

5,7-Dimethyl-2-(4-nitrophenyl)-1,3-diazatricyclo[3.3.1.1~3,7~]decane

CAS 302903-67-9C₁₆H₂₁N₃O₂

5,7-Dimethyl-2-(2-nitrophenyl)-1,3-diazaadamantane chemical structure, C16H21N3O2, CAS 371227-33-7

5,7-Dimethyl-2-(2-nitrophenyl)-1,3-diazaadamantane

CAS 371227-33-7C₁₆H₂₁N₃O₂

4-(5,7-Dimethyl-1,3-diazaadamantan-2-yl)phenol chemical structure, C16H22N2O, CAS 307944-74-7

4-(5,7-Dimethyl-1,3-diazaadamantan-2-yl)phenol

CAS 307944-74-7C₁₆H₂₂N₂O

2-(4-Chlorophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane chemical structure, C16H21ClN2, CAS 303012-29-5

2-(4-Chlorophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane

CAS 303012-29-5C₁₆H₂₁ClN₂

5,7-Diisopropyl-2-phenyl-1,3-diazaadamantan-6-ol chemical structure, C20H30N2O, CAS 431984-64-4

5,7-Diisopropyl-2-phenyl-1,3-diazaadamantan-6-ol

CAS 431984-64-4C₂₀H₃₀N₂O

4-(5,7-Dimethyl-1,3-diazaadamantan-2-yl)benzene-1,2-diol chemical structure, C16H22N2O2, CAS 697230-42-5

4-(5,7-Dimethyl-1,3-diazaadamantan-2-yl)benzene-1,2-diol

CAS 697230-42-5C₁₆H₂₂N₂O₂

2-(4-Isopropoxyphenyl)-5,7-dimethyl-1,3-diazaadamantane chemical structure, C19H28N2O, CAS 697230-41-4

2-(4-Isopropoxyphenyl)-5,7-dimethyl-1,3-diazaadamantane

CAS 697230-41-4C₁₉H₂₈N₂O

2-(2-Fluorophenyl)-5,7-dimethyl-1,3-diazaadamantane chemical structure, C16H21FN2, CAS 303039-36-3

2-(2-Fluorophenyl)-5,7-dimethyl-1,3-diazaadamantane

CAS 303039-36-3C₁₆H₂₁FN₂

2-(4-Ethylphenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane chemical structure, C18H26N2, CAS 697230-39-0

2-(4-Ethylphenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane

CAS 697230-39-0C₁₈H₂₆N₂

2-(4-Fluorophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane chemical structure, C16H21FN2, CAS 585552-42-7

2-(4-Fluorophenyl)-5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]decane

CAS 585552-42-7C₁₆H₂₁FN₂