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Murcko scaffold

2-[2-(1H-Indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione scaffold

30 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
30
With full pages
5
Scaffold SMILES

O=C1c2ccccc2C(=O)N1CCc1c[nH]c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-[2-(1H-Indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione page
Murcko scaffold O=C1c2ccccc2C(=O)N1CCc1c[nH]c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

2-[2-(1H-Indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C18H14N2O2, CAS 15741-71-6
2-[2-(1H-Indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione
CAS 15741-71-6C18H14N2O2
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid chemical structure, C19H14N2O4, CAS 32675-71-1
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
CAS 32675-71-1C19H14N2O4
2-[1-(1H-Indol-3-yl)propan-2-yl]isoindole-1,3-dione chemical structure, C19H16N2O2, CAS 65020-17-9
2-[1-(1H-Indol-3-yl)propan-2-yl]isoindole-1,3-dione
CAS 65020-17-9C19H16N2O2
2-[2-(1H-Indol-3-yl)ethyl]-4-nitroisoindole-1,3-dione chemical structure, C18H13N3O4, CAS 293324-73-9
2-[2-(1H-Indol-3-yl)ethyl]-4-nitroisoindole-1,3-dione
CAS 293324-73-9C18H13N3O4
2-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)isoindole-1,3-dione chemical structure, C18H14N2O3, CAS 53157-46-3
2-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)isoindole-1,3-dione
CAS 53157-46-3C18H14N2O3
2-(2-(5-Methoxy-1H-indol-3-yl)ethyl)isoindoline-1,3-dione chemical structure, C19H16N2O3, CAS 55747-66-5
2-(2-(5-Methoxy-1H-indol-3-yl)ethyl)isoindoline-1,3-dione
CAS 55747-66-5C19H16N2O3
2-[2-(1H-Indol-3-yl)ethyl]-1,3-dioxoisoindoline-5-carboxylic acid chemical structure, C19H14N2O4, CAS 296266-01-8
2-[2-(1H-Indol-3-yl)ethyl]-1,3-dioxoisoindoline-5-carboxylic acid
CAS 296266-01-8C19H14N2O4
Ethyl 3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-5,7-dimethoxy-1H-indole-2-carboxylate chemical structure, C23H22N2O6, CAS 94850-21-2
Ethyl 3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-5,7-dimethoxy-1H-indole-2-carboxylate
CAS 94850-21-2C23H22N2O6
2-[2-(7-Methoxy-5-nitro-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C19H15N3O5, CAS 94830-05-4
2-[2-(7-Methoxy-5-nitro-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione
CAS 94830-05-4C19H15N3O5
2-[2-(7-Methoxy-4-nitro-1H-indol-3-yl)ethyl]isoindole-1,3-dione chemical structure, C19H15N3O5, CAS 94830-03-2
2-[2-(7-Methoxy-4-nitro-1H-indol-3-yl)ethyl]isoindole-1,3-dione
CAS 94830-03-2C19H15N3O5
Ethyl 3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-5-methoxy-1H-indole-2-carboxylate chemical structure, C22H20N2O5, CAS 55747-53-0
Ethyl 3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-5-methoxy-1H-indole-2-carboxylate
CAS 55747-53-0C22H20N2O5
2-[2-(5-Methoxy-7-nitro-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C19H15N3O5, CAS 94830-04-3
2-[2-(5-Methoxy-7-nitro-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione
CAS 94830-04-3C19H15N3O5
Ethyl 3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-5-iodo-1H-indole-2-carboxylate chemical structure, C21H17IN2O4, CAS 282103-13-3
Ethyl 3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-5-iodo-1H-indole-2-carboxylate
CAS 282103-13-3C21H17IN2O4
Ethyl 3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-5-methyl-1H-indole-2-carboxylate chemical structure, C22H20N2O4, CAS 55747-54-1
Ethyl 3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-5-methyl-1H-indole-2-carboxylate
CAS 55747-54-1C22H20N2O4
Serotonin impurity 11 chemical structure, C20H16N2O5, CAS 55747-60-9
Serotonin impurity 11
CAS 55747-60-9C20H16N2O5
Ethyl 3-[2-(1,3-dioxoisoindol-2-yl)ethyl]-7-methyl-1H-indole-2-carboxylate chemical structure, C22H20N2O4, CAS 354146-91-1
Ethyl 3-[2-(1,3-dioxoisoindol-2-yl)ethyl]-7-methyl-1H-indole-2-carboxylate
CAS 354146-91-1C22H20N2O4
2-[2-(2-Bromo-1H-indol-3-yl)-ethyl]-isoindole-1,3-dione chemical structure, C18H13BrN2O2, CAS 192182-46-0
2-[2-(2-Bromo-1H-indol-3-yl)-ethyl]-isoindole-1,3-dione
CAS 192182-46-0C18H13BrN2O2
2-[2-(1-Methyl-1H-indol-3-yl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H16N2O2, CAS 70369-20-9
2-[2-(1-Methyl-1H-indol-3-yl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione
CAS 70369-20-9C19H16N2O2
2-[2-(5-Nitro-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C18H13N3O4, CAS 55747-70-1
2-[2-(5-Nitro-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione
CAS 55747-70-1C18H13N3O4
2-[2-(1H-Indol-3-yl)ethyl]-1,3-dioxo-N-[3-(propan-2-yloxy)propyl]-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C25H27N3O4, CAS 1081146-51-1
2-[2-(1H-Indol-3-yl)ethyl]-1,3-dioxo-N-[3-(propan-2-yloxy)propyl]-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 1081146-51-1C25H27N3O4
2-[2-(1H-Indol-3-yl)ethyl]-N-(2-methoxyethyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C22H21N3O4, CAS 1081131-14-7
2-[2-(1H-Indol-3-yl)ethyl]-N-(2-methoxyethyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 1081131-14-7C22H21N3O4
Methyl N-({2-[2-(1H-indol-3-yl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl}carbonyl)glycinate chemical structure, C22H19N3O5, CAS 1081128-83-7
Methyl N-({2-[2-(1H-indol-3-yl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl}carbonyl)glycinate
CAS 1081128-83-7C22H19N3O5
N-(5-Hydroxypentyl)-2-[2-(1H-indol-3-yl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C24H25N3O4, CAS 1081145-74-5
N-(5-Hydroxypentyl)-2-[2-(1H-indol-3-yl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 1081145-74-5C24H25N3O4
2-[2-(1H-Indol-3-yl)ethyl]-N-(3-methoxypropyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C23H23N3O4, CAS 1081144-23-1
2-[2-(1H-Indol-3-yl)ethyl]-N-(3-methoxypropyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 1081144-23-1C23H23N3O4