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Murcko scaffold

Ring system with 4 rings and 26 atoms

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
20
With full pages
2
Scaffold SMILES

N=c1c2ccccc2nc(SCc2ccccc2)n1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold N=c1c2ccccc2nc(SCc2ccccc2)n1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

2-[(2,5-Dimethylbenzyl)sulfanyl]-6,7-dimethoxy-3-(4-methoxybenzyl)-4(3H)-quinazolinimine chemical structure, C27H29N3O3S, CAS 439096-24-9
2-[(2,5-Dimethylbenzyl)sulfanyl]-6,7-dimethoxy-3-(4-methoxybenzyl)-4(3H)-quinazolinimine
CAS 439096-24-9C27H29N3O3S
2-(Benzylsulfanyl)-3-(3-chloro-4-methoxybenzyl)-6,7-dimethoxy-4(3H)-quinazolinimine chemical structure, C25H24ClN3O3S, CAS 477848-72-9
2-(Benzylsulfanyl)-3-(3-chloro-4-methoxybenzyl)-6,7-dimethoxy-4(3H)-quinazolinimine
CAS 477848-72-9C25H24ClN3O3S
6,7-Dimethoxy-3-(4-methoxybenzyl)-2-[(2-methylbenzyl)sulfanyl]-4(3H)-quinazolinimine chemical structure, C26H27N3O3S, CAS 477848-73-0
6,7-Dimethoxy-3-(4-methoxybenzyl)-2-[(2-methylbenzyl)sulfanyl]-4(3H)-quinazolinimine
CAS 477848-73-0C26H27N3O3S
3-[(2-Chlorophenyl)methyl]-6,7-dimethoxy-2-[(3-methoxyphenyl)methylsulfanyl]quinazolin-4-imine chemical structure, C25H24ClN3O3S, CAS 860610-63-5
3-[(2-Chlorophenyl)methyl]-6,7-dimethoxy-2-[(3-methoxyphenyl)methylsulfanyl]quinazolin-4-imine
CAS 860610-63-5C25H24ClN3O3S
3-(3-Chloro-4-methoxybenzyl)-6,7-dimethoxy-2-[(4-methylbenzyl)sulfanyl]-4(3H)-quinazolinimine chemical structure, C26H26ClN3O3S, CAS 439121-05-8
3-(3-Chloro-4-methoxybenzyl)-6,7-dimethoxy-2-[(4-methylbenzyl)sulfanyl]-4(3H)-quinazolinimine
CAS 439121-05-8C26H26ClN3O3S
3-(3-Chloro-4-methoxybenzyl)-6,7-dimethoxy-2-[(2-methylbenzyl)sulfanyl]-4(3H)-quinazolinimine chemical structure, C26H26ClN3O3S, CAS 478249-80-8
3-(3-Chloro-4-methoxybenzyl)-6,7-dimethoxy-2-[(2-methylbenzyl)sulfanyl]-4(3H)-quinazolinimine
CAS 478249-80-8C26H26ClN3O3S
2-{[4-(tert-Butyl)benzyl]sulfanyl}-6,7-dimethoxy-3-(4-methoxybenzyl)-4(3H)-quinazolinimine chemical structure, C29H33N3O3S, CAS 439096-26-1
2-{[4-(tert-Butyl)benzyl]sulfanyl}-6,7-dimethoxy-3-(4-methoxybenzyl)-4(3H)-quinazolinimine
CAS 439096-26-1C29H33N3O3S
3-(2-Chlorobenzyl)-2-[(2-fluorobenzyl)sulfanyl]-6,7-dimethoxy-4(3H)-quinazolinimine chemical structure, C24H21ClFN3O2S, CAS 860610-57-7
3-(2-Chlorobenzyl)-2-[(2-fluorobenzyl)sulfanyl]-6,7-dimethoxy-4(3H)-quinazolinimine
CAS 860610-57-7C24H21ClFN3O2S
3-(2-Chlorobenzyl)-6,7-dimethoxy-2-{[3-(trifluoromethyl)benzyl]sulfanyl}-4(3H)-quinazolinimine chemical structure, C25H21ClF3N3O2S, CAS 860610-62-4
3-(2-Chlorobenzyl)-6,7-dimethoxy-2-{[3-(trifluoromethyl)benzyl]sulfanyl}-4(3H)-quinazolinimine
CAS 860610-62-4C25H21ClF3N3O2S
3-(2-Chlorobenzyl)-2-[(mesitylmethyl)sulfanyl]-6,7-dimethoxy-4(3H)-quinazolinimine chemical structure, C27H28ClN3O2S, CAS 860610-65-7
3-(2-Chlorobenzyl)-2-[(mesitylmethyl)sulfanyl]-6,7-dimethoxy-4(3H)-quinazolinimine
CAS 860610-65-7C27H28ClN3O2S
2-[(4-Fluorobenzyl)sulfanyl]-6,7-dimethoxy-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine chemical structure, C25H21F4N3O2S, CAS 439093-89-7
2-[(4-Fluorobenzyl)sulfanyl]-6,7-dimethoxy-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine
CAS 439093-89-7C25H21F4N3O2S
2-[(2,5-Dimethylbenzyl)sulfanyl]-6,7-dimethoxy-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine chemical structure, C27H26F3N3O2S, CAS 691868-85-6
2-[(2,5-Dimethylbenzyl)sulfanyl]-6,7-dimethoxy-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine
CAS 691868-85-6C27H26F3N3O2S
2-[(4-Chlorobenzyl)sulfanyl]-6,7-dimethoxy-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine chemical structure, C25H21ClF3N3O2S, CAS 439093-92-2
2-[(4-Chlorobenzyl)sulfanyl]-6,7-dimethoxy-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine
CAS 439093-92-2C25H21ClF3N3O2S
6,7-Dimethoxy-2-[(3-methoxybenzyl)sulfanyl]-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine chemical structure, C26H24F3N3O3S, CAS 691868-92-5
6,7-Dimethoxy-2-[(3-methoxybenzyl)sulfanyl]-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine
CAS 691868-92-5C26H24F3N3O3S
6,7-Dimethoxy-2-[(4-methoxybenzyl)sulfanyl]-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine chemical structure, C26H24F3N3O3S, CAS 439094-00-5
6,7-Dimethoxy-2-[(4-methoxybenzyl)sulfanyl]-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine
CAS 439094-00-5C26H24F3N3O3S
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-6,7-dimethoxy-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine chemical structure, C25H20ClF4N3O2S, CAS 439094-05-0
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-6,7-dimethoxy-3-[3-(trifluoromethyl)benzyl]-4(3H)-quinazolinimine
CAS 439094-05-0C25H20ClF4N3O2S
3-(2-Chlorobenzyl)-2-[(2,4-dichlorobenzyl)sulfanyl]-6,7-dimethoxy-4(3H)-quinazolinimine chemical structure, C24H20Cl3N3O2S, CAS 866144-96-9
3-(2-Chlorobenzyl)-2-[(2,4-dichlorobenzyl)sulfanyl]-6,7-dimethoxy-4(3H)-quinazolinimine
CAS 866144-96-9C24H20Cl3N3O2S
3-(3-Chloro-4-methoxybenzyl)-6,7-dimethoxy-2-{[3-(trifluoromethyl)benzyl]sulfanyl}-4(3H)-quinazolinimine chemical structure, C26H23ClF3N3O3S, CAS 439121-06-9
3-(3-Chloro-4-methoxybenzyl)-6,7-dimethoxy-2-{[3-(trifluoromethyl)benzyl]sulfanyl}-4(3H)-quinazolinimine
CAS 439121-06-9C26H23ClF3N3O3S
3-(3-Chloro-4-methoxybenzyl)-2-[(2,5-dimethylbenzyl)sulfanyl]-6,7-dimethoxy-4(3H)-quinazolinimine chemical structure, C27H28ClN3O3S, CAS 439121-07-0
3-(3-Chloro-4-methoxybenzyl)-2-[(2,5-dimethylbenzyl)sulfanyl]-6,7-dimethoxy-4(3H)-quinazolinimine
CAS 439121-07-0C27H28ClN3O3S
2-{[4-(tert-Butyl)benzyl]sulfanyl}-3-(2-chlorobenzyl)-6,7-dimethoxy-4(3H)-quinazolinimine chemical structure, C28H30ClN3O2S, CAS 866144-94-7
2-{[4-(tert-Butyl)benzyl]sulfanyl}-3-(2-chlorobenzyl)-6,7-dimethoxy-4(3H)-quinazolinimine
CAS 866144-94-7C28H30ClN3O2S