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Murcko scaffold

4-Phenyl-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione scaffold

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
24
With full pages
3
Scaffold SMILES

S=c1[nH]nc(-c2cccs2)n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenyl-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione page
Murcko scaffold S=c1[nH]nc(-c2cccs2)n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

4-(2-Methylphenyl)-5-(2-thienyl)-1,2,4-triazole-3-thiol chemical structure, C13H11N3S2, CAS 681840-91-5
4-(2-Methylphenyl)-5-(2-thienyl)-1,2,4-triazole-3-thiol
CAS 681840-91-5C13H11N3S2
4-Phenyl-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C12H9N3S2, CAS 57600-04-1
4-Phenyl-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 57600-04-1C12H9N3S2
4-(2,4-Dimethylphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H13N3S2, CAS 364596-54-3
4-(2,4-Dimethylphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol
CAS 364596-54-3C14H13N3S2
4-(4-Fluorophenyl)-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione chemical structure, C12H8FN3S2, CAS 337472-33-0
4-(4-Fluorophenyl)-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione
CAS 337472-33-0C12H8FN3S2
4-(2,5-Dimethylphenyl)-3-(3-methylthiophen-2-yl)-1H-1,2,4-triazole-5-thione chemical structure, C15H15N3S2, CAS 438236-18-1
4-(2,5-Dimethylphenyl)-3-(3-methylthiophen-2-yl)-1H-1,2,4-triazole-5-thione
CAS 438236-18-1C15H15N3S2
4-(3-Methylphenyl)-3-(3-methylthiophen-2-yl)-1H-1,2,4-triazole-5-thione chemical structure, C14H13N3S2, CAS 438232-83-8
4-(3-Methylphenyl)-3-(3-methylthiophen-2-yl)-1H-1,2,4-triazole-5-thione
CAS 438232-83-8C14H13N3S2
4-(2-Methoxyphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol chemical structure, C13H11N3OS2, CAS 380574-16-3
4-(2-Methoxyphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol
CAS 380574-16-3C13H11N3OS2
3-Thiophen-2-yl-4-[2-(trifluoromethyl)phenyl]-1H-1,2,4-triazole-5-thione chemical structure, C13H8F3N3S2, CAS 672332-42-2
3-Thiophen-2-yl-4-[2-(trifluoromethyl)phenyl]-1H-1,2,4-triazole-5-thione
CAS 672332-42-2C13H8F3N3S2
4-(4-Methylphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol chemical structure, C13H11N3S2, CAS 496787-40-7
4-(4-Methylphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol
CAS 496787-40-7C13H11N3S2
4-(4-Methoxyphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol chemical structure, C13H11N3OS2, CAS 209670-96-2
4-(4-Methoxyphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol
CAS 209670-96-2C13H11N3OS2
4-(2-Bromo-4-methylphenyl)-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione chemical structure, C13H10BrN3S2, CAS 728013-67-0
4-(2-Bromo-4-methylphenyl)-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione
CAS 728013-67-0C13H10BrN3S2
4-(5-Chloro-2-methoxyphenyl)-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione chemical structure, C13H10ClN3OS2, CAS 728013-09-0
4-(5-Chloro-2-methoxyphenyl)-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione
CAS 728013-09-0C13H10ClN3OS2
4-(5-Sulfanylidene-3-thiophen-2-yl-1H-1,2,4-triazol-4-yl)benzenesulfonamide chemical structure, C12H10N4O2S3, CAS 525581-97-9
4-(5-Sulfanylidene-3-thiophen-2-yl-1H-1,2,4-triazol-4-yl)benzenesulfonamide
CAS 525581-97-9C12H10N4O2S3
4-(4-Butylphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol chemical structure, C16H17N3S2, CAS 525581-96-8
4-(4-Butylphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol
CAS 525581-96-8C16H17N3S2
4-(2,5-Dimethoxyphenyl)-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione chemical structure, C14H13N3O2S2, CAS 728034-95-5
4-(2,5-Dimethoxyphenyl)-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione
CAS 728034-95-5C14H13N3O2S2
4-(2-Methoxy-5-methylphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H13N3OS2, CAS 379728-85-5
4-(2-Methoxy-5-methylphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol
CAS 379728-85-5C14H13N3OS2
4-(4-Chlorophenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol chemical structure, C12H8ClN3S2, CAS 259154-04-6
4-(4-Chlorophenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol
CAS 259154-04-6C12H8ClN3S2
4-(3-Chloro-4-fluorophenyl)-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C12H7ClFN3S2, CAS 477334-48-8
4-(3-Chloro-4-fluorophenyl)-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 477334-48-8C12H7ClFN3S2
2-Methyl-4-phenyl-5-thiophen-2-yl-1,2,4-triazole-3-thione chemical structure, C13H11N3S2, CAS 1022482-46-7
2-Methyl-4-phenyl-5-thiophen-2-yl-1,2,4-triazole-3-thione
CAS 1022482-46-7C13H11N3S2
3-(4-Bromothiophen-2-yl)-4-(3,5-dimethylphenyl)-1H-1,2,4-triazole-5-thione chemical structure, C14H12BrN3S2, CAS 588677-87-6
3-(4-Bromothiophen-2-yl)-4-(3,5-dimethylphenyl)-1H-1,2,4-triazole-5-thione
CAS 588677-87-6C14H12BrN3S2
4-(4-Ethoxyphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H13N3OS2, CAS 893725-36-5
4-(4-Ethoxyphenyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol
CAS 893725-36-5C14H13N3OS2
4-(2,3-Dimethylphenyl)-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C14H13N3S2, CAS 1040321-56-9
4-(2,3-Dimethylphenyl)-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 1040321-56-9C14H13N3S2
4-(2,5-Dichlorophenyl)-2,4-dihydro-5-(2-thienyl)-3H-1,2,4-triazole-3-thione chemical structure, C12H7Cl2N3S2, CAS 1038300-17-2
4-(2,5-Dichlorophenyl)-2,4-dihydro-5-(2-thienyl)-3H-1,2,4-triazole-3-thione
CAS 1038300-17-2C12H7Cl2N3S2
4-[3-(3-Methylthiophen-2-yl)-5-sulfanyl-1,2,4-triazol-4-yl]benzoic acid chemical structure, C14H11N3O2S2, CAS 1010932-07-6
4-[3-(3-Methylthiophen-2-yl)-5-sulfanyl-1,2,4-triazol-4-yl]benzoic acid
CAS 1010932-07-6C14H11N3O2S2