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Murcko scaffold

Ring system with 4 rings and 24 atoms

28 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
28
With full pages
8
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2cccc(NC3CC3)c2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(c2cccc(NC3CC3)c2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

1-{3-(Cyclopropylamino)-4-nitrophenyl}-4-(2-fluorobenzoyl)piperazine chemical structure, C20H21FN4O3, CAS 347354-00-1
1-{3-(Cyclopropylamino)-4-nitrophenyl}-4-(2-fluorobenzoyl)piperazine
CAS 347354-00-1C20H21FN4O3
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(3,5-dichloro-4-methoxyphenyl)methanone chemical structure, C21H22Cl2N4O4, CAS 347353-88-2
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(3,5-dichloro-4-methoxyphenyl)methanone
CAS 347353-88-2C21H22Cl2N4O4
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(3-fluorophenyl)methanone chemical structure, C20H21FN4O3, CAS 347355-47-9
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(3-fluorophenyl)methanone
CAS 347355-47-9C20H21FN4O3
(4-Bromophenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C20H21BrN4O3, CAS 333425-23-3
(4-Bromophenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 333425-23-3C20H21BrN4O3
(2-Chloro-4,5-difluorophenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C20H19ClF2N4O3, CAS 347355-42-4
(2-Chloro-4,5-difluorophenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 347355-42-4C20H19ClF2N4O3
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(4-methoxyphenyl)methanone chemical structure, C21H24N4O4, CAS 347355-48-0
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(4-methoxyphenyl)methanone
CAS 347355-48-0C21H24N4O4
(2-Chlorophenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C20H21ClN4O3, CAS 347355-05-9
(2-Chlorophenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 347355-05-9C20H21ClN4O3
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(2-methoxyphenyl)methanone chemical structure, C21H24N4O4, CAS 347355-29-7
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(2-methoxyphenyl)methanone
CAS 347355-29-7C21H24N4O4
(3-Bromo-4-methoxyphenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C21H23BrN4O4, CAS 347308-98-9
(3-Bromo-4-methoxyphenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 347308-98-9C21H23BrN4O4
(3-Chloro-4-methoxyphenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C21H23ClN4O4, CAS 347309-03-9
(3-Chloro-4-methoxyphenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 347309-03-9C21H23ClN4O4
(2-Bromophenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C20H21BrN4O3, CAS 347354-75-0
(2-Bromophenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 347354-75-0C20H21BrN4O3
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-phenylmethanone chemical structure, C20H22N4O3, CAS 430454-46-9
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-phenylmethanone
CAS 430454-46-9C20H22N4O3
(3-Chlorophenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C20H21ClN4O3, CAS 430455-51-9
(3-Chlorophenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 430455-51-9C20H21ClN4O3
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(3-methylphenyl)methanone chemical structure, C21H24N4O3, CAS 430458-90-5
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(3-methylphenyl)methanone
CAS 430458-90-5C21H24N4O3
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(3,4-dimethoxyphenyl)methanone chemical structure, C22H26N4O5, CAS 430450-66-1
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(3,4-dimethoxyphenyl)methanone
CAS 430450-66-1C22H26N4O5
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(4-fluorophenyl)methanone chemical structure, C20H21FN4O3, CAS 430450-80-9
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(4-fluorophenyl)methanone
CAS 430450-80-9C20H21FN4O3
(4-tert-Butylphenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C24H30N4O3, CAS 432494-47-8
(4-tert-Butylphenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 432494-47-8C24H30N4O3
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(3-methoxyphenyl)methanone chemical structure, C21H24N4O4, CAS 432502-61-9
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(3-methoxyphenyl)methanone
CAS 432502-61-9C21H24N4O4
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(2-iodophenyl)methanone chemical structure, C20H21IN4O3, CAS 432520-22-4
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(2-iodophenyl)methanone
CAS 432520-22-4C20H21IN4O3
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(4-ethoxyphenyl)methanone chemical structure, C22H26N4O4, CAS 432530-91-1
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(4-ethoxyphenyl)methanone
CAS 432530-91-1C22H26N4O4
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(2-methylphenyl)methanone chemical structure, C21H24N4O3, CAS 432538-60-8
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(2-methylphenyl)methanone
CAS 432538-60-8C21H24N4O3
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(4-propan-2-ylphenyl)methanone chemical structure, C23H28N4O3, CAS 509113-56-8
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(4-propan-2-ylphenyl)methanone
CAS 509113-56-8C23H28N4O3
(4-Butoxyphenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C24H30N4O4, CAS 524033-95-2
(4-Butoxyphenyl)-[4-[3-(cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 524033-95-2C24H30N4O4
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(4-ethylphenyl)methanone chemical structure, C22H26N4O3, CAS 591736-73-1
[4-[3-(Cyclopropylamino)-4-nitrophenyl]piperazin-1-yl]-(4-ethylphenyl)methanone
CAS 591736-73-1C22H26N4O3