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Murcko scaffold

2',3'-Dihydro-1'H-spiro(cyclobutane-1,4'-isoquinoline) scaffold

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
13
Chemicals
16
With full pages
1
Scaffold SMILES

c1ccc2c(c1)CNCC21CCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2',3'-Dihydro-1'H-spiro(cyclobutane-1,4'-isoquinoline) page
Murcko scaffold c1ccc2c(c1)CNCC21CCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

2',3'-Dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] hydrochloride chemical structure, C12H16ClN, CAS 1159824-66-4
2',3'-Dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] hydrochloride
CAS 1159824-66-4C12H16ClN
2',3'-Dihydro-1'H-spiro(cyclobutane-1,4'-isoquinoline) chemical structure, C12H15N, CAS 850875-62-6
2',3'-Dihydro-1'H-spiro(cyclobutane-1,4'-isoquinoline)
CAS 850875-62-6C12H15N
7'-Bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] chemical structure, C12H14BrN, CAS 1314792-82-9
7'-Bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline]
CAS 1314792-82-9C12H14BrN
7'-Fluoro-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] chemical structure, C12H14FN, CAS 1283718-61-5
7'-Fluoro-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline]
CAS 1283718-61-5C12H14FN
7'-Methoxy-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] chemical structure, C13H17NO, CAS 1314790-90-3
7'-Methoxy-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline]
CAS 1314790-90-3C13H17NO
6-(Trifluoromethyl)spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclobutane] chemical structure, C13H14F3N, CAS 1314779-29-7
6-(Trifluoromethyl)spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclobutane]
CAS 1314779-29-7C13H14F3N
6'-Bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] chemical structure, C12H14BrN, CAS 1314756-12-1
6'-Bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline]
CAS 1314756-12-1C12H14BrN
6'-Methoxy-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] chemical structure, C13H17NO, CAS 1314724-02-1
6'-Methoxy-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline]
CAS 1314724-02-1C13H17NO
7'-(Trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] chemical structure, C13H14F3N, CAS 1314780-69-2
7'-(Trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline]
CAS 1314780-69-2C13H14F3N
8-(Trifluoromethyl)spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclobutane] chemical structure, C13H14F3N, CAS 1314779-32-2
8-(Trifluoromethyl)spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclobutane]
CAS 1314779-32-2C13H14F3N
7'-Chloro-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] chemical structure, C12H14ClN, CAS 1314787-35-3
7'-Chloro-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline]
CAS 1314787-35-3C12H14ClN
2',3'-Dihydro-1'H-spiro[cyclobutane-1,4'-isoquinolin]-6'-amine chemical structure, C12H16N2, CAS 1314780-70-5
2',3'-Dihydro-1'H-spiro[cyclobutane-1,4'-isoquinolin]-6'-amine
CAS 1314780-70-5C12H16N2
8'-Bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] chemical structure, C12H14BrN, CAS 1314779-45-7
8'-Bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline]
CAS 1314779-45-7C12H14BrN
6'-Bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] hydrochloride chemical structure, C12H15BrClN, CAS 1314670-57-9
6'-Bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] hydrochloride
CAS 1314670-57-9C12H15BrClN
8'-Bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] hydrochloride chemical structure, C12H15BrClN, CAS 1314660-11-1
8'-Bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] hydrochloride
CAS 1314660-11-1C12H15BrClN
7'-Chloro-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] hydrochloride chemical structure, C12H15Cl2N, CAS 1314796-44-5
7'-Chloro-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoline] hydrochloride
CAS 1314796-44-5C12H15Cl2N