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Murcko scaffold

Ring system with 4 rings and 27 atoms

19 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
19
With full pages
3
Scaffold SMILES

O=C(NCc1nnnn1-c1ccccc1)C1CC(=O)N(c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCc1nnnn1-c1ccccc1)C1CC(=O)N(c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

N-((1-(3,4-Dimethylphenyl)-1H-tetrazol-5-yl)methyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C21H22N6O2, CAS 933001-98-0
N-((1-(3,4-Dimethylphenyl)-1H-tetrazol-5-yl)methyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide
CAS 933001-98-0C21H22N6O2
N-((1-(3,4-Dimethylphenyl)-1H-tetrazol-5-yl)methyl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide chemical structure, C22H24N6O2, CAS 933222-36-7
N-((1-(3,4-Dimethylphenyl)-1H-tetrazol-5-yl)methyl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide
CAS 933222-36-7C22H24N6O2
N-{[1-(3,4-Dimethylphenyl)-1H-1,2,3,4-tetrazol-5-yl]methyl}-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H21FN6O2, CAS 897614-39-0
N-{[1-(3,4-Dimethylphenyl)-1H-1,2,3,4-tetrazol-5-yl]methyl}-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 897614-39-0C21H21FN6O2
1-(4-Chlorophenyl)-N-((1-(3,4-dimethylphenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H21ClN6O2, CAS 897614-41-4
1-(4-Chlorophenyl)-N-((1-(3,4-dimethylphenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide
CAS 897614-41-4C21H21ClN6O2
1-(4-Chlorophenyl)-N-{[1-(4-chlorophenyl)-1H-1,2,3,4-tetrazol-5-yl]methyl}-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16Cl2N6O2, CAS 897623-30-2
1-(4-Chlorophenyl)-N-{[1-(4-chlorophenyl)-1H-1,2,3,4-tetrazol-5-yl]methyl}-5-oxopyrrolidine-3-carboxamide
CAS 897623-30-2C19H16Cl2N6O2
1-(4-Fluorophenyl)-N-((1-(4-fluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16F2N6O2, CAS 897623-76-6
1-(4-Fluorophenyl)-N-((1-(4-fluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide
CAS 897623-76-6C19H16F2N6O2
1-(4-Ethoxyphenyl)-N-((1-(4-ethoxyphenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C23H26N6O4, CAS 921073-53-2
1-(4-Ethoxyphenyl)-N-((1-(4-ethoxyphenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide
CAS 921073-53-2C23H26N6O4
N-((1-(4-Ethoxyphenyl)-1H-tetrazol-5-yl)methyl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide chemical structure, C22H24N6O3, CAS 921165-21-1
N-((1-(4-Ethoxyphenyl)-1H-tetrazol-5-yl)methyl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide
CAS 921165-21-1C22H24N6O3
1-(3,4-Dimethylphenyl)-N-((1-(4-ethoxyphenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C23H26N6O3, CAS 921053-87-4
1-(3,4-Dimethylphenyl)-N-((1-(4-ethoxyphenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide
CAS 921053-87-4C23H26N6O3
1-(4-Ethoxyphenyl)-5-oxo-N-((1-(p-tolyl)-1H-tetrazol-5-yl)methyl)pyrrolidine-3-carboxamide chemical structure, C22H24N6O3, CAS 921074-55-7
1-(4-Ethoxyphenyl)-5-oxo-N-((1-(p-tolyl)-1H-tetrazol-5-yl)methyl)pyrrolidine-3-carboxamide
CAS 921074-55-7C22H24N6O3
5-Oxo-1-(p-tolyl)-N-((1-(p-tolyl)-1H-tetrazol-5-yl)methyl)pyrrolidine-3-carboxamide chemical structure, C21H22N6O2, CAS 920461-34-3
5-Oxo-1-(p-tolyl)-N-((1-(p-tolyl)-1H-tetrazol-5-yl)methyl)pyrrolidine-3-carboxamide
CAS 920461-34-3C21H22N6O2
1-(4-Chlorophenyl)-5-oxo-N-((1-phenyl-1H-tetrazol-5-yl)methyl)pyrrolidine-3-carboxamide chemical structure, C19H17ClN6O2, CAS 921166-76-9
1-(4-Chlorophenyl)-5-oxo-N-((1-phenyl-1H-tetrazol-5-yl)methyl)pyrrolidine-3-carboxamide
CAS 921166-76-9C19H17ClN6O2
1-(4-Ethoxyphenyl)-N-((1-(3-fluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H21FN6O3, CAS 921501-80-6
1-(4-Ethoxyphenyl)-N-((1-(3-fluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide
CAS 921501-80-6C21H21FN6O3
N-((1-(3,4-Difluorophenyl)-1H-tetrazol-5-yl)methyl)-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H15F3N6O2, CAS 942000-14-8
N-((1-(3,4-Difluorophenyl)-1H-tetrazol-5-yl)methyl)-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 942000-14-8C19H15F3N6O2
1-(4-Chlorophenyl)-N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H15ClF2N6O2, CAS 941922-30-1
1-(4-Chlorophenyl)-N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide
CAS 941922-30-1C19H15ClF2N6O2
N-((1-(3,4-Difluorophenyl)-1H-tetrazol-5-yl)methyl)-1-(3,4-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H20F2N6O2, CAS 1005306-61-5
N-((1-(3,4-Difluorophenyl)-1H-tetrazol-5-yl)methyl)-1-(3,4-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 1005306-61-5C21H20F2N6O2
1-(4-Chlorophenyl)-N-((1-(4-fluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16ClFN6O2, CAS 941875-03-2
1-(4-Chlorophenyl)-N-((1-(4-fluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide
CAS 941875-03-2C19H16ClFN6O2
1-(3,4-Dimethylphenyl)-N-{[1-(4-methoxyphenyl)-1H-1,2,3,4-tetrazol-5-yl]methyl}-5-oxopyrrolidine-3-carboxamide chemical structure, C22H24N6O3, CAS 946308-28-7
1-(3,4-Dimethylphenyl)-N-{[1-(4-methoxyphenyl)-1H-1,2,3,4-tetrazol-5-yl]methyl}-5-oxopyrrolidine-3-carboxamide
CAS 946308-28-7C22H24N6O3
1-(4-Fluorophenyl)-N-((1-(3-fluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16F2N6O2, CAS 921501-83-9
1-(4-Fluorophenyl)-N-((1-(3-fluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide
CAS 921501-83-9C19H16F2N6O2