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Murcko scaffold

Ring system with 4 rings and 28 atoms

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
13
With full pages
3
Scaffold SMILES

O=C1CC(N2CCN(CC=Cc3ccccc3)CC2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(N2CCN(CC=Cc3ccccc3)CC2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

1-(3-Chlorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C23H24ClN3O2, CAS 301354-79-0
1-(3-Chlorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidine-2,5-dione
CAS 301354-79-0C23H24ClN3O2
1-(4-Chlorophenyl)-3-(4-cinnamyl-1-piperazinyl)-2,5-pyrrolidinedione chemical structure, C23H24ClN3O2, CAS 313705-19-0
1-(4-Chlorophenyl)-3-(4-cinnamyl-1-piperazinyl)-2,5-pyrrolidinedione
CAS 313705-19-0C23H24ClN3O2
1-(4-Bromophenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidine-2,5-dione chemical structure, C23H24BrN3O2, CAS 300730-75-0
1-(4-Bromophenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidine-2,5-dione
CAS 300730-75-0C23H24BrN3O2
1-(3-Methoxyphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C24H27N3O3, CAS 296769-65-8
1-(3-Methoxyphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidine-2,5-dione
CAS 296769-65-8C24H27N3O3
Ethyl 4-(2,5-dioxo-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidin-1-yl)benzoate chemical structure, C26H29N3O4, CAS 1164109-59-4
Ethyl 4-(2,5-dioxo-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidin-1-yl)benzoate
CAS 1164109-59-4C26H29N3O4
3-[4-[(E)-3-Phenylprop-2-enyl]piperazin-1-yl]-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2,5-dione chemical structure, C24H24F3N3O2, CAS 590378-39-5
3-[4-[(E)-3-Phenylprop-2-enyl]piperazin-1-yl]-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2,5-dione
CAS 590378-39-5C24H24F3N3O2
1-(3-Chloro-4-methylphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C24H26ClN3O2, CAS 330865-14-0
1-(3-Chloro-4-methylphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidine-2,5-dione
CAS 330865-14-0C24H26ClN3O2
4-(2,5-Dioxo-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidin-1-yl)benzoic acid chemical structure, C24H25N3O4, CAS 313378-49-3
4-(2,5-Dioxo-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidin-1-yl)benzoic acid
CAS 313378-49-3C24H25N3O4
1-(4-Methoxyphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C24H27N3O3, CAS 313377-59-2
1-(4-Methoxyphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidine-2,5-dione
CAS 313377-59-2C24H27N3O3
Methyl 4-[2,5-dioxo-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidin-1-yl]benzoate chemical structure, C25H27N3O4, CAS 330865-45-7
Methyl 4-[2,5-dioxo-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidin-1-yl]benzoate
CAS 330865-45-7C25H27N3O4
1-(4-Butoxyphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C27H33N3O3, CAS 312505-54-7
1-(4-Butoxyphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]pyrrolidine-2,5-dione
CAS 312505-54-7C27H33N3O3
Butyl 4-(2,5-dioxo-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidin-1-yl)benzoate chemical structure, C28H33N3O4, CAS 1164115-75-6
Butyl 4-(2,5-dioxo-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidin-1-yl)benzoate
CAS 1164115-75-6C28H33N3O4
1-(2,4-Difluorophenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidine-2,5-dione chemical structure, C23H23F2N3O2, CAS 329059-09-8
1-(2,4-Difluorophenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidine-2,5-dione
CAS 329059-09-8C23H23F2N3O2