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Murcko scaffold

Ring system with 4 rings and 25 atoms

42 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
42
With full pages
4
Scaffold SMILES

O=C(CSc1nnc(-c2cc3ccccc3o2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(-c2cc3ccccc3o2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

2-{[4-Amino-5-(7-methoxy-1-benzofuran-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2,5-dichlorophenyl)acetamide chemical structure, C19H15Cl2N5O3S, CAS 665018-85-9
2-{[4-Amino-5-(7-methoxy-1-benzofuran-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2,5-dichlorophenyl)acetamide
CAS 665018-85-9C19H15Cl2N5O3S
2-{[4-Amino-5-(7-methoxy-1-benzofuran-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-methylphenyl)acetamide chemical structure, C20H19N5O3S, CAS 694507-59-0
2-{[4-Amino-5-(7-methoxy-1-benzofuran-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-methylphenyl)acetamide
CAS 694507-59-0C20H19N5O3S
2-[[5-(5-Chloro-1-benzofuran-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-fluorophenyl)acetamide chemical structure, C21H16ClFN4O2S, CAS 823836-01-7
2-[[5-(5-Chloro-1-benzofuran-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-fluorophenyl)acetamide
CAS 823836-01-7C21H16ClFN4O2S
2-[[5-(1-Benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-bromophenyl)acetamide chemical structure, C19H15BrN4O2S, CAS 713492-90-1
2-[[5-(1-Benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-bromophenyl)acetamide
CAS 713492-90-1C19H15BrN4O2S
2-[[5-(1-Benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-fluorophenyl)acetamide chemical structure, C19H15FN4O2S, CAS 713492-91-2
2-[[5-(1-Benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-fluorophenyl)acetamide
CAS 713492-91-2C19H15FN4O2S
N-(3-Bromophenyl)-2-[[5-(7-methoxy-2-benzofuranyl)-4-methyl-1,2,4-triazol-3-yl]thio]acetamide chemical structure, C20H17BrN4O3S, CAS 713493-69-7
N-(3-Bromophenyl)-2-[[5-(7-methoxy-2-benzofuranyl)-4-methyl-1,2,4-triazol-3-yl]thio]acetamide
CAS 713493-69-7C20H17BrN4O3S
N-(3-Fluorophenyl)-2-[[5-(7-methoxy-1-benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C20H17FN4O3S, CAS 713493-98-2
N-(3-Fluorophenyl)-2-[[5-(7-methoxy-1-benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 713493-98-2C20H17FN4O3S
2-[[4-Amino-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-iodophenyl)acetamide chemical structure, C19H16IN5O3S, CAS 714213-88-4
2-[[4-Amino-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-iodophenyl)acetamide
CAS 714213-88-4C19H16IN5O3S
N-(2,4-Dichlorophenyl)-2-[[4-ethyl-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C21H18Cl2N4O3S, CAS 694507-06-7
N-(2,4-Dichlorophenyl)-2-[[4-ethyl-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 694507-06-7C21H18Cl2N4O3S
N-(2,4-Dimethylphenyl)-2-[[4-ethyl-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C23H24N4O3S, CAS 694507-18-1
N-(2,4-Dimethylphenyl)-2-[[4-ethyl-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 694507-18-1C23H24N4O3S
2-[[5-(7-Methoxy-1-benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-phenylacetamide chemical structure, C20H18N4O3S, CAS 694508-44-6
2-[[5-(7-Methoxy-1-benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-phenylacetamide
CAS 694508-44-6C20H18N4O3S
2-[[5-(1-Benzofuran-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3,4-dimethylphenyl)acetamide chemical structure, C23H22N4O2S, CAS 701275-70-9
2-[[5-(1-Benzofuran-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3,4-dimethylphenyl)acetamide
CAS 701275-70-9C23H22N4O2S
2-[[5-(5-Chloro-1-benzofuran-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methoxyphenyl)acetamide chemical structure, C22H19ClN4O3S, CAS 767323-93-3
2-[[5-(5-Chloro-1-benzofuran-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methoxyphenyl)acetamide
CAS 767323-93-3C22H19ClN4O3S
2-[[5-(5-Chloro-1-benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C20H14ClF3N4O2S, CAS 708999-28-4
2-[[5-(5-Chloro-1-benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 708999-28-4C20H14ClF3N4O2S
N-(2-Bromo-4,6-difluorophenyl)-2-[[5-(7-methoxy-1-benzofuran-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C22H17BrF2N4O3S, CAS 709003-60-1
N-(2-Bromo-4,6-difluorophenyl)-2-[[5-(7-methoxy-1-benzofuran-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 709003-60-1C22H17BrF2N4O3S
Methyl 2-[({[5-(7-methoxy-1-benzofuran-2-yl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetyl)amino]benzoate chemical structure, C22H20N4O5S, CAS 709004-85-3
Methyl 2-[({[5-(7-methoxy-1-benzofuran-2-yl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetyl)amino]benzoate
CAS 709004-85-3C22H20N4O5S
N-(3,4-Dichlorophenyl)-2-[[4-ethyl-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C21H18Cl2N4O3S, CAS 694484-78-1
N-(3,4-Dichlorophenyl)-2-[[4-ethyl-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 694484-78-1C21H18Cl2N4O3S
N-(3,4-Dimethylphenyl)-2-[[4-ethyl-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C23H24N4O3S, CAS 694497-44-4
N-(3,4-Dimethylphenyl)-2-[[4-ethyl-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 694497-44-4C23H24N4O3S
2-[[4-Amino-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methoxy-5-methylphenyl)acetamide chemical structure, C21H21N5O4S, CAS 694502-67-5
2-[[4-Amino-5-(7-methoxy-1-benzofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methoxy-5-methylphenyl)acetamide
CAS 694502-67-5C21H21N5O4S
2-[[5-(5-Bromo-1-benzofuran-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-ethyl-6-methylphenyl)acetamide chemical structure, C23H23BrN4O2S, CAS 701952-76-3
2-[[5-(5-Bromo-1-benzofuran-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-ethyl-6-methylphenyl)acetamide
CAS 701952-76-3C23H23BrN4O2S
2-[[5-(5-Bromo-1-benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(5-chloro-2-methoxyphenyl)acetamide chemical structure, C20H16BrClN4O3S, CAS 701970-51-6
2-[[5-(5-Bromo-1-benzofuran-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(5-chloro-2-methoxyphenyl)acetamide
CAS 701970-51-6C20H16BrClN4O3S
2-[[5-(5-Bromo-1-benzofuran-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methyl-5-nitrophenyl)acetamide chemical structure, C22H18BrN5O4S, CAS 706778-01-0
2-[[5-(5-Bromo-1-benzofuran-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methyl-5-nitrophenyl)acetamide
CAS 706778-01-0C22H18BrN5O4S
Ethyl 3-[({[5-(7-methoxy-1-benzofuran-2-yl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetyl)amino]benzoate chemical structure, C23H22N4O5S, CAS 708250-57-1
Ethyl 3-[({[5-(7-methoxy-1-benzofuran-2-yl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetyl)amino]benzoate
CAS 708250-57-1C23H22N4O5S
2-[[5-(5-Bromo-1-benzofuran-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-methylsulfanylphenyl)acetamide chemical structure, C21H19BrN4O2S2, CAS 708243-36-1
2-[[5-(5-Bromo-1-benzofuran-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-methylsulfanylphenyl)acetamide
CAS 708243-36-1C21H19BrN4O2S2