Murcko scaffold
Ring system with 3 rings and 18 atoms
27 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 18
- Chemicals
- 27
- With full pages
- 13
Scaffold SMILES
O=C1NC(=S)SC1=CC1=Cc2ccccc2OC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 27 of 27 chemicals
(5Z)-3-Butyl-5-(2H-chromen-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 371120-14-8C17H17NO2S2
(5Z)-5-(2H-Chromen-3-ylmethylene)-3-isopropyl-2-thioxo-1,3-thiazolidin-4-one
CAS 384373-85-7C16H15NO2S2
(5Z)-5-(2H-Chromen-3-ylmethylene)-3-(3-methoxypropyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 371141-87-6C17H17NO3S2
(Z)-5-((2H-Chromen-3-yl)methylene)-3-methyl-2-thioxothiazolidin-4-one
CAS 618074-90-1C14H11NO2S2
5-(2H-Chromen-3-ylmethylene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
CAS 618075-02-8C15H13NO2S2
5-(2H-Chromen-3-ylmethylene)-3-(2-ethylhexyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 618074-74-1C21H25NO2S2
![(5Z)-3-(3-Methoxypropyl)-5-[(2-methyl-2H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H19NO3S2, CAS 371135-19-2](/s/DMYLSUFHRMMFLE-WJDWOHSUSA-N.svg)
(5Z)-3-(3-Methoxypropyl)-5-[(2-methyl-2H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
CAS 371135-19-2C18H19NO3S2
5-(2H-Chromen-3-ylmethylene)-3-pentyl-2-thioxo-1,3-thiazolidin-4-one
CAS 618076-44-1C18H19NO2S2
![(5Z)-3-Isobutyl-5-[(2-methyl-2H-chromen-3-yl)methylene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H19NO2S2, CAS 384369-58-8](/s/KMWBFXBSRJZTLE-SXGWCWSVSA-N.svg)
(5Z)-3-Isobutyl-5-[(2-methyl-2H-chromen-3-yl)methylene]-2-thioxo-1,3-thiazolidin-4-one
CAS 384369-58-8C18H19NO2S2
![2-[(5Z)-5-(2H-Chromen-3-ylmethylene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]ethanesulfonic acid chemical structure, C15H13NO5S3, CAS 618077-55-7](/s/YFGBJUZWFSVVBI-JYRVWZFOSA-N.svg)
2-[(5Z)-5-(2H-Chromen-3-ylmethylene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]ethanesulfonic acid
CAS 618077-55-7C15H13NO5S3
![3-[(5Z)-5-[(2-Methyl-2H-chromen-3-yl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid chemical structure, C17H15NO4S2, CAS 384366-42-1](/s/OPJMPDNYXRIESN-ZROIWOOFSA-N.svg)
3-[(5Z)-5-[(2-Methyl-2H-chromen-3-yl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
CAS 384366-42-1C17H15NO4S2
(Z)-5-((2-Methyl-2H-chromen-3-yl)methylene)-2-thioxothiazolidin-4-one
CAS 620579-20-6C14H11NO2S2
(5Z)-5-(2H-Chromen-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 1422655-51-3C13H9NO2S2
![6-{(5Z)-5-[(2-Methyl-2H-chromen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}hexanoic acid chemical structure, C20H21NO4S2, CAS 519012-34-1](/s/XHFYPQOHZOWMFW-ATVHPVEESA-N.svg)
6-{(5Z)-5-[(2-Methyl-2H-chromen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}hexanoic acid
CAS 519012-34-1C20H21NO4S2
3-sec-Butyl-5-(2H-chromen-3-ylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 618074-76-3C17H17NO2S2
5-(2H-Chromen-3-ylmethylene)-3-isobutyl-2-thioxo-1,3-thiazolidin-4-one
CAS 618074-98-9C17H17NO2S2
![(5Z)-5-[(2-Methyl-2H-chromen-3-yl)methylidene]-3-propyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H17NO2S2, CAS 371232-91-6](/s/XEGKDHKVJSUJPK-GDNBJRDFSA-N.svg)
(5Z)-5-[(2-Methyl-2H-chromen-3-yl)methylidene]-3-propyl-2-thioxo-1,3-thiazolidin-4-one
CAS 371232-91-6C17H17NO2S2
![(5Z)-5-[(2-Methyl-2H-chromen-3-yl)methylidene]-3-pentyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H21NO2S2, CAS 371209-15-3](/s/HAWIOOWCUQUZJX-ATVHPVEESA-N.svg)
(5Z)-5-[(2-Methyl-2H-chromen-3-yl)methylidene]-3-pentyl-2-thioxo-1,3-thiazolidin-4-one
CAS 371209-15-3C19H21NO2S2
![(5Z)-5-[(2-Methyl-2H-chromen-3-yl)methylidene]-3-octyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C22H27NO2S2, CAS 370869-47-9](/s/ZWODRVIEYUIRNP-HKWRFOASSA-N.svg)
(5Z)-5-[(2-Methyl-2H-chromen-3-yl)methylidene]-3-octyl-2-thioxo-1,3-thiazolidin-4-one
CAS 370869-47-9C22H27NO2S2
![(5Z)-3-Ethyl-5-[(2-methyl-2H-chromen-3-yl)methylene]-2-thioxo-thiazolidin-4-one chemical structure, C16H15NO2S2, CAS 370582-46-0](/s/AAPHNFJLVIIBFG-ZROIWOOFSA-N.svg)
(5Z)-3-Ethyl-5-[(2-methyl-2H-chromen-3-yl)methylene]-2-thioxo-thiazolidin-4-one
CAS 370582-46-0C16H15NO2S2
![(5Z)-3-Butyl-5-[(2-methyl-2H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H19NO2S2, CAS 385390-00-1](/s/DPGCZJINSBYQSW-WJDWOHSUSA-N.svg)
(5Z)-3-Butyl-5-[(2-methyl-2H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
CAS 385390-00-1C18H19NO2S2
![(5Z)-3-Hexyl-5-[(2-methyl-2H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H23NO2S2, CAS 500274-20-4](/s/QTAUDCQKLKEGPA-AQTBWJFISA-N.svg)
(5Z)-3-Hexyl-5-[(2-methyl-2H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
CAS 500274-20-4C20H23NO2S2
5-(2H-Chromen-3-ylmethylene)-3-(3-ethoxypropyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 618074-86-5C18H19NO3S2
3-Allyl-5-(2H-chromen-3-ylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 618075-00-6C16H13NO2S2
Related scaffolds
Same ring framework with different atoms or bond orders
O=C1NC(=S)SC1=Cc1cnc2ccccn2c1=O38 chemicals
O=S(=O)(c1cccs1)N1CCc2ccccc2C17 chemicals
O=C(c1cccs1)N1CCc2ccccc2C16 chemicals
c1csc(Cc2ccc3cccnc3c2)c15 chemicals
c1cnc2cc(NC3=NCCN3)ccc2n15 chemicals
O=C(c1cc2ccccc2oc1=O)n1cccn14 chemicals
O=c1ccc2cc(CN3CCCC3)ccc2o13 chemicals![Scaffold O=c1c2ccccc2[nH]c(=S)n1Cc1ccco1](/scaffold/DZUDSAYOEVFSAS-UHFFFAOYSA-N/structure.svg)
O=c1c2ccccc2[nH]c(=S)n1Cc1ccco13 chemicals
O=S(=O)(c1ccc2ccccc2c1)n1ccnc13 chemicals
O=C(c1ccco1)N1CCc2ccccc2C13 chemicals
c1ccc2nc(Cn3cccn3)ccc2c13 chemicals
O=S(=O)(c1ccc2ccccc2c1)N1CCCC13 chemicals