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Murcko scaffold

3,4-Dihydro-1H-isoquinolin-2-yl(thiophen-2-yl)methanone scaffold

20 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
20
With full pages
6
Scaffold SMILES

O=C(c1cccs1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3,4-Dihydro-1H-isoquinolin-2-yl(thiophen-2-yl)methanone page
Murcko scaffold O=C(c1cccs1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

3,4-Dihydro-1H-isoquinolin-2-yl(thiophen-2-yl)methanone chemical structure, C14H13NOS, CAS 349097-64-9
3,4-Dihydro-1H-isoquinolin-2-yl(thiophen-2-yl)methanone
CAS 349097-64-9C14H13NOS
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(thiophen-2-yl)methanone chemical structure, C16H17NO3S, CAS 883945-35-5
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(thiophen-2-yl)methanone
CAS 883945-35-5C16H17NO3S
(3,4-Dihydroisoquinolin-2(1H)-yl)(5-nitrothiophen-2-yl)methanone chemical structure, C14H12N2O3S, CAS 329903-15-3
(3,4-Dihydroisoquinolin-2(1H)-yl)(5-nitrothiophen-2-yl)methanone
CAS 329903-15-3C14H12N2O3S
Ethyl 2-amino-5-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-4-methylthiophene-3-carboxylate chemical structure, C18H20N2O3S, CAS 346714-19-0
Ethyl 2-amino-5-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-4-methylthiophene-3-carboxylate
CAS 346714-19-0C18H20N2O3S
(5-Chlorothiophen-2-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone chemical structure, C14H12ClNOS, CAS 495377-76-9
(5-Chlorothiophen-2-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone
CAS 495377-76-9C14H12ClNOS
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(3-methylthiophen-2-yl)methanone chemical structure, C17H19NO3S, CAS 883952-05-4
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(3-methylthiophen-2-yl)methanone
CAS 883952-05-4C17H19NO3S
(5-Bromothiophen-2-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone chemical structure, C14H12BrNOS, CAS 777878-76-9
(5-Bromothiophen-2-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone
CAS 777878-76-9C14H12BrNOS
Ethyl (2-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)carbamate chemical structure, C17H18N2O3S, CAS 955641-27-7
Ethyl (2-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)carbamate
CAS 955641-27-7C17H18N2O3S
2-Methoxy-N-(2-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide chemical structure, C17H18N2O3S, CAS 955763-01-6
2-Methoxy-N-(2-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide
CAS 955763-01-6C17H18N2O3S
2-Ethoxy-N-(2-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide chemical structure, C18H20N2O3S, CAS 955641-61-9
2-Ethoxy-N-(2-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide
CAS 955641-61-9C18H20N2O3S
N-(2-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide chemical structure, C16H16N2O2S, CAS 955763-17-4
N-(2-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide
CAS 955763-17-4C16H16N2O2S
N-(2-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)isobutyramide chemical structure, C18H20N2O2S, CAS 955641-79-9
N-(2-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)isobutyramide
CAS 955641-79-9C18H20N2O2S
N-(2-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)methanesulfonamide chemical structure, C15H16N2O3S2, CAS 955725-33-4
N-(2-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)methanesulfonamide
CAS 955725-33-4C15H16N2O3S2
N-(2-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)propane-2-sulfonamide chemical structure, C17H20N2O3S2, CAS 955726-51-9
N-(2-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)propane-2-sulfonamide
CAS 955726-51-9C17H20N2O3S2
2-(2-Thienylcarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-amine chemical structure, C14H14N2OS, CAS 1017675-00-1
2-(2-Thienylcarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-amine
CAS 1017675-00-1C14H14N2OS
(7-Nitro-3,4-dihydroisoquinolin-2(1H)-yl)(thiophen-2-yl)methanone chemical structure, C14H12N2O3S, CAS 1170393-93-7
(7-Nitro-3,4-dihydroisoquinolin-2(1H)-yl)(thiophen-2-yl)methanone
CAS 1170393-93-7C14H12N2O3S
Ethyl 4-oxo-4-((2-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)butanoate chemical structure, C20H22N2O4S, CAS 1207039-29-9
Ethyl 4-oxo-4-((2-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)butanoate
CAS 1207039-29-9C20H22N2O4S
Ethyl 2-{[5-(methylsulfanyl)thiophen-2-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylate chemical structure, C18H19NO3S2, CAS 1254944-66-5
Ethyl 2-{[5-(methylsulfanyl)thiophen-2-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
CAS 1254944-66-5C18H19NO3S2
(4-Chlorothiophen-2-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone chemical structure, C14H12ClNOS, CAS 2897216-68-9
(4-Chlorothiophen-2-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone
CAS 2897216-68-9C14H12ClNOS
(3-Chlorothiophen-2-yl)(3,4-dihydroisoquinolin-2(1H)-YL)methanone chemical structure, C14H12ClNOS, CAS 2944410-12-0
(3-Chlorothiophen-2-yl)(3,4-dihydroisoquinolin-2(1H)-YL)methanone
CAS 2944410-12-0C14H12ClNOS