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Murcko scaffold

Ring system with 5 rings and 32 atoms

7 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
32
Chemicals
7
With full pages
1
Scaffold SMILES

O=C1CC(c2ccccc2)CC2=C1C(c1ccccc1)C(C(=O)Nc1ccccc1)=CN2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)CC2=C1C(c1ccccc1)C(C(=O)Nc1ccccc1)=CN2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

N-(2,6-Difluorophenyl)-2-methyl-5-oxo-4,7-diphenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide chemical structure, C29H24F2N2O2, CAS 428502-63-0
N-(2,6-Difluorophenyl)-2-methyl-5-oxo-4,7-diphenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS 428502-63-0C29H24F2N2O2
N-(4-Fluorophenyl)-2-methyl-5-oxo-7-phenyl-4-(3,4,5-trimethoxyphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide chemical structure, C32H31FN2O5, CAS 496786-04-0
N-(4-Fluorophenyl)-2-methyl-5-oxo-7-phenyl-4-(3,4,5-trimethoxyphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS 496786-04-0C32H31FN2O5
4-(2-Chlorophenyl)-N-(3-fluorophenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide chemical structure, C29H24ClFN2O2, CAS 428823-50-1
4-(2-Chlorophenyl)-N-(3-fluorophenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS 428823-50-1C29H24ClFN2O2
N-(3-Fluorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-2-methyl-5-oxo-7-phenyl-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C30H27FN2O4, CAS 428844-38-6
N-(3-Fluorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-2-methyl-5-oxo-7-phenyl-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 428844-38-6C30H27FN2O4
N-(2-Fluorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide chemical structure, C30H27FN2O4, CAS 421567-04-6
N-(2-Fluorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS 421567-04-6C30H27FN2O4
7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-2-methyl-N-(4-methylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide chemical structure, C32H31FN2O4, CAS 847462-94-6
7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-2-methyl-N-(4-methylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
CAS 847462-94-6C32H31FN2O4
7-(3,4-Dimethoxyphenyl)-2-methyl-N-(4-methylphenyl)-4-[4-(methylsulfanyl)phenyl]-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide chemical structure, C33H34N2O4S, CAS 688057-39-8
7-(3,4-Dimethoxyphenyl)-2-methyl-N-(4-methylphenyl)-4-[4-(methylsulfanyl)phenyl]-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
CAS 688057-39-8C33H34N2O4S