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Murcko scaffold

Ring system with 3 rings and 17 atoms

34 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
34
With full pages
1
Scaffold SMILES

O=C(Nc1cc(-c2ccccc2)cs1)C1CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cc(-c2ccccc2)cs1)C1CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

Ethyl 2-(cyclopropanecarbonylamino)-4-phenylthiophene-3-carboxylate chemical structure, C17H17NO3S, CAS 312939-67-6
Ethyl 2-(cyclopropanecarbonylamino)-4-phenylthiophene-3-carboxylate
CAS 312939-67-6C17H17NO3S
Ethyl 2-[(cyclopropylcarbonyl)amino]-4-(4-methylphenyl)thiophene-3-carboxylate chemical structure, C18H19NO3S, CAS 312528-48-6
Ethyl 2-[(cyclopropylcarbonyl)amino]-4-(4-methylphenyl)thiophene-3-carboxylate
CAS 312528-48-6C18H19NO3S
Methyl 2-(cyclopropanecarbonylamino)-5-methyl-4-(4-methylphenyl)thiophene-3-carboxylate chemical structure, C18H19NO3S, CAS 496016-20-7
Methyl 2-(cyclopropanecarbonylamino)-5-methyl-4-(4-methylphenyl)thiophene-3-carboxylate
CAS 496016-20-7C18H19NO3S
Methyl 2-(cyclopropanecarbonylamino)-4-(3,4-dimethylphenyl)-5-methylthiophene-3-carboxylate chemical structure, C19H21NO3S, CAS 496016-58-1
Methyl 2-(cyclopropanecarbonylamino)-4-(3,4-dimethylphenyl)-5-methylthiophene-3-carboxylate
CAS 496016-58-1C19H21NO3S
Isopropyl 2-[(cyclopropylcarbonyl)amino]-4-(4-fluorophenyl)-5-methyl-3-thiophenecarboxylate chemical structure, C19H20FNO3S, CAS 495381-96-9
Isopropyl 2-[(cyclopropylcarbonyl)amino]-4-(4-fluorophenyl)-5-methyl-3-thiophenecarboxylate
CAS 495381-96-9C19H20FNO3S
Ethyl 2-(cyclopropanecarbonylamino)-4-(4-ethylphenyl)-5-methylthiophene-3-carboxylate chemical structure, C20H23NO3S, CAS 445021-86-3
Ethyl 2-(cyclopropanecarbonylamino)-4-(4-ethylphenyl)-5-methylthiophene-3-carboxylate
CAS 445021-86-3C20H23NO3S
Ethyl 2-(cyclopropanecarbonylamino)-4-(3-nitrophenyl)thiophene-3-carboxylate chemical structure, C17H16N2O5S, CAS 773864-75-8
Ethyl 2-(cyclopropanecarbonylamino)-4-(3-nitrophenyl)thiophene-3-carboxylate
CAS 773864-75-8C17H16N2O5S
Ethyl 4-(4-bromophenyl)-2-(cyclopropanecarboxamido)thiophene-3-carboxylate chemical structure, C17H16BrNO3S, CAS 312528-52-2
Ethyl 4-(4-bromophenyl)-2-(cyclopropanecarboxamido)thiophene-3-carboxylate
CAS 312528-52-2C17H16BrNO3S
2-Cyclopropaneamido-4-phenylthiophene-3-carboxylic acid chemical structure, C15H13NO3S, CAS 744230-61-3
2-Cyclopropaneamido-4-phenylthiophene-3-carboxylic acid
CAS 744230-61-3C15H13NO3S
Ethyl 2-[(2,2-dibromo-1-methylcyclopropanecarbonyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate chemical structure, C19H19Br2NO3S, CAS 350997-85-2
Ethyl 2-[(2,2-dibromo-1-methylcyclopropanecarbonyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate
CAS 350997-85-2C19H19Br2NO3S
Methyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4-(4-methoxyphenyl)thiophene-3-carboxylate chemical structure, C18H17Cl2NO4S, CAS 444937-40-0
Methyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4-(4-methoxyphenyl)thiophene-3-carboxylate
CAS 444937-40-0C18H17Cl2NO4S
4-(4-tert-Butylphenyl)-2-[(2,2-dibromo-1-methylcyclopropanecarbonyl)amino]-5-methylthiophene-3-carboxamide chemical structure, C21H24Br2N2O2S, CAS 444936-02-1
4-(4-tert-Butylphenyl)-2-[(2,2-dibromo-1-methylcyclopropanecarbonyl)amino]-5-methylthiophene-3-carboxamide
CAS 444936-02-1C21H24Br2N2O2S
4-(4-tert-Butylphenyl)-2-(cyclopropanecarbonylamino)-5-methylthiophene-3-carboxamide chemical structure, C20H24N2O2S, CAS 496017-93-7
4-(4-tert-Butylphenyl)-2-(cyclopropanecarbonylamino)-5-methylthiophene-3-carboxamide
CAS 496017-93-7C20H24N2O2S
Ethyl 2-{[(2,2-dibromo-1-methylcyclopropyl)carbonyl]amino}-4-(4-fluorophenyl)-5-methyl-3-thiophenecarboxylate chemical structure, C19H18Br2FNO3S, CAS 444937-97-7
Ethyl 2-{[(2,2-dibromo-1-methylcyclopropyl)carbonyl]amino}-4-(4-fluorophenyl)-5-methyl-3-thiophenecarboxylate
CAS 444937-97-7C19H18Br2FNO3S
Methyl 2-(cyclopropanecarbonylamino)-4-(4-fluorophenyl)-5-methylthiophene-3-carboxylate chemical structure, C17H16FNO3S, CAS 496016-75-2
Methyl 2-(cyclopropanecarbonylamino)-4-(4-fluorophenyl)-5-methylthiophene-3-carboxylate
CAS 496016-75-2C17H16FNO3S
Propyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4-phenylthiophene-3-carboxylate chemical structure, C19H19Cl2NO3S, CAS 444936-33-8
Propyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4-phenylthiophene-3-carboxylate
CAS 444936-33-8C19H19Cl2NO3S
Isopropyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4-(4-propylphenyl)-3-thiophenecarboxylate chemical structure, C22H25Cl2NO3S, CAS 445028-52-4
Isopropyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4-(4-propylphenyl)-3-thiophenecarboxylate
CAS 445028-52-4C22H25Cl2NO3S
4-(4-Butylphenyl)-2-[(2-methylcyclopropanecarbonyl)amino]thiophene-3-carboxamide chemical structure, C20H24N2O2S, CAS 492431-54-6
4-(4-Butylphenyl)-2-[(2-methylcyclopropanecarbonyl)amino]thiophene-3-carboxamide
CAS 492431-54-6C20H24N2O2S
Methyl 4-(4-chlorophenyl)-2-(cyclopropanecarbonylamino)-5-methylthiophene-3-carboxylate chemical structure, C17H16ClNO3S, CAS 444925-68-2
Methyl 4-(4-chlorophenyl)-2-(cyclopropanecarbonylamino)-5-methylthiophene-3-carboxylate
CAS 444925-68-2C17H16ClNO3S
Isopropyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4-(4-ethoxyphenyl)-3-thiophenecarboxylate chemical structure, C21H23Cl2NO4S, CAS 445017-90-3
Isopropyl 2-{[(2,2-dichloro-1-methylcyclopropyl)carbonyl]amino}-4-(4-ethoxyphenyl)-3-thiophenecarboxylate
CAS 445017-90-3C21H23Cl2NO4S
Propyl 2-[(2,2-dichloro-1-methylcyclopropanecarbonyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate chemical structure, C20H21Cl2NO3S, CAS 445017-15-2
Propyl 2-[(2,2-dichloro-1-methylcyclopropanecarbonyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate
CAS 445017-15-2C20H21Cl2NO3S
Methyl 4-(4-chlorophenyl)-2-[(2,2-dibromo-1-methylcyclopropanecarbonyl)amino]thiophene-3-carboxylate chemical structure, C17H14Br2ClNO3S, CAS 444936-31-6
Methyl 4-(4-chlorophenyl)-2-[(2,2-dibromo-1-methylcyclopropanecarbonyl)amino]thiophene-3-carboxylate
CAS 444936-31-6C17H14Br2ClNO3S
Ethyl 2-[(2,2-dichloro-1-methylcyclopropanecarbonyl)amino]-4-(4-fluorophenyl)thiophene-3-carboxylate chemical structure, C18H16Cl2FNO3S, CAS 590399-86-3
Ethyl 2-[(2,2-dichloro-1-methylcyclopropanecarbonyl)amino]-4-(4-fluorophenyl)thiophene-3-carboxylate
CAS 590399-86-3C18H16Cl2FNO3S
Ethyl 2-[(2,2-dichloro-1-methylcyclopropanecarbonyl)amino]-4-(4-methoxyphenyl)thiophene-3-carboxylate chemical structure, C19H19Cl2NO4S, CAS 445015-60-1
Ethyl 2-[(2,2-dichloro-1-methylcyclopropanecarbonyl)amino]-4-(4-methoxyphenyl)thiophene-3-carboxylate
CAS 445015-60-1C19H19Cl2NO4S