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Murcko scaffold

Ring system with 3 rings and 18 atoms

7 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
7
With full pages
2
Scaffold SMILES

O=C(NC1CC1)C1CC(=O)N(c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CC1)C1CC(=O)N(c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

N-Cyclopropyl-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C15H18N2O2, CAS 339987-57-4
N-Cyclopropyl-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 339987-57-4C15H18N2O2
1-(4-Chlorophenyl)-N-cyclopropyl-5-oxopyrrolidine-3-carboxamide chemical structure, C14H15ClN2O2, CAS 331758-65-7
1-(4-Chlorophenyl)-N-cyclopropyl-5-oxopyrrolidine-3-carboxamide
CAS 331758-65-7C14H15ClN2O2
1-(3-Chloro-4-methylphenyl)-N-cyclopropyl-5-oxopyrrolidine-3-carboxamide chemical structure, C15H17ClN2O2, CAS 496940-72-8
1-(3-Chloro-4-methylphenyl)-N-cyclopropyl-5-oxopyrrolidine-3-carboxamide
CAS 496940-72-8C15H17ClN2O2
N-Cyclopropyl-1-[4-(dimethylsulfamoyl)phenyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C16H21N3O4S, CAS 1190279-61-8
N-Cyclopropyl-1-[4-(dimethylsulfamoyl)phenyl]-5-oxopyrrolidine-3-carboxamide
CAS 1190279-61-8C16H21N3O4S
N-(Cyanomethyl)-N-cyclopropyl-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C16H17N3O2, CAS 1252355-95-5
N-(Cyanomethyl)-N-cyclopropyl-5-oxo-1-phenylpyrrolidine-3-carboxamide
CAS 1252355-95-5C16H17N3O2
N-(Cyanomethyl)-N-cyclopropyl-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C17H19N3O3, CAS 1252184-69-2
N-(Cyanomethyl)-N-cyclopropyl-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 1252184-69-2C17H19N3O3
N-(Cyanomethyl)-N-cyclopropyl-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C17H19N3O2, CAS 1355874-10-0
N-(Cyanomethyl)-N-cyclopropyl-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 1355874-10-0C17H19N3O2