Murcko scaffold
5,6,7,8-Tetrahydroimidazo(1,2-a)pyrazine scaffold
321 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 9
- Chemicals
- 321
- With full pages
- 25
Scaffold SMILES
c1cn2c(n1)CNCC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 321 chemicals
![3-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-6-carboxylic acid chemical structure, C8H11N3O2, CAS 144888-66-4](/s/BQMKBRYZJVQASX-UHFFFAOYSA-N.svg)
3-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-6-carboxylic acid
CAS 144888-66-4C8H11N3O2
![Ethyl 7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate chemical structure, C10H15N3O2, CAS 623564-19-2](/s/DEQZHPHBXYMRRM-UHFFFAOYSA-N.svg)
Ethyl 7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate
CAS 623564-19-2C10H15N3O2
![Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate hydrochloride chemical structure, C9H14ClN3O2, CAS 623906-17-2](/s/QXVVXFZKXXPMCZ-UHFFFAOYSA-N.svg)
Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate hydrochloride
CAS 623906-17-2C9H14ClN3O2
![Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate chemical structure, C9H13N3O2, CAS 91476-82-3](/s/YTYJZXFCWYHVPG-UHFFFAOYSA-N.svg)
Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate
CAS 91476-82-3C9H13N3O2
![7-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carbaldehyde chemical structure, C8H11N3O, CAS 623564-20-5](/s/IMLXOMJBYPJJOI-UHFFFAOYSA-N.svg)
7-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carbaldehyde
CAS 623564-20-5C8H11N3O
5,6,7,8-Tetrahydroimidazo(1,2-a)pyrazine
CAS 91476-80-1C6H9N3
![Methyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate chemical structure, C8H11N3O2, CAS 91476-81-2](/s/AHIJWXPZLFMLRH-UHFFFAOYSA-N.svg)
Methyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate
CAS 91476-81-2C8H11N3O2
![8-Methyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine chemical structure, C7H11N3, CAS 91476-83-4](/s/GBJMXTLCRQSOHI-UHFFFAOYSA-N.svg)
8-Methyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine
CAS 91476-83-4C7H11N3
![7-Nitroso-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine chemical structure, C6H8N4O, CAS 91476-88-9](/s/SDQPBIDYLCHJKC-UHFFFAOYSA-N.svg)
7-Nitroso-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine
CAS 91476-88-9C6H8N4O
![5,6,7,8-Tetrahydro-8-methyl-7-nitrosoimidazo[1,2-a]pyrazine chemical structure, C7H10N4O, CAS 91476-89-0](/s/KZPVIZBURNZZNR-UHFFFAOYSA-N.svg)
5,6,7,8-Tetrahydro-8-methyl-7-nitrosoimidazo[1,2-a]pyrazine
CAS 91476-89-0C7H10N4O
![Methyl 5,6,7,8-tetrahydro-7-nitroimidazo[1,2-a]pyrazine-2-carboxylate chemical structure, C8H10N4O4, CAS 91476-84-5](/s/ZCWLZBSACMGHOP-UHFFFAOYSA-N.svg)
Methyl 5,6,7,8-tetrahydro-7-nitroimidazo[1,2-a]pyrazine-2-carboxylate
CAS 91476-84-5C8H10N4O4
![Ethyl 5,6,7,8-tetrahydro-7-nitroimidazo[1,2-a]pyrazine-2-carboxylate chemical structure, C9H12N4O4, CAS 91476-85-6](/s/DYQMUQAFEUTTKG-UHFFFAOYSA-N.svg)
Ethyl 5,6,7,8-tetrahydro-7-nitroimidazo[1,2-a]pyrazine-2-carboxylate
CAS 91476-85-6C9H12N4O4
![5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine-2-carbohydrazide chemical structure, C7H11N5O, CAS 119448-34-9](/s/ZIABZKLUJCKCPR-UHFFFAOYSA-N.svg)
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine-2-carbohydrazide
CAS 119448-34-9C7H11N5O
2-Methyl-5H,6H,7H,8H-imidazo(1,2-a)pyrazine
CAS 126052-22-0C7H11N3
![2-(Methoxymethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine chemical structure, C8H13N3O, CAS 126052-30-0](/s/UBFDZMKHGNDAJY-UHFFFAOYSA-N.svg)
2-(Methoxymethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
CAS 126052-30-0C8H13N3O
![3-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine chemical structure, C7H11N3, CAS 126052-23-1](/s/JTXJNDWSZKWBTO-UHFFFAOYSA-N.svg)
3-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
CAS 126052-23-1C7H11N3
![2-(Trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine chemical structure, C7H8F3N3, CAS 126069-70-3](/s/RHYZIHOBSWRZDL-UHFFFAOYSA-N.svg)
2-(Trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine
CAS 126069-70-3C7H8F3N3
![2-Ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine chemical structure, C8H13N3, CAS 126052-32-2](/s/WJPFFUFOYZQXKC-UHFFFAOYSA-N.svg)
2-Ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
CAS 126052-32-2C8H13N3
![2-Isopropyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine chemical structure, C9H15N3, CAS 126052-25-3](/s/FSWUBMHGSRAQIY-UHFFFAOYSA-N.svg)
2-Isopropyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
CAS 126052-25-3C9H15N3
![3-Ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine chemical structure, C8H13N3, CAS 126052-27-5](/s/OJRQOUISBFIEPN-UHFFFAOYSA-N.svg)
3-Ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
CAS 126052-27-5C8H13N3
![Ethyl 3-chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate chemical structure, C9H12ClN3O2, CAS 903130-23-4](/s/FSPLEMJWDPSQPC-UHFFFAOYSA-N.svg)
Ethyl 3-chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate
CAS 903130-23-4C9H12ClN3O2
![7-(tert-Butoxycarbonyl)-3-chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid chemical structure, C12H16ClN3O4, CAS 903130-30-3](/s/DKAJUVQRVUHWJW-UHFFFAOYSA-N.svg)
7-(tert-Butoxycarbonyl)-3-chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid
CAS 903130-30-3C12H16ClN3O4
![Ethyl 5,6,7,8-tetrahydroimidazo[1,2-A]pyrazine-2-carboxylate dihydrochloride hemihydrate chemical structure, C9H17Cl2N3O3, CAS 892502-00-0](/s/FVACSCIVHHZRPL-UHFFFAOYSA-N.svg)
Ethyl 5,6,7,8-tetrahydroimidazo[1,2-A]pyrazine-2-carboxylate dihydrochloride hemihydrate
CAS 892502-00-0C9H17Cl2N3O3
![7-Methyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine chemical structure, C7H11N3, CAS 1341038-09-2](/s/CFAPHOLBVIDQAZ-UHFFFAOYSA-N.svg)
7-Methyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine
CAS 1341038-09-2C7H11N3
- 7-Acetyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine-2-carboxylic acid1554305-21-3C9H11N3O3
- 7-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid1101864-54-3C8H11N3O2
- 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid885281-33-4C7H9N3O2
- tert-Butyl 5,6-dihydroimidazo(1,2-a)pyrazine-7(8H)-carboxylate345311-03-7C11H17N3O2
- Ethyl 5H,6H,7H,8H-imidazo[1,2-a]pyrazine-2-carboxylate dihydrochloride623564-18-1C9H15Cl2N3O2
- 3-Bromo-7-((tert-butoxy)carbonyl)-5H,6H,7H,8H-imidazo(1,2-a)pyrazine-2-carboxylic acid1000576-71-5C12H16BrN3O4
- Ethyl 3-bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate1170776-06-3C9H12BrN3O2
- 1 suppliers7-tert-Butyl 2-ethyl 3-bromo-5,6-dihydroimidazo[1,2-A]pyrazine-2,7(8H)-dicarboxylate1000576-75-9C14H20BrN3O4
- 3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine954239-19-1C6H8BrN3
- tert-Butyl 3-bromo-5H,6H,7H,8H-imidazo(1,2-a)pyrazine-7-carboxylate949922-61-6C11H16BrN3O2
- 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine dihydrochloride735266-95-2C6H11Cl2N3
- Ethyl 3-bromo-5H,6H,7H,8H-imidazo(1,2-a)pyrazine-2-carboxylate hydrochloride1170568-70-3C9H13BrClN3O2
- 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine hydrochloride1187830-84-7C6H10ClN3
- 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride911064-58-9C7H9ClF3N3
- 3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride1187830-45-0C6H9BrClN3
- 7-(1,1-Dimethylethyl) 5,6-dihydroimidazo(1,2-a)pyrazine-2,7(8H)-dicarboxylate885281-30-1C12H17N3O4
- N,N-Dimethyl-1-(5,6,7,8-tetrahydroimidazo[1,2-A]pyrazin-2-yl)methanamine158785-58-1C9H16N4
- 8-Methyl-2-(trifluoromethyl)-5H,6H,7H,8H-imidazo(1,2-a)pyrazine611240-70-1C8H10F3N3
- Methyl 3-bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate1211011-30-1C8H10BrN3O2
- 2-(Trifluoromethyl)-3-vinyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine1269293-99-3C9H10F3N3
- 5,6-Dihydro-8H-imidazo[1,2-A]pyrazin-7-ylamine1203305-56-9C6H10N4
- 2,3-Dimethyl-5H,6H,7H,8H-imidazo(1,2-a)pyrazine1250515-54-8C8H13N3
- 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-A]pyrazine-2,7(8H)-dicarboxylate1053656-22-6C14H21N3O4
- Ethyl 3-chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate hydrochloride1174069-17-0C9H13Cl2N3O2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold c1ccc2[nH]ccc2c1](/scaffold/SIKJAQJRHWYJAI-UHFFFAOYSA-N/structure.svg)
c1ccc2[nH]ccc2c12,455 chemicals![Scaffold c1ccc2[nH]cnc2c1](/scaffold/HYZJCKYKOHLVJF-UHFFFAOYSA-N/structure.svg)
c1ccc2[nH]cnc2c11,206 chemicals![Scaffold c1ccc2[nH]ncc2c1](/scaffold/BAXOFTOLAUCFNW-UHFFFAOYSA-N/structure.svg)
c1ccc2[nH]ncc2c1795 chemicals
c1ccc2scnc2c1756 chemicals
c1ccc2occc2c1632 chemicals
c1ccc2c(c1)CCC2621 chemicals
c1ccc2c(c1)OCO2536 chemicals
c1ccc2sccc2c1529 chemicals
c1ccn2ccnc2c1525 chemicals
c1ccc2c(c1)CCN2440 chemicals![Scaffold O=c1[nH]c(=O)c2[nH]cnc2[nH]1](/scaffold/LRFVTYWOQMYALW-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2[nH]cnc2[nH]1411 chemicals
O=C1NC(=O)c2ccccc21352 chemicals