Murcko scaffold
Ring system with 2 rings and 18 atoms
44 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 18
- Chemicals
- 44
- With full pages
- 13
Scaffold SMILES
O=C(NN=Cc1ccccc1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 44 of 44 chemicals
![1-[1-(2-Hydroxyphenyl)ethylideneamino]-3-phenylurea chemical structure, C15H15N3O2](/s/RYXOJUSBPPXAGH-UHFFFAOYSA-N.svg)
1-[1-(2-Hydroxyphenyl)ethylideneamino]-3-phenylurea
C15H15N3O2
![2-[(2-Chloro-6-fluorophenyl)methylene]-N-(2-methylphenyl)hydrazinecarboxamide chemical structure, C15H13ClFN3O, CAS 861241-19-2](/s/LJLUUZCLJUJIEO-UHFFFAOYSA-N.svg)
2-[(2-Chloro-6-fluorophenyl)methylene]-N-(2-methylphenyl)hydrazinecarboxamide
CAS 861241-19-2C15H13ClFN3O
![2-[1-(2,4-Dihydroxyphenyl)ethylidene]-N-phenylhydrazinecarboxamide chemical structure, C15H15N3O3, CAS 316142-73-1](/s/ALGGLWYXQVJIIF-UHFFFAOYSA-N.svg)
2-[1-(2,4-Dihydroxyphenyl)ethylidene]-N-phenylhydrazinecarboxamide
CAS 316142-73-1C15H15N3O3
![N-[2-Chloro-4-(trifluoromethyl)phenyl]-2-[[4-(trifluoromethyl)phenyl]methylene]hydrazinecarboxamide chemical structure, C16H10ClF6N3O, CAS 259545-12-5](/s/YRPRFCQALTUNNF-UHFFFAOYSA-N.svg)
N-[2-Chloro-4-(trifluoromethyl)phenyl]-2-[[4-(trifluoromethyl)phenyl]methylene]hydrazinecarboxamide
CAS 259545-12-5C16H10ClF6N3O
![2-{[3,5-Di(tert-butyl)-4-hydroxyphenyl]methylene}-N-phenyl-1-hydrazinecarboxamide chemical structure, C22H29N3O2](/s/UNJDNVXDOXCXCM-UHFFFAOYSA-N.svg)
2-{[3,5-Di(tert-butyl)-4-hydroxyphenyl]methylene}-N-phenyl-1-hydrazinecarboxamide
C22H29N3O2
![1-[(E)-(2,3-Dichlorophenyl)methylideneamino]-3-phenylurea chemical structure, C14H11Cl2N3O, CAS 303772-11-4](/s/LUSVDTGEASQYGO-RQZCQDPDSA-N.svg)
1-[(E)-(2,3-Dichlorophenyl)methylideneamino]-3-phenylurea
CAS 303772-11-4C14H11Cl2N3O
![2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide chemical structure, C16H16BrN3O, CAS 415687-81-9](/s/QVNLLEFLGISSAQ-VCHYOVAHSA-N.svg)
2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide
CAS 415687-81-9C16H16BrN3O
3-Methylbenzaldehyde N-phenylsemicarbazone
CAS 303772-20-5C15H15N3O
![1-[(E)-(2-Methylphenyl)methylideneamino]-3-phenylurea chemical structure, C15H15N3O, CAS 303772-00-1](/s/GDCFEWUQBYJDDQ-LFIBNONCSA-N.svg)
1-[(E)-(2-Methylphenyl)methylideneamino]-3-phenylurea
CAS 303772-00-1C15H15N3O
![1-[(E)-(2-Ethoxyphenyl)methylideneamino]-3-phenylurea chemical structure, C16H17N3O2, CAS 303759-85-5](/s/VRHDCUJOZMFTBL-SFQUDFHCSA-N.svg)
1-[(E)-(2-Ethoxyphenyl)methylideneamino]-3-phenylurea
CAS 303759-85-5C16H17N3O2
![1-[(E)-1-(4-Bromophenyl)ethylideneamino]-3-phenylurea chemical structure, C15H14BrN3O, CAS 303212-92-2](/s/WRWOAKWVTDBVKM-WOJGMQOQSA-N.svg)
1-[(E)-1-(4-Bromophenyl)ethylideneamino]-3-phenylurea
CAS 303212-92-2C15H14BrN3O
![1-[(E)-(2-Bromophenyl)methylideneamino]-3-phenylurea chemical structure, C14H12BrN3O, CAS 6262-59-5](/s/OPTLOMNGKVJNGN-MHWRWJLKSA-N.svg)
1-[(E)-(2-Bromophenyl)methylideneamino]-3-phenylurea
CAS 6262-59-5C14H12BrN3O
2,4-Dichlorobenzaldehyde N-phenylsemicarbazone
CAS 33814-98-1C14H11Cl2N3O
2-Methyl-1-phenyl-1-propanone N-phenylsemicarbazone
CAS 316131-52-9C17H19N3O
1-(4-Methylphenyl)ethanone N-phenylsemicarbazone
CAS 22454-60-0C16H17N3O
![1-[(E)-(4-Nitrophenyl)methylideneamino]-3-phenylurea chemical structure, C14H12N4O3, CAS 100621-27-0](/s/BZJITMQJXFAJGL-XNTDXEJSSA-N.svg)
1-[(E)-(4-Nitrophenyl)methylideneamino]-3-phenylurea
CAS 100621-27-0C14H12N4O3
![1-[(E)-(3,4-Dimethoxyphenyl)methylideneamino]-3-phenylurea chemical structure, C16H17N3O3, CAS 198134-59-7](/s/YGXDPUBMVLBQID-GZTJUZNOSA-N.svg)
1-[(E)-(3,4-Dimethoxyphenyl)methylideneamino]-3-phenylurea
CAS 198134-59-7C16H17N3O3
4-Chlorobenzaldehyde N-phenylsemicarbazone
CAS 93535-29-6C14H12ClN3O
![1-[(E)-(4-Methylsulfanylphenyl)methylideneamino]-3-phenylurea chemical structure, C15H15N3OS, CAS 219996-93-7](/s/UKMOKIRUIASGTB-LFIBNONCSA-N.svg)
1-[(E)-(4-Methylsulfanylphenyl)methylideneamino]-3-phenylurea
CAS 219996-93-7C15H15N3OS
4-(Dimethylamino)benzaldehyde N-phenylsemicarbazone
CAS 199791-23-6C16H18N4O
3-Hydroxy-4-methoxybenzaldehyde N-phenylsemicarbazone
CAS 302909-67-7C15H15N3O3
![1-[(E)-Benzylideneamino]-3-phenyl-urea chemical structure, C14H13N3O, CAS 1006894-80-9](/s/SXCIVFODNMDTER-RVDMUPIBSA-N.svg)
1-[(E)-Benzylideneamino]-3-phenyl-urea
CAS 1006894-80-9C14H13N3O
1-Phenylethanone N-phenylsemicarbazone
CAS 174790-62-6C15H15N3O
3-Bromo-5-hydroxy-4-methoxybenzaldehyde N-phenylsemicarbazone
CAS 303083-02-5C15H14BrN3O3
- (E)-N-Phenyl-2-(2-(prop-2-yn-1-yloxy)benzylidene)hydrazinecarboxamide853890-95-6C17H15N3O2
- Propiophenone, 3-(diethylamino)-, 4-(p-methoxyphenyl)semicarbazone, hydrochloride97669-57-3C21H29ClN4O2
- Propiophenone, 3-(dimethylamino)-, 4-(p-methoxyphenyl)semicarbazone, hydrochloride97669-69-7C19H25ClN4O2
- 2-Benzylidene-N-(2,4-dimethylphenyl)hydrazine-1-carboxamide478037-99-9C16H17N3O
- 2-Benzylidene-N-(2,5-dimethylphenyl)hydrazine-1-carboxamide918824-19-8C16H17N3O
- 2-[[4-(Dimethylamino)phenyl]methylene]-N-(2,6-dimethylphenyl)hydrazinecarboxamide868662-83-3C18H22N4O
- 2-Hydroxybenzaldehyde N-phenylsemicarbazone91991-03-6C14H13N3O2
- 3,5-Dichloro-2-hydroxybenzaldehyde N-phenylsemicarbazone1713-71-9C14H11Cl2N3O2
- 1-[[(Z)-(5-Hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-3-phenylurea5268-02-0C14H13N3O3
- (2E)-2-(3,4-Dihydroxybenzylidene)-N-phenylhydrazinecarboxamide304456-23-3C14H13N3O3
- 1-[(E)-(5-Chloro-2-hydroxyphenyl)methylideneamino]-3-phenylurea1713-70-8C14H12ClN3O2
- (2E)-2-[1-(2-Hydroxyphenyl)ethylidene]-N-phenylhydrazinecarboxamide293326-02-0C15H15N3O2
- (2E)-2-[1-(4-Hydroxyphenyl)ethylidene]-N-phenylhydrazinecarboxamide316136-60-4C15H15N3O2
- 4-Hydroxy-3-methoxybenzaldehyde N-phenylsemicarbazone303063-78-7C15H15N3O3
- 3-Bromo-4-hydroxy-5-methoxybenzaldehyde N-phenylsemicarbazone303083-10-5C15H14BrN3O3
- 1-[(E)-(3,5-Ditert-butyl-4-hydroxyphenyl)methylideneamino]-3-phenylureaC22H29N3O2
- 3-[(Z)-[(3,5-di-tert-Butyl-4-hydroxyphenyl)methylidene]amino]-1-phenylurea339016-25-0C22H29N3O2
- Faah/magl-IN-22765077-82-3C15H13Cl2N3O3S
- 2-[4-({2-[(2,3-Dimethylphenyl)carbamoyl]hydrazinylidene}methyl)phenoxy]propanoic acid886771-04-6C19H21N3O4
- N-(2-Chlorophenyl)-2-[(4-chlorophenyl)methylene]hydrazinecarboxamide33814-97-0C14H11Cl2N3O
Related scaffolds
Same ring framework with different atoms or bond orders
S=C(NN=Cc1ccccc1)Nc1ccccc1105 chemicals
S=C(NCCc1ccccc1)Nc1ccccc160 chemicals
c1ccc(CCNCCc2ccccc2)cc158 chemicals
O=C(COc1ccccc1)NCc1ccccc146 chemicals
O=C(NCCOc1ccccc1)c1ccccc146 chemicals
O=C(C=Cc1ccccc1)NCc1ccccc143 chemicals
c1ccc(OCCCOc2ccccc2)cc141 chemicals
O=C(CC(=O)Nc1ccccc1)Nc1ccccc137 chemicals
O=C(CNS(=O)(=O)c1ccccc1)Nc1ccccc136 chemicals
O=C(CSCc1ccccc1)Nc1ccccc133 chemicals
O=C(Cc1ccccc1)NCCc1ccccc132 chemicals
O=C(CNCc1ccccc1)Nc1ccccc131 chemicals