Murcko scaffold
Ring system with 2 rings and 20 atoms
335 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 20
- Chemicals
- 335
- With full pages
- 36
Scaffold SMILES
O=C(CNS(=O)(=O)c1ccccc1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 335 chemicals
N(alpha)-Tosylarginine-4-nitroanilide
CAS 36186-55-7C19H24N6O5S
N-(2,4-Dimethylphenyl)-2-(N,4-dimethylphenylsulfonamido)acetamide
CAS 428505-36-6C18H22N2O3S
2-(N,4-dimethylphenylsulfonamido)-N-(m-tolyl)acetamide
CAS 428822-72-4C17H20N2O3S
![N-(3-Methoxyphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C17H20N2O4S, CAS 428833-64-1](/s/PXYOEXDDYMWBKO-UHFFFAOYSA-N.svg)
N-(3-Methoxyphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428833-64-1C17H20N2O4S
![N-(2-Methoxyphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C17H20N2O4S, CAS 428840-41-9](/s/YHZGMFKPQHQRBO-UHFFFAOYSA-N.svg)
N-(2-Methoxyphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428840-41-9C17H20N2O4S
![N-(4-Fluorophenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C16H17FN2O3S, CAS 428838-08-8](/s/GRVGEHDLMDXHJG-UHFFFAOYSA-N.svg)
N-(4-Fluorophenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428838-08-8C16H17FN2O3S
![N-(4-Methoxyphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C17H20N2O4S, CAS 428843-16-7](/s/NMQDRASTLJBEPB-UHFFFAOYSA-N.svg)
N-(4-Methoxyphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428843-16-7C17H20N2O4S
![2-[Methyl-(4-methylphenyl)sulfonylamino]-N-(2-methylphenyl)acetamide chemical structure, C17H20N2O3S, CAS 428844-61-5](/s/ZHICMESPHBPVFK-UHFFFAOYSA-N.svg)
2-[Methyl-(4-methylphenyl)sulfonylamino]-N-(2-methylphenyl)acetamide
CAS 428844-61-5C17H20N2O3S
![N-(2,5-Dimethylphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C18H22N2O3S, CAS 428846-62-2](/s/GUAWWNGDYYYEBW-UHFFFAOYSA-N.svg)
N-(2,5-Dimethylphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428846-62-2C18H22N2O3S
![N-(3,4-Dimethylphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C18H22N2O3S, CAS 428847-65-8](/s/DOZJSVQLPZMUSB-UHFFFAOYSA-N.svg)
N-(3,4-Dimethylphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428847-65-8C18H22N2O3S
![2-[Methyl-(4-methylphenyl)sulfonylamino]-N-(4-methylphenyl)acetamide chemical structure, C17H20N2O3S, CAS 757218-04-5](/s/BMXXERCMRKJCFS-UHFFFAOYSA-N.svg)
2-[Methyl-(4-methylphenyl)sulfonylamino]-N-(4-methylphenyl)acetamide
CAS 757218-04-5C17H20N2O3S
![N-(2-Fluorophenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C16H17FN2O3S, CAS 428851-45-0](/s/BIPGYNYQOMZCDI-UHFFFAOYSA-N.svg)
N-(2-Fluorophenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428851-45-0C16H17FN2O3S
![N-(2-Ethylphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C18H22N2O3S, CAS 501914-70-1](/s/MTLLZJATSXFJCT-UHFFFAOYSA-N.svg)
N-(2-Ethylphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 501914-70-1C18H22N2O3S
![2-[Benzenesulfonyl(methyl)amino]-N-(4-chlorophenyl)acetamide chemical structure, C15H15ClN2O3S, CAS 593262-28-3](/s/JEFUJOVQISUVGF-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-(4-chlorophenyl)acetamide
CAS 593262-28-3C15H15ClN2O3S
![2-[Benzenesulfonyl(methyl)amino]-N-(4-propan-2-ylphenyl)acetamide chemical structure, C18H22N2O3S, CAS 593262-25-0](/s/KJLMATWBJNIDBT-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-(4-propan-2-ylphenyl)acetamide
CAS 593262-25-0C18H22N2O3S
![2-[Benzenesulfonyl(methyl)amino]-N-(2,5-dimethylphenyl)acetamide chemical structure, C17H20N2O3S, CAS 593262-24-9](/s/AETUHKOKVUAZOM-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-(2,5-dimethylphenyl)acetamide
CAS 593262-24-9C17H20N2O3S
![2-[Benzenesulfonyl(methyl)amino]-N-phenylacetamide chemical structure, C15H16N2O3S, CAS 445227-00-9](/s/DKZMXZZDXQRWOJ-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-phenylacetamide
CAS 445227-00-9C15H16N2O3S
![2-[Benzenesulfonyl(methyl)amino]-N-(2-fluorophenyl)acetamide chemical structure, C15H15FN2O3S, CAS 593262-27-2](/s/WEURNNJZEZEFMC-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-(2-fluorophenyl)acetamide
CAS 593262-27-2C15H15FN2O3S
![2-[Benzenesulfonyl(methyl)amino]-N-(2-ethyl-6-methylphenyl)acetamide chemical structure, C18H22N2O3S, CAS 692775-88-5](/s/GGOJWVDOCOSENV-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-(2-ethyl-6-methylphenyl)acetamide
CAS 692775-88-5C18H22N2O3S
![2-[Benzenesulfonyl(methyl)amino]-N-(3-nitrophenyl)acetamide chemical structure, C15H15N3O5S, CAS 692776-12-8](/s/YEADLDZAMDKRJI-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-(3-nitrophenyl)acetamide
CAS 692776-12-8C15H15N3O5S
2-(Benzenesulfonamido)-N-(2-methoxy-5-methylphenyl)acetamide
CAS 593263-51-5C16H18N2O4S
![2-[Benzenesulfonyl(methyl)amino]-N-(3-methoxyphenyl)acetamide chemical structure, C16H18N2O4S, CAS 693233-63-5](/s/SGISMBJACORARY-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-(3-methoxyphenyl)acetamide
CAS 693233-63-5C16H18N2O4S
![2-[Benzenesulfonyl(methyl)amino]-N-(4-methoxyphenyl)acetamide chemical structure, C16H18N2O4S, CAS 693237-42-2](/s/KPAOZYBCMBTMGZ-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-(4-methoxyphenyl)acetamide
CAS 693237-42-2C16H18N2O4S
![2-[Benzenesulfonyl(methyl)amino]-N-(2,4-difluorophenyl)acetamide chemical structure, C15H14F2N2O3S, CAS 679826-76-7](/s/LFKSRXNKJOSSDB-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-(2,4-difluorophenyl)acetamide
CAS 679826-76-7C15H14F2N2O3S
- N-(3-Acetylphenyl)-2-[benzenesulfonyl(methyl)amino]acetamide693239-87-1C17H18N2O4S
- 2-(Benzenesulfonamido)-N-(4-ethoxyphenyl)acetamide593263-48-0C16H18N2O4S
- 2-[Benzenesulfonyl(methyl)amino]-N-(2-methoxy-5-methylphenyl)acetamide693241-03-1C17H20N2O4S
- 2-[Benzenesulfonyl(methyl)amino]-N-(3-fluorophenyl)acetamide593262-39-6C15H15FN2O3S
- N-(2,6-Dimethylphenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide862786-36-5C18H22N2O3S
- N-(2-Cyanophenyl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide701238-16-6C17H17N3O3S
- 2-[Benzenesulfonyl(methyl)amino]-N-(2,4,6-trimethylphenyl)acetamide701225-80-1C18H22N2O3S
- N-(4-Fluorophenyl)-2-[[(4-methoxyphenyl)sulfonyl](methyl)amino]acetamide593264-41-6C16H17FN2O4S
- N-(4-Chloro-2-methylphenyl)-2-[(4-methoxyphenyl)sulfonyl-methylamino]acetamide593264-42-7C17H19ClN2O4S
- N-(2,6-Difluorophenyl)-2-[(4-methoxyphenyl)sulfonyl-methylamino]acetamide593264-44-9C16H16F2N2O4S
- 2-[(4-Methoxyphenyl)sulfonyl-methylamino]-N-[3-(trifluoromethyl)phenyl]acetamide593264-45-0C17H17F3N2O4S
- N-(4-Fluorophenyl)-2-[(2,3,5,6-tetramethylphenyl)sulfonylamino]acetamide690246-07-2C18H21FN2O3S
- N-(2-Fluorophenyl)-2-{[(2,3,5,6-tetramethylphenyl)sulfonyl]amino}acetamide690644-44-1C18H21FN2O3S
- N-(3-Chloro-4-fluorophenyl)-2-[(2,3,5,6-tetramethylphenyl)sulfonylamino]acetamide690644-46-3C18H20ClFN2O3S
- N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[(3-methoxyphenyl)sulfonylamino]acetamide690245-95-5C16H14ClF3N2O4S
- N-(4-tert-Butylphenyl)-2-(3-methoxybenzenesulfonamido)acetamide690245-94-4C19H24N2O4S
- 2-(((4-Bromophenyl)sulfonyl)(2-hydroxyethyl)amino)-N-(4-fluorophenyl)acetamide256521-73-0C16H16BrFN2O4S
- 2-[(4-Bromophenyl)sulfonyl-methylamino]-N-(2-ethylphenyl)acetamide499113-37-0C17H19BrN2O3S
- 2-[(4-Chlorophenyl)sulfonyl-methylamino]-N-(2,4,5-trichlorophenyl)acetamide499113-55-2C15H12Cl4N2O3S
- 2-[Methyl-(4-methylphenyl)sulfonylamino]-N-(2-methylsulfanylphenyl)acetamide675864-19-4C17H20N2O3S2
- 2-[[2-[Methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]benzamide702647-65-2C17H19N3O4S
- N-(3-Chloro-2-methylphenyl)-2-[(4-methoxy-3-methylphenyl)sulfonyl-methylamino]acetamide708282-64-8C18H21ClN2O4S
- 4-({N-[(4-Methoxy-3-methylphenyl)sulfonyl]-N-methylglycyl}amino)benzamide708991-56-4C18H21N3O5S
- N-(2,6-Diethylphenyl)-2-[(4-methoxy-3-methylphenyl)sulfonyl-methylamino]acetamide708250-50-4C21H28N2O4S
Related scaffolds
Same ring framework with different atoms or bond orders
S=C(NN=Cc1ccccc1)Nc1ccccc1105 chemicals
S=C(NCCc1ccccc1)Nc1ccccc160 chemicals
c1ccc(CCNCCc2ccccc2)cc158 chemicals
O=C(COc1ccccc1)NCc1ccccc146 chemicals
O=C(NCCOc1ccccc1)c1ccccc146 chemicals
O=C(C=Cc1ccccc1)NCc1ccccc143 chemicals
c1ccc(OCCCOc2ccccc2)cc141 chemicals
O=C(CC(=O)Nc1ccccc1)Nc1ccccc137 chemicals
O=C(CSCc1ccccc1)Nc1ccccc133 chemicals
O=C(Cc1ccccc1)NCCc1ccccc132 chemicals
O=C(CNCc1ccccc1)Nc1ccccc131 chemicals
O=C(C=Cc1ccccc1)C=Cc1ccccc131 chemicals