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Murcko scaffold

Ring system with 2 rings and 18 atoms

224 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
18
Chemicals
224
With full pages
43
Scaffold SMILES

O=C(C=Cc1ccccc1)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 224 chemicals

N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide chemical structure, C17H14N2O3, CAS 134036-52-5
N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
CAS 134036-52-5C17H14N2O3
(2E)-N-Benzyl-3-(4-methoxyphenyl)prop-2-enamide chemical structure, C17H17NO2, CAS 612095-65-5
(2E)-N-Benzyl-3-(4-methoxyphenyl)prop-2-enamide
CAS 612095-65-5C17H17NO2
N-(4-Chloro-benzyl)-3-(4-ethoxy-phenyl)-acrylamide chemical structure, C18H18ClNO2, CAS 297149-87-2
N-(4-Chloro-benzyl)-3-(4-ethoxy-phenyl)-acrylamide
CAS 297149-87-2C18H18ClNO2
3-(4-Ethoxyphenyl)-N-(4-fluorobenzyl)acrylamide chemical structure, C18H18FNO2, CAS 297149-92-9
3-(4-Ethoxyphenyl)-N-(4-fluorobenzyl)acrylamide
CAS 297149-92-9C18H18FNO2
AG-1801 chemical structure, C17H13N3O3, CAS 204010-55-9
AG-1801
CAS 204010-55-9C17H13N3O3
(E)-N-Benzyl-3-(4-chlorophenyl)acrylamide chemical structure, C16H14ClNO, CAS 1052176-93-8
(E)-N-Benzyl-3-(4-chlorophenyl)acrylamide
CAS 1052176-93-8C16H14ClNO
(2E)-N-Benzyl-2-cyano-3-[4-(diethylamino)phenyl]acrylamide chemical structure, C21H23N3O, CAS 874655-87-5
(2E)-N-Benzyl-2-cyano-3-[4-(diethylamino)phenyl]acrylamide
CAS 874655-87-5C21H23N3O
(2E)-N-Benzyl-3-(3-nitrophenyl)prop-2-enamide chemical structure, C16H14N2O3, CAS 1085449-49-5
(2E)-N-Benzyl-3-(3-nitrophenyl)prop-2-enamide
CAS 1085449-49-5C16H14N2O3
(2E)-N-Benzyl-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide chemical structure, C17H14N2O2, CAS 874655-86-4
(2E)-N-Benzyl-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide
CAS 874655-86-4C17H14N2O2
N-Benzyl-3-(4-cyanophenyl)prop-2-enamide chemical structure, C17H14N2O, CAS 1085449-55-3
N-Benzyl-3-(4-cyanophenyl)prop-2-enamide
CAS 1085449-55-3C17H14N2O
(E)-N-[(4-Chlorophenyl)methyl]-3-(2-methoxyphenyl)prop-2-enamide chemical structure, C17H16ClNO2, CAS 592473-43-3
(E)-N-[(4-Chlorophenyl)methyl]-3-(2-methoxyphenyl)prop-2-enamide
CAS 592473-43-3C17H16ClNO2
(E)-N-Benzyl-3-(3-bromo-4-methoxyphenyl)acrylamide chemical structure, C17H16BrNO2, CAS 302574-36-3
(E)-N-Benzyl-3-(3-bromo-4-methoxyphenyl)acrylamide
CAS 302574-36-3C17H16BrNO2
(2E)-N-Benzyl-3-(4-ethoxy-3-methoxyphenyl)-N-methylprop-2-enamide chemical structure, C20H23NO3, CAS 302807-76-7
(2E)-N-Benzyl-3-(4-ethoxy-3-methoxyphenyl)-N-methylprop-2-enamide
CAS 302807-76-7C20H23NO3
(E)-N-Benzyl-2-cyano-3-(4-methoxyphenyl)prop-2-enamide chemical structure, C18H16N2O2, CAS 874655-85-3
(E)-N-Benzyl-2-cyano-3-(4-methoxyphenyl)prop-2-enamide
CAS 874655-85-3C18H16N2O2
N-Benzyl-3-(2,6-dichlorophenyl)acrylamide chemical structure, C16H13Cl2NO, CAS 1164523-36-7
N-Benzyl-3-(2,6-dichlorophenyl)acrylamide
CAS 1164523-36-7C16H13Cl2NO
(E)-N-Benzyl-3-(2,4-dimethoxyphenyl)acrylamide chemical structure, C18H19NO3, CAS 186261-37-0
(E)-N-Benzyl-3-(2,4-dimethoxyphenyl)acrylamide
CAS 186261-37-0C18H19NO3
(E)-N-[(2-Methoxyphenyl)methyl]-3-phenylprop-2-enamide chemical structure, C17H17NO2, CAS 331440-11-0
(E)-N-[(2-Methoxyphenyl)methyl]-3-phenylprop-2-enamide
CAS 331440-11-0C17H17NO2
(E)-3-(2,6-Dichlorophenyl)-N-[(4-methoxyphenyl)methyl]prop-2-enamide chemical structure, C17H15Cl2NO2, CAS 546077-16-1
(E)-3-(2,6-Dichlorophenyl)-N-[(4-methoxyphenyl)methyl]prop-2-enamide
CAS 546077-16-1C17H15Cl2NO2
3-(4-Bromophenyl)-N-(4-methoxybenzyl)acrylamide chemical structure, C17H16BrNO2, CAS 1426293-89-1
3-(4-Bromophenyl)-N-(4-methoxybenzyl)acrylamide
CAS 1426293-89-1C17H16BrNO2
N-(2-Methoxybenzyl)-3-(4-methoxyphenyl)acrylamide chemical structure, C18H19NO3, CAS 357278-57-0
N-(2-Methoxybenzyl)-3-(4-methoxyphenyl)acrylamide
CAS 357278-57-0C18H19NO3
(2E)-N-(4-Fluorobenzyl)-3-phenylprop-2-enamide chemical structure, C16H14FNO, CAS 1019771-75-5
(2E)-N-(4-Fluorobenzyl)-3-phenylprop-2-enamide
CAS 1019771-75-5C16H14FNO
(E)-N-[(4-Methoxyphenyl)methyl]-3-phenylprop-2-enamide chemical structure, C17H17NO2, CAS 1019771-78-8
(E)-N-[(4-Methoxyphenyl)methyl]-3-phenylprop-2-enamide
CAS 1019771-78-8C17H17NO2
(E)-N-Benzyl-3-phenyl-N-propan-2-ylprop-2-enamide chemical structure, C19H21NO, CAS 349418-48-0
(E)-N-Benzyl-3-phenyl-N-propan-2-ylprop-2-enamide
CAS 349418-48-0C19H21NO
(E)-N-Benzyl-3-(2,4-dichlorophenyl)prop-2-enamide chemical structure, C16H13Cl2NO, CAS 324563-22-6
(E)-N-Benzyl-3-(2,4-dichlorophenyl)prop-2-enamide
CAS 324563-22-6C16H13Cl2NO