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Murcko scaffold

5-(4-Phenoxyphenyl)-N-(4-piperidinylmethyl)-4-pyrimidinamine scaffold

23 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
23
With full pages
1
Scaffold SMILES

c1ccc(Oc2ccc(-c3cncnc3NCC3CCNCC3)cc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5-(4-Phenoxyphenyl)-N-(4-piperidinylmethyl)-4-pyrimidinamine page
Murcko scaffold c1ccc(Oc2ccc(-c3cncnc3NCC3CCNCC3)cc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

tert-Butyl 4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate chemical structure, C27H33N5O3, CAS 1415824-87-1
tert-Butyl 4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate
CAS 1415824-87-1C27H33N5O3
5-(4-Phenoxyphenyl)-N4-(piperidin-4-ylmethyl)pyrimidine-4,6-diamine chemical structure, C22H25N5O, CAS 1415824-88-2
5-(4-Phenoxyphenyl)-N4-(piperidin-4-ylmethyl)pyrimidine-4,6-diamine
CAS 1415824-88-2C22H25N5O
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)propan-1-one chemical structure, C25H29N5O2, CAS 1415824-51-9
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)propan-1-one
CAS 1415824-51-9C25H29N5O2
5-(4-Phenoxyphenyl)-N-(4-piperidinylmethyl)-4-pyrimidinamine chemical structure, C22H24N4O, CAS 1415825-78-3
5-(4-Phenoxyphenyl)-N-(4-piperidinylmethyl)-4-pyrimidinamine
CAS 1415825-78-3C22H24N4O
N4-((1-(methylsulfonyl)piperidin-4-yl)methyl)-5-(4-phenoxyphenyl)pyrimidine-4,6-diamine chemical structure, C23H27N5O3S, CAS 1415821-72-5
N4-((1-(methylsulfonyl)piperidin-4-yl)methyl)-5-(4-phenoxyphenyl)pyrimidine-4,6-diamine
CAS 1415821-72-5C23H27N5O3S
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)ethanone chemical structure, C24H27N5O2, CAS 1415821-41-8
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)ethanone
CAS 1415821-41-8C24H27N5O2
5-(4-Phenoxyphenyl)-N4-((1-(vinylsulfonyl)piperidin-4-yl)methyl)pyrimidine-4,6-diamine chemical structure, C24H27N5O3S, CAS 1415821-28-1
5-(4-Phenoxyphenyl)-N4-((1-(vinylsulfonyl)piperidin-4-yl)methyl)pyrimidine-4,6-diamine
CAS 1415821-28-1C24H27N5O3S
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-4-hydroxypiperidin-1-yl)prop-2-en-1-one chemical structure, C25H27N5O3, CAS 1415821-53-2
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-4-hydroxypiperidin-1-yl)prop-2-en-1-one
CAS 1415821-53-2C25H27N5O3
Evobrutinib chemical structure, C25H27N5O2, CAS 1415823-73-2
Evobrutinib
CAS 1415823-73-2C25H27N5O2
1-(4-(((2-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one chemical structure, C25H27N5O2, CAS 1415821-42-9
1-(4-(((2-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one
CAS 1415821-42-9C25H27N5O2
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-yn-1-one chemical structure, C25H25N5O2, CAS 1415821-62-3
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-yn-1-one
CAS 1415821-62-3C25H25N5O2
1-(4-(((6-Amino-5-(4-(4-hydroxyphenoxy)phenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one chemical structure, C25H27N5O3, CAS 1415822-13-7
1-(4-(((6-Amino-5-(4-(4-hydroxyphenoxy)phenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one
CAS 1415822-13-7C25H27N5O3
1-(4-(((6-Amino-5-(4-(p-tolyloxy)phenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one chemical structure, C26H29N5O2, CAS 1415822-17-1
1-(4-(((6-Amino-5-(4-(p-tolyloxy)phenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one
CAS 1415822-17-1C26H29N5O2
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-4-fluoropiperidin-1-yl)prop-2-en-1-one chemical structure, C25H26FN5O2, CAS 1415823-49-2
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-4-fluoropiperidin-1-yl)prop-2-en-1-one
CAS 1415823-49-2C25H26FN5O2
1-(4-(((5-(4-Phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one chemical structure, C25H26N4O2, CAS 1415824-52-0
1-(4-(((5-(4-Phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one
CAS 1415824-52-0C25H26N4O2
5-(4-Phenoxyphenyl)-N4-(piperidin-4-ylmethyl)pyrimidine-4,6-diamine hydrochloride chemical structure, C22H26ClN5O, CAS 2119574-73-9
5-(4-Phenoxyphenyl)-N4-(piperidin-4-ylmethyl)pyrimidine-4,6-diamine hydrochloride
CAS 2119574-73-9C22H26ClN5O
tert-Butyl 4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-3-hydroxypiperidine-1-carboxylate chemical structure, C27H33N5O4, CAS 2007908-63-4
tert-Butyl 4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-3-hydroxypiperidine-1-carboxylate
CAS 2007908-63-4C27H33N5O4
5-[4-(3-Fluorophenoxy)phenyl]-N4-(4-piperidinylmethyl)-4,6-pyrimidinediamine chemical structure, C22H24FN5O, CAS 2369985-75-9
5-[4-(3-Fluorophenoxy)phenyl]-N4-(4-piperidinylmethyl)-4,6-pyrimidinediamine
CAS 2369985-75-9C22H24FN5O
tert-Butyl 4-(((6-amino-5-(4-(3-fluorophenoxy)phenyl)pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate chemical structure, C27H32FN5O3, CAS 2369982-37-4
tert-Butyl 4-(((6-amino-5-(4-(3-fluorophenoxy)phenyl)pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate
CAS 2369982-37-4C27H32FN5O3
tert-Butyl 4-(((6-amino-5-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate chemical structure, C27H32FN5O3, CAS 2369982-35-2
tert-Butyl 4-(((6-amino-5-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate
CAS 2369982-35-2C27H32FN5O3
tert-Butyl 4-(((6-amino-5-(4-(p-tolyloxy)phenyl)pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate chemical structure, C28H35N5O3, CAS 2376053-51-7
tert-Butyl 4-(((6-amino-5-(4-(p-tolyloxy)phenyl)pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate
CAS 2376053-51-7C28H35N5O3
tert-Butyl 4-(((6-amino-5-(4-phenoxy-2-(trifluoromethyl)phenyl)pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate chemical structure, C28H32F3N5O3, CAS 2369984-08-5
tert-Butyl 4-(((6-amino-5-(4-phenoxy-2-(trifluoromethyl)phenyl)pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate
CAS 2369984-08-5C28H32F3N5O3
tert-Butyl 4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-4-hydroxypiperidine-1-carboxylate chemical structure, C27H33N5O4, CAS 2369985-54-4
tert-Butyl 4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-4-hydroxypiperidine-1-carboxylate
CAS 2369985-54-4C27H33N5O4