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Murcko scaffold

Ring system with 4 rings and 22 atoms

19 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
19
With full pages
3
Scaffold SMILES

O=c1c(=Cc2ccco2)sc2n1CN(c1ccccc1)CN=2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(=Cc2ccco2)sc2n1CN(c1ccccc1)CN=2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

(7Z)-7-[(5-Methylfuran-2-yl)methylidene]-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C17H14N4O4S, CAS 690695-63-7
(7Z)-7-[(5-Methylfuran-2-yl)methylidene]-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690695-63-7C17H14N4O4S
(7Z)-3-(3-Acetylphenyl)-7-[(5-iodofuran-2-yl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H14IN3O3S, CAS 380864-96-0
(7Z)-3-(3-Acetylphenyl)-7-[(5-iodofuran-2-yl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 380864-96-0C18H14IN3O3S
(7Z)-3-(4-Acetylphenyl)-7-[(5-iodofuran-2-yl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H14IN3O3S, CAS 380587-96-2
(7Z)-3-(4-Acetylphenyl)-7-[(5-iodofuran-2-yl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 380587-96-2C18H14IN3O3S
(7Z)-7-[(5-Iodofuran-2-yl)methylidene]-3-(4-methylphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C17H14IN3O2S, CAS 381209-46-7
(7Z)-7-[(5-Iodofuran-2-yl)methylidene]-3-(4-methylphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 381209-46-7C17H14IN3O2S
(7Z)-7-(Furan-2-ylmethylidene)-3-phenyl-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C16H13N3O2S, CAS 774197-03-4
(7Z)-7-(Furan-2-ylmethylidene)-3-phenyl-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 774197-03-4C16H13N3O2S
(7Z)-3-(4-Acetylphenyl)-7-(furan-2-ylmethylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H15N3O3S, CAS 381204-65-5
(7Z)-3-(4-Acetylphenyl)-7-(furan-2-ylmethylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 381204-65-5C18H15N3O3S
(7Z)-3-(3-Acetylphenyl)-7-(furan-2-ylmethylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H15N3O3S, CAS 6597-88-2
(7Z)-3-(3-Acetylphenyl)-7-(furan-2-ylmethylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 6597-88-2C18H15N3O3S
(7Z)-7-(Furan-2-ylmethylidene)-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C16H12N4O4S, CAS 380587-46-2
(7Z)-7-(Furan-2-ylmethylidene)-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 380587-46-2C16H12N4O4S
(7Z)-7-(Furan-2-ylmethylidene)-3-(4-methoxyphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C17H15N3O3S, CAS 381190-74-5
(7Z)-7-(Furan-2-ylmethylidene)-3-(4-methoxyphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 381190-74-5C17H15N3O3S
(7Z)-3-(3-Fluorophenyl)-7-[(5-iodofuran-2-yl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C16H11FIN3O2S, CAS 380551-79-1
(7Z)-3-(3-Fluorophenyl)-7-[(5-iodofuran-2-yl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 380551-79-1C16H11FIN3O2S
Ethyl 4-[(7Z)-7-(furan-2-ylmethylidene)-6-oxo-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-3-yl]benzoate chemical structure, C19H17N3O4S, CAS 380588-10-3
Ethyl 4-[(7Z)-7-(furan-2-ylmethylidene)-6-oxo-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-3-yl]benzoate
CAS 380588-10-3C19H17N3O4S
(7Z)-3-(3,5-Dimethylphenyl)-7-(furan-2-ylmethylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H17N3O2S, CAS 690694-18-9
(7Z)-3-(3,5-Dimethylphenyl)-7-(furan-2-ylmethylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690694-18-9C18H17N3O2S
(7Z)-3-(4-Fluorophenyl)-7-[(5-iodofuran-2-yl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C16H11FIN3O2S, CAS 690694-93-0
(7Z)-3-(4-Fluorophenyl)-7-[(5-iodofuran-2-yl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690694-93-0C16H11FIN3O2S
(7Z)-3-(3,4-Dimethylphenyl)-7-[(5-methylfuran-2-yl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C19H19N3O2S, CAS 690685-21-3
(7Z)-3-(3,4-Dimethylphenyl)-7-[(5-methylfuran-2-yl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690685-21-3C19H19N3O2S
(7Z)-7-[(5-Iodofuran-2-yl)methylidene]-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C16H11IN4O4S, CAS 380592-56-3
(7Z)-7-[(5-Iodofuran-2-yl)methylidene]-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 380592-56-3C16H11IN4O4S
(7Z)-3-(3-Fluorophenyl)-7-(furan-2-ylmethylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C16H12FN3O2S, CAS 381167-93-7
(7Z)-3-(3-Fluorophenyl)-7-(furan-2-ylmethylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 381167-93-7C16H12FN3O2S
(7Z)-3-(3-Bromophenyl)-7-(furan-2-ylmethylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C16H12BrN3O2S, CAS 488724-33-0
(7Z)-3-(3-Bromophenyl)-7-(furan-2-ylmethylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 488724-33-0C16H12BrN3O2S
(7Z)-7-(Furan-2-ylmethylidene)-3-(4-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C16H12N4O4S, CAS 380869-86-3
(7Z)-7-(Furan-2-ylmethylidene)-3-(4-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 380869-86-3C16H12N4O4S
(7Z)-7-[(5-Iodofuran-2-yl)methylidene]-3-(4-nitrophenyl)-3,4-dihydro-2H-[1,3]thiazolo[3,2-a][1,3,5]triazin-6(7H)-one chemical structure, C16H11IN4O4S, CAS 6601-87-2
(7Z)-7-[(5-Iodofuran-2-yl)methylidene]-3-(4-nitrophenyl)-3,4-dihydro-2H-[1,3]thiazolo[3,2-a][1,3,5]triazin-6(7H)-one
CAS 6601-87-2C16H11IN4O4S