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Murcko scaffold

Ring system with 3 rings and 21 atoms

23 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
23
With full pages
11
Scaffold SMILES

O=C1OC2(CCCCC2)OC(=O)C1=CNc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1OC2(CCCCC2)OC(=O)C1=CNc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

3-(((2,5-Dimethoxyphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C18H21NO6, CAS 384357-15-7
3-(((2,5-Dimethoxyphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 384357-15-7C18H21NO6
3-(((2-Methoxyphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C17H19NO5, CAS 384357-00-0
3-(((2-Methoxyphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 384357-00-0C17H19NO5
3-(((2-Chlorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C16H16ClNO4, CAS 135734-81-5
3-(((2-Chlorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 135734-81-5C16H16ClNO4
3-(((2-Fluorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C16H16FNO4, CAS 370855-04-2
3-(((2-Fluorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 370855-04-2C16H16FNO4
3-(((3-Methoxyphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C17H19NO5, CAS 369394-57-0
3-(((3-Methoxyphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 369394-57-0C17H19NO5
N-(4-{[(2,4-Dioxo-1,5-dioxaspiro[5.5]undec-3-ylidene)methyl]amino}phenyl)acetamide chemical structure, C18H20N2O5, CAS 370844-33-0
N-(4-{[(2,4-Dioxo-1,5-dioxaspiro[5.5]undec-3-ylidene)methyl]amino}phenyl)acetamide
CAS 370844-33-0C18H20N2O5
3-{[(3-Chloro-2-methylphenyl)amino]methylidene}-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C17H18ClNO4, CAS 370843-71-3
3-{[(3-Chloro-2-methylphenyl)amino]methylidene}-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 370843-71-3C17H18ClNO4
3-(((2,4-Difluorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C16H15F2NO4, CAS 369396-96-3
3-(((2,4-Difluorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 369396-96-3C16H15F2NO4
3-(((3,4-Difluorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C16H15F2NO4, CAS 369398-61-8
3-(((3,4-Difluorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 369398-61-8C16H15F2NO4
4-(((2,4-Dioxo-1,5-dioxaspiro[5.5]undecan-3-ylidene)methyl)amino)benzenesulfonamide chemical structure, C16H18N2O6S, CAS 370853-58-0
4-(((2,4-Dioxo-1,5-dioxaspiro[5.5]undecan-3-ylidene)methyl)amino)benzenesulfonamide
CAS 370853-58-0C16H18N2O6S
3-(((5-Chloro-2-methoxyphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C17H18ClNO5, CAS 370843-64-4
3-(((5-Chloro-2-methoxyphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 370843-64-4C17H18ClNO5
3-(((4-Chloro-2-(trifluoromethyl)phenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C17H15ClF3NO4, CAS 384357-95-3
3-(((4-Chloro-2-(trifluoromethyl)phenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 384357-95-3C17H15ClF3NO4
Ethyl 4-[({2,4-dioxo-1,5-dioxaspiro[5.5]undecan-3-ylidene}methyl)amino]benzoate chemical structure, C19H21NO6, CAS 370852-01-0
Ethyl 4-[({2,4-dioxo-1,5-dioxaspiro[5.5]undecan-3-ylidene}methyl)amino]benzoate
CAS 370852-01-0C19H21NO6
3-{[(4-Chloro-2,5-dimethoxyphenyl)amino]methylidene}-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C18H20ClNO6, CAS 370853-94-4
3-{[(4-Chloro-2,5-dimethoxyphenyl)amino]methylidene}-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 370853-94-4C18H20ClNO6
3-((o-Tolylamino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C17H19NO4, CAS 370848-29-6
3-((o-Tolylamino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 370848-29-6C17H19NO4
3-(((2-Nitrophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C16H16N2O6, CAS 135734-76-8
3-(((2-Nitrophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 135734-76-8C16H16N2O6
3-(((2-Methyl-4-nitrophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C17H18N2O6, CAS 370848-93-4
3-(((2-Methyl-4-nitrophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 370848-93-4C17H18N2O6
N-Carbamoyl-4-(((2,4-dioxo-1,5-dioxaspiro[5.5]undecan-3-ylidene)methyl)amino)benzenesulfonamide chemical structure, C17H19N3O7S, CAS 1105216-00-9
N-Carbamoyl-4-(((2,4-dioxo-1,5-dioxaspiro[5.5]undecan-3-ylidene)methyl)amino)benzenesulfonamide
CAS 1105216-00-9C17H19N3O7S
3-(((3-Fluorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C16H16FNO4, CAS 1105242-28-1
3-(((3-Fluorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 1105242-28-1C16H16FNO4
3-(((3-(Trifluoromethyl)phenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C17H16F3NO4, CAS 1105216-12-3
3-(((3-(Trifluoromethyl)phenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 1105216-12-3C17H16F3NO4
3-(((5-Fluoro-2-methylphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C17H18FNO4, CAS 1105242-32-7
3-(((5-Fluoro-2-methylphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 1105242-32-7C17H18FNO4
3-(((2-Fluoro-5-methylphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione chemical structure, C17H18FNO4, CAS 1105216-16-7
3-(((2-Fluoro-5-methylphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione
CAS 1105216-16-7C17H18FNO4
N-Carbamimidoyl-4-(((2,4-dioxo-1,5-dioxaspiro[5.5]undecan-3-ylidene)methyl)amino)benzenesulfonamide chemical structure, C17H20N4O6S, CAS 1170122-30-1
N-Carbamimidoyl-4-(((2,4-dioxo-1,5-dioxaspiro[5.5]undecan-3-ylidene)methyl)amino)benzenesulfonamide
CAS 1170122-30-1C17H20N4O6S