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Murcko scaffold

Ring system with 3 rings and 17 atoms

22 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
22
With full pages
11
Scaffold SMILES

c1ccc(-c2ncc(N3CCCCC3)o2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2ncc(N3CCCCC3)o2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

2-(4-Fluorophenyl)-5-(piperidin-1-yl)-1,3-oxazole-4-carbonitrile chemical structure, C15H14FN3O, CAS 442564-56-9
2-(4-Fluorophenyl)-5-(piperidin-1-yl)-1,3-oxazole-4-carbonitrile
CAS 442564-56-9C15H14FN3O
2-(4-Methoxyphenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile chemical structure, C16H17N3O2, CAS 307326-80-3
2-(4-Methoxyphenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile
CAS 307326-80-3C16H17N3O2
2-(3-Methylphenyl)-5-(4-methylpiperidin-1-yl)-1,3-oxazole-4-carbonitrile chemical structure, C17H19N3O, CAS 613652-14-5
2-(3-Methylphenyl)-5-(4-methylpiperidin-1-yl)-1,3-oxazole-4-carbonitrile
CAS 613652-14-5C17H19N3O
2-(2-Methylphenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile chemical structure, C16H17N3O, CAS 613650-81-0
2-(2-Methylphenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile
CAS 613650-81-0C16H17N3O
2-(3-Methylphenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile chemical structure, C16H17N3O, CAS 613651-15-3
2-(3-Methylphenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile
CAS 613651-15-3C16H17N3O
1-[2-(3-Chlorophenyl)-4-cyano-1,3-oxazol-5-yl]piperidine-4-carboxamide chemical structure, C16H15ClN4O2, CAS 844463-08-7
1-[2-(3-Chlorophenyl)-4-cyano-1,3-oxazol-5-yl]piperidine-4-carboxamide
CAS 844463-08-7C16H15ClN4O2
2-(4-Nitrophenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile chemical structure, C15H14N4O3, CAS 201992-49-6
2-(4-Nitrophenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile
CAS 201992-49-6C15H14N4O3
2-(2-Fluorophenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile chemical structure, C15H14FN3O, CAS 613652-02-1
2-(2-Fluorophenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile
CAS 613652-02-1C15H14FN3O
2-(4-Methoxyphenyl)-5-(4-methylpiperidin-1-yl)-1,3-oxazole-4-carbonitrile chemical structure, C17H19N3O2, CAS 613652-15-6
2-(4-Methoxyphenyl)-5-(4-methylpiperidin-1-yl)-1,3-oxazole-4-carbonitrile
CAS 613652-15-6C17H19N3O2
2-(4-tert-Butylphenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile chemical structure, C19H23N3O, CAS 710989-23-4
2-(4-tert-Butylphenyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile
CAS 710989-23-4C19H23N3O
2-(2,4-Dichlorophenyl)-4-diethoxyphosphoryl-5-piperidin-1-yl-1,3-oxazole chemical structure, C18H23Cl2N2O4P, CAS 201993-50-2
2-(2,4-Dichlorophenyl)-4-diethoxyphosphoryl-5-piperidin-1-yl-1,3-oxazole
CAS 201993-50-2C18H23Cl2N2O4P
1-[4-Cyano-2-(4-fluorophenyl)-1,3-oxazol-5-yl]piperidine-4-carboxamide chemical structure, C16H15FN4O2, CAS 729588-73-2
1-[4-Cyano-2-(4-fluorophenyl)-1,3-oxazol-5-yl]piperidine-4-carboxamide
CAS 729588-73-2C16H15FN4O2
5-(3,5-Dimethylpiperidin-1-yl)-2-(4-ethoxyphenyl)-1,3-oxazole-4-carbonitrile chemical structure, C19H23N3O2, CAS 613669-73-1
5-(3,5-Dimethylpiperidin-1-yl)-2-(4-ethoxyphenyl)-1,3-oxazole-4-carbonitrile
CAS 613669-73-1C19H23N3O2
2-(2-Chlorophenyl)-5-(3,5-dimethylpiperidin-1-yl)-1,3-oxazole-4-carbonitrile chemical structure, C17H18ClN3O, CAS 613651-69-7
2-(2-Chlorophenyl)-5-(3,5-dimethylpiperidin-1-yl)-1,3-oxazole-4-carbonitrile
CAS 613651-69-7C17H18ClN3O
5-(3,5-Dimethylpiperidin-1-yl)-2-(4-fluorophenyl)-1,3-oxazole-4-carbonitrile chemical structure, C17H18FN3O, CAS 613669-43-5
5-(3,5-Dimethylpiperidin-1-yl)-2-(4-fluorophenyl)-1,3-oxazole-4-carbonitrile
CAS 613669-43-5C17H18FN3O
2-(3,4-Dimethoxyphenyl)-5-(3,5-dimethylpiperidin-1-yl)-1,3-oxazole-4-carbonitrile chemical structure, C19H23N3O3, CAS 825600-36-0
2-(3,4-Dimethoxyphenyl)-5-(3,5-dimethylpiperidin-1-yl)-1,3-oxazole-4-carbonitrile
CAS 825600-36-0C19H23N3O3
4-(4-Cyano-5-(piperidin-1-yl)oxazol-2-yl)-N,N-dimethylbenzenesulfonamide chemical structure, C17H20N4O3S, CAS 941240-29-5
4-(4-Cyano-5-(piperidin-1-yl)oxazol-2-yl)-N,N-dimethylbenzenesulfonamide
CAS 941240-29-5C17H20N4O3S
4-[4-Cyano-5-(4-methylpiperidin-1-yl)-1,3-oxazol-2-yl]-N,N-dimethylbenzenesulfonamide chemical structure, C18H22N4O3S, CAS 941265-00-5
4-[4-Cyano-5-(4-methylpiperidin-1-yl)-1,3-oxazol-2-yl]-N,N-dimethylbenzenesulfonamide
CAS 941265-00-5C18H22N4O3S
1-{4-Cyano-2-[4-(dimethylsulfamoyl)phenyl]-1,3-oxazol-5-yl}piperidine-4-carboxamide chemical structure, C18H21N5O4S, CAS 941240-55-7
1-{4-Cyano-2-[4-(dimethylsulfamoyl)phenyl]-1,3-oxazol-5-yl}piperidine-4-carboxamide
CAS 941240-55-7C18H21N5O4S
4-(4-Cyano-5-(piperidin-1-yl)oxazol-2-yl)-N,N-diethylbenzenesulfonamide chemical structure, C19H24N4O3S, CAS 941242-86-0
4-(4-Cyano-5-(piperidin-1-yl)oxazol-2-yl)-N,N-diethylbenzenesulfonamide
CAS 941242-86-0C19H24N4O3S
4-(4-Cyano-5-(4-methylpiperidin-1-yl)oxazol-2-yl)-N,N-diethylbenzenesulfonamide chemical structure, C20H26N4O3S, CAS 941266-10-0
4-(4-Cyano-5-(4-methylpiperidin-1-yl)oxazol-2-yl)-N,N-diethylbenzenesulfonamide
CAS 941266-10-0C20H26N4O3S
1-(4-Cyano-2-(4-(N,N-diethylsulfamoyl)phenyl)oxazol-5-yl)piperidine-4-carboxamide chemical structure, C20H25N5O4S, CAS 941243-13-6
1-(4-Cyano-2-(4-(N,N-diethylsulfamoyl)phenyl)oxazol-5-yl)piperidine-4-carboxamide
CAS 941243-13-6C20H25N5O4S