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Murcko scaffold

Ring system with 4 rings and 28 atoms

14 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
14
With full pages
2
Scaffold SMILES

O=C(Cc1ccccc1)Nc1sc2c(c1C(=O)Nc1ccccc1)CCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cc1ccccc1)Nc1sc2c(c1C(=O)Nc1ccccc1)CCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

N-(2-Methylphenyl)-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H24N2O2S, CAS 304450-70-2
N-(2-Methylphenyl)-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 304450-70-2C24H24N2O2S
N-(4-Methoxyphenyl)-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H24N2O3S, CAS 312948-85-9
N-(4-Methoxyphenyl)-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 312948-85-9C24H24N2O3S
AG-667/11912004 chemical structure, C25H26N2O3S, CAS 5804-90-0
AG-667/11912004
CAS 5804-90-0C25H26N2O3S
N-(2-Methoxyphenyl)-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H24N2O3S, CAS 312948-84-8
N-(2-Methoxyphenyl)-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 312948-84-8C24H24N2O3S
2-{[(4-Methoxyphenyl)acetyl]amino}-N-(2-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C25H26N2O3S, CAS 292639-96-4
2-{[(4-Methoxyphenyl)acetyl]amino}-N-(2-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 292639-96-4C25H26N2O3S
N-(2-Ethoxyphenyl)-2-{[(4-methoxyphenyl)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C26H28N2O4S, CAS 312950-37-1
N-(2-Ethoxyphenyl)-2-{[(4-methoxyphenyl)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 312950-37-1C26H28N2O4S
N-(2-Chlorophenyl)-2-{[(4-methoxyphenyl)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H23ClN2O3S, CAS 304451-58-9
N-(2-Chlorophenyl)-2-{[(4-methoxyphenyl)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 304451-58-9C24H23ClN2O3S
N-(4-Methoxyphenyl)-6-methyl-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C25H26N2O3S, CAS 312949-04-5
N-(4-Methoxyphenyl)-6-methyl-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 312949-04-5C25H26N2O3S
6-Methyl-N-phenyl-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H24N2O2S, CAS 329067-68-7
6-Methyl-N-phenyl-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 329067-68-7C24H24N2O2S
N-(2-Methoxyphenyl)-6-methyl-2-[(2-phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C25H26N2O3S, CAS 329067-69-8
N-(2-Methoxyphenyl)-6-methyl-2-[(2-phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 329067-69-8C25H26N2O3S
N-(2-Ethoxyphenyl)-2-{[(4-methoxyphenyl)acetyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C27H30N2O4S, CAS 354769-08-7
N-(2-Ethoxyphenyl)-2-{[(4-methoxyphenyl)acetyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 354769-08-7C27H30N2O4S
N-(2,5-Dimethoxyphenyl)-2-{[(4-methoxyphenyl)acetyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C27H30N2O5S, CAS 433700-21-1
N-(2,5-Dimethoxyphenyl)-2-{[(4-methoxyphenyl)acetyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 433700-21-1C27H30N2O5S
N-(4-Ethoxyphenyl)-6-methyl-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C26H28N2O3S, CAS 312949-01-2
N-(4-Ethoxyphenyl)-6-methyl-2-[(phenylacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 312949-01-2C26H28N2O3S
2-{[(3,4-Diethoxyphenyl)acetyl]amino}-N-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C28H29F3N2O4S, CAS 522597-89-3
2-{[(3,4-Diethoxyphenyl)acetyl]amino}-N-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 522597-89-3C28H29F3N2O4S