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Murcko scaffold

4-Phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one scaffold

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
24
With full pages
10
Scaffold SMILES

O=C1CCCC2=C1C(c1ccccc1)NC(=S)N2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one page
Murcko scaffold O=C1CCCC2=C1C(c1ccccc1)NC(=S)N2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

4-(4-Fluorophenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C14H13FN2OS, CAS 294199-92-1
4-(4-Fluorophenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 294199-92-1C14H13FN2OS
4-(3-Hydroxyphenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one chemical structure, C14H14N2O2S, CAS 850916-11-9
4-(3-Hydroxyphenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one
CAS 850916-11-9C14H14N2O2S
4-(4-Ethylphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C18H22N2OS, CAS 850916-21-1
4-(4-Ethylphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 850916-21-1C18H22N2OS
4-(4-Methoxyphenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one chemical structure, C15H16N2O2S, CAS 223694-90-4
4-(4-Methoxyphenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one
CAS 223694-90-4C15H16N2O2S
4-(4-Chlorophenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one chemical structure, C14H13ClN2OS, CAS 223694-58-4
4-(4-Chlorophenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one
CAS 223694-58-4C14H13ClN2OS
4-(4-Bromophenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C14H13BrN2OS, CAS 223694-72-2
4-(4-Bromophenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 223694-72-2C14H13BrN2OS
4-(2-Methoxyphenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C15H16N2O2S, CAS 223694-84-6
4-(2-Methoxyphenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 223694-84-6C15H16N2O2S
4-(3-Nitrophenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C14H13N3O3S, CAS 300850-01-5
4-(3-Nitrophenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 300850-01-5C14H13N3O3S
4-(4-Isopropylphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C19H24N2OS, CAS 850916-18-6
4-(4-Isopropylphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 850916-18-6C19H24N2OS
7,7-Dimethyl-4-(2-methylphenyl)-2-sulfanylidene-3,4,6,8-tetrahydro-1H-quinazolin-5-one chemical structure, C17H20N2OS, CAS 850916-22-2
7,7-Dimethyl-4-(2-methylphenyl)-2-sulfanylidene-3,4,6,8-tetrahydro-1H-quinazolin-5-one
CAS 850916-22-2C17H20N2OS
4-(3-Fluorophenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one chemical structure, C14H13FN2OS, CAS 850916-14-2
4-(3-Fluorophenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one
CAS 850916-14-2C14H13FN2OS
4-(4-Methylphenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one chemical structure, C15H16N2OS, CAS 223694-81-3
4-(4-Methylphenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one
CAS 223694-81-3C15H16N2OS
4-(4-Ethoxyphenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C16H18N2O2S, CAS 850916-12-0
4-(4-Ethoxyphenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 850916-12-0C16H18N2O2S
4-(3-Fluorophenyl)-7,7-dimethyl-2-sulfanylidene-3,4,6,8-tetrahydro-1H-quinazolin-5-one chemical structure, C16H17FN2OS, CAS 850916-20-0
4-(3-Fluorophenyl)-7,7-dimethyl-2-sulfanylidene-3,4,6,8-tetrahydro-1H-quinazolin-5-one
CAS 850916-20-0C16H17FN2OS
4-(3-Methoxyphenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C15H16N2O2S, CAS 223694-87-9
4-(3-Methoxyphenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 223694-87-9C15H16N2O2S
4-(2-Chlorophenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C14H13ClN2OS, CAS 223694-51-7
4-(2-Chlorophenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 223694-51-7C14H13ClN2OS
4-(4-Ethylphenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C16H18N2OS, CAS 850916-15-3
4-(4-Ethylphenyl)-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 850916-15-3C16H18N2OS
2-Thioxo-4-(o-tolyl)-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C15H16N2OS, CAS 223694-75-5
2-Thioxo-4-(o-tolyl)-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 223694-75-5C15H16N2OS
4-Phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C14H14N2OS, CAS 223694-48-2
4-Phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 223694-48-2C14H14N2OS
4-(2-Methoxyphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C17H20N2O2S, CAS 433969-01-8
4-(2-Methoxyphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 433969-01-8C17H20N2O2S
4-(3-Bromophenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one chemical structure, C14H13BrN2OS, CAS 223694-67-5
4-(3-Bromophenyl)-2-sulfanylidene-1,3,4,6,7,8-hexahydroquinazolin-5-one
CAS 223694-67-5C14H13BrN2OS
7,7-Dimethyl-4-(4-methylphenyl)-2-sulfanylidene-3,4,6,8-tetrahydro-1H-quinazolin-5-one chemical structure, C17H20N2OS, CAS 433969-00-7
7,7-Dimethyl-4-(4-methylphenyl)-2-sulfanylidene-3,4,6,8-tetrahydro-1H-quinazolin-5-one
CAS 433969-00-7C17H20N2OS
4-(4-Fluorophenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one chemical structure, C16H17FN2OS, CAS 687572-44-7
4-(4-Fluorophenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
CAS 687572-44-7C16H17FN2OS
Dimethylenastron chemical structure, C16H18N2O2S, CAS 863774-58-7
Dimethylenastron
CAS 863774-58-7C16H18N2O2S