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Murcko scaffold

Ring system with 4 rings and 17 atoms

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
17
Chemicals
11
With full pages
4
Scaffold SMILES

c1ccc2c(c1)CCc1cn3nccc3nc1-2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc2c(c1)CCc1cn3nccc3nc1-2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

Methyl 7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxylate chemical structure, C17H12F3N3O2, CAS 313389-78-5
Methyl 7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxylate
CAS 313389-78-5C17H12F3N3O2
7-(Trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxamide chemical structure, C16H11F3N4O, CAS 334499-07-9
7-(Trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxamide
CAS 334499-07-9C16H11F3N4O
7-(Trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxylic acid chemical structure, C16H10F3N3O2, CAS 310451-85-5
7-(Trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxylic acid
CAS 310451-85-5C16H10F3N3O2
11-Chloro-7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxylic acid chemical structure, C16H9ClF3N3O2, CAS 312935-00-5
11-Chloro-7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxylic acid
CAS 312935-00-5C16H9ClF3N3O2
Isopropyl 7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxylate chemical structure, C19H16F3N3O2, CAS 351521-10-3
Isopropyl 7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxylate
CAS 351521-10-3C19H16F3N3O2
N-(Cyanomethyl)-7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxamide chemical structure, C18H12F3N5O, CAS 312934-95-5
N-(Cyanomethyl)-7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxamide
CAS 312934-95-5C18H12F3N5O
N-(tert-Butyl)-7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxamide chemical structure, C20H19F3N4O, CAS 351521-12-5
N-(tert-Butyl)-7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxamide
CAS 351521-12-5C20H19F3N4O
N-Isobutyl-7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxamide chemical structure, C20H19F3N4O, CAS 381695-76-7
N-Isobutyl-7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxamide
CAS 381695-76-7C20H19F3N4O
11-Chloro-N-(2-methoxyethyl)-7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxamide chemical structure, C19H16ClF3N4O2, CAS 352208-95-8
11-Chloro-N-(2-methoxyethyl)-7-(trifluoromethyl)-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-10-carboxamide
CAS 352208-95-8C19H16ClF3N4O2
3-Methoxy-10-methyl-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline chemical structure, C16H15N3O, CAS 866145-90-6
3-Methoxy-10-methyl-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline
CAS 866145-90-6C16H15N3O
3-Methoxy-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-11-carbonitrile chemical structure, C16H12N4O, CAS 866145-92-8
3-Methoxy-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-11-carbonitrile
CAS 866145-92-8C16H12N4O