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Murcko scaffold

Ring system with 3 rings and 29 atoms

26 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 29
Chemicals: 26
With full pages: 7

Scaffold SMILES

O=C(NCc1ccccc1)C(=O)NCC(c1cccs1)S(=O)(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NCc1ccccc1)C(=O)NCC(c1cccs1)S(=O)(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(3-methoxyphenyl)methyl]ethanediamide chemical structure, C22H22N2O5S2, CAS 896335-31-2

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(3-methoxyphenyl)methyl]ethanediamide

CAS 896335-31-2C₂₂H₂₂N₂O₅S₂

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(2-methoxyphenyl)methyl]ethanediamide chemical structure, C22H22N2O5S2, CAS 896336-60-0

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(2-methoxyphenyl)methyl]ethanediamide

CAS 896336-60-0C₂₂H₂₂N₂O₅S₂

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(2-chlorophenyl)methyl]ethanediamide chemical structure, C21H19ClN2O4S2, CAS 896337-70-5

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(2-chlorophenyl)methyl]ethanediamide

CAS 896337-70-5C₂₁H₁₉ClN₂O₄S₂

N1-(4-methylbenzyl)-N2-(2-(thiophen-2-yl)-2-tosylethyl)oxalamide chemical structure, C23H24N2O4S2, CAS 896339-40-5

N1-(4-methylbenzyl)-N2-(2-(thiophen-2-yl)-2-tosylethyl)oxalamide

CAS 896339-40-5C₂₃H₂₄N₂O₄S₂

N1-(4-chlorobenzyl)-N2-(2-(thiophen-2-yl)-2-tosylethyl)oxalamide chemical structure, C22H21ClN2O4S2, CAS 896339-48-3

N1-(4-chlorobenzyl)-N2-(2-(thiophen-2-yl)-2-tosylethyl)oxalamide

CAS 896339-48-3C₂₂H₂₁ClN₂O₄S₂

N1-(4-methoxybenzyl)-N2-(2-(thiophen-2-yl)-2-tosylethyl)oxalamide chemical structure, C23H24N2O5S2, CAS 896341-90-5

N1-(4-methoxybenzyl)-N2-(2-(thiophen-2-yl)-2-tosylethyl)oxalamide

CAS 896341-90-5C₂₃H₂₄N₂O₅S₂

N-[2-(4-Chlorobenzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(4-chlorophenyl)methyl]ethanediamide chemical structure, C21H18Cl2N2O4S2, CAS 896318-56-2

N-[2-(4-Chlorobenzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(4-chlorophenyl)methyl]ethanediamide

CAS 896318-56-2C₂₁H₁₈Cl₂N₂O₄S₂

N-[2-(4-Chlorobenzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(2-methylphenyl)methyl]ethanediamide chemical structure, C22H21ClN2O4S2, CAS 896325-36-3

N-[2-(4-Chlorobenzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(2-methylphenyl)methyl]ethanediamide

CAS 896325-36-3C₂₂H₂₁ClN₂O₄S₂

N-[2-(4-Fluorobenzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(4-methoxyphenyl)methyl]ethanediamide chemical structure, C22H21FN2O5S2, CAS 896328-20-4

N-[2-(4-Fluorobenzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(4-methoxyphenyl)methyl]ethanediamide

CAS 896328-20-4C₂₂H₂₁FN₂O₅S₂

N-[2-(4-Fluorobenzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(2-methoxyphenyl)methyl]ethanediamide chemical structure, C22H21FN2O5S2, CAS 896330-97-5

N-[2-(4-Fluorobenzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(2-methoxyphenyl)methyl]ethanediamide

CAS 896330-97-5C₂₂H₂₁FN₂O₅S₂

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(4-methylphenyl)methyl]ethanediamide chemical structure, C22H22N2O4S2, CAS 896331-30-9

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(4-methylphenyl)methyl]ethanediamide

CAS 896331-30-9C₂₂H₂₂N₂O₄S₂

N1-(2-((4-fluorophenyl)sulfonyl)-2-(thiophen-2-yl)ethyl)-N2-(4-methylbenzyl)oxalamide chemical structure, C22H21FN2O4S2, CAS 896326-00-4

N1-(2-((4-fluorophenyl)sulfonyl)-2-(thiophen-2-yl)ethyl)-N2-(4-methylbenzyl)oxalamide

CAS 896326-00-4C₂₂H₂₁FN₂O₄S₂

N1-(2-((4-fluorophenyl)sulfonyl)-2-(thiophen-2-yl)ethyl)-N2-(3-methoxybenzyl)oxalamide chemical structure, C22H21FN2O5S2, CAS 896329-86-5

N1-(2-((4-fluorophenyl)sulfonyl)-2-(thiophen-2-yl)ethyl)-N2-(3-methoxybenzyl)oxalamide

CAS 896329-86-5C₂₂H₂₁FN₂O₅S₂

N1-(2-fluorobenzyl)-N2-(2-((4-fluorophenyl)sulfonyl)-2-(thiophen-2-yl)ethyl)oxalamide chemical structure, C21H18F2N2O4S2, CAS 896332-94-8

N1-(2-fluorobenzyl)-N2-(2-((4-fluorophenyl)sulfonyl)-2-(thiophen-2-yl)ethyl)oxalamide

CAS 896332-94-8C₂₁H₁₈F₂N₂O₄S₂

N1-(4-chlorobenzyl)-N2-(2-(phenylsulfonyl)-2-(thiophen-2-yl)ethyl)oxalamide chemical structure, C21H19ClN2O4S2, CAS 896331-38-7

N1-(4-chlorobenzyl)-N2-(2-(phenylsulfonyl)-2-(thiophen-2-yl)ethyl)oxalamide

CAS 896331-38-7C₂₁H₁₉ClN₂O₄S₂

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(4-fluorophenyl)methyl]ethanediamide chemical structure, C21H19FN2O4S2, CAS 896332-83-5

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(4-fluorophenyl)methyl]ethanediamide

CAS 896332-83-5C₂₁H₁₉FN₂O₄S₂

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(4-methoxyphenyl)methyl]ethanediamide chemical structure, C22H22N2O5S2, CAS 896333-65-6

N-[2-(Benzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(4-methoxyphenyl)methyl]ethanediamide

CAS 896333-65-6C₂₂H₂₂N₂O₅S₂

N'-Benzyl-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide chemical structure, C22H22N2O4S2, CAS 896339-00-7

N'-Benzyl-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide

CAS 896339-00-7C₂₂H₂₂N₂O₄S₂

N'-[(4-Fluorophenyl)methyl]-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide chemical structure, C22H21FN2O4S2, CAS 896341-06-3

N'-[(4-Fluorophenyl)methyl]-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide

CAS 896341-06-3C₂₂H₂₁FN₂O₄S₂

N'-[(3-Methoxyphenyl)methyl]-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide chemical structure, C23H24N2O5S2, CAS 896343-70-7

N'-[(3-Methoxyphenyl)methyl]-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide

CAS 896343-70-7C₂₃H₂₄N₂O₅S₂

N'-[(2-Methoxyphenyl)methyl]-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide chemical structure, C23H24N2O5S2, CAS 896345-03-2

N'-[(2-Methoxyphenyl)methyl]-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide

CAS 896345-03-2C₂₃H₂₄N₂O₅S₂

N'-[(2-Chlorophenyl)methyl]-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide chemical structure, C22H21ClN2O4S2, CAS 896316-75-9

N'-[(2-Chlorophenyl)methyl]-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide

CAS 896316-75-9C₂₂H₂₁ClN₂O₄S₂

N'-[(2-Fluorophenyl)methyl]-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide chemical structure, C22H21FN2O4S2, CAS 896317-84-3

N'-[(2-Fluorophenyl)methyl]-N-[2-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)ethyl]ethanediamide

CAS 896317-84-3C₂₂H₂₁FN₂O₄S₂

N-[2-(4-Chlorobenzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(2-chlorophenyl)methyl]ethanediamide chemical structure, C21H18Cl2N2O4S2, CAS 896324-53-1

N-[2-(4-Chlorobenzenesulfonyl)-2-(thiophen-2-yl)ethyl]-N'-[(2-chlorophenyl)methyl]ethanediamide

CAS 896324-53-1C₂₁H₁₈Cl₂N₂O₄S₂