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Murcko scaffold

Ring system with 4 rings and 22 atoms

55 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
55
With full pages
4
Scaffold SMILES

O=C1CC(c2nc3ccccc3n2Cc2ccccc2)CN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2nc3ccccc3n2Cc2ccccc2)CN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

4-(1-Benzylbenzimidazol-2-yl)-1-prop-2-enylpyrrolidin-2-one chemical structure, C21H21N3O, CAS 838891-33-1
4-(1-Benzylbenzimidazol-2-yl)-1-prop-2-enylpyrrolidin-2-one
CAS 838891-33-1C21H21N3O
1-Allyl-4-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C21H19ClFN3O, CAS 876887-83-1
1-Allyl-4-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 876887-83-1C21H19ClFN3O
1-Allyl-4-(1-(3-methylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C22H23N3O, CAS 847239-59-2
1-Allyl-4-(1-(3-methylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 847239-59-2C22H23N3O
4-{1-[(2-Chlorophenyl)methyl]benzimidazol-2-yl}-1-prop-2-enylpyrrolidin-2-one chemical structure, C21H20ClN3O, CAS 876887-78-4
4-{1-[(2-Chlorophenyl)methyl]benzimidazol-2-yl}-1-prop-2-enylpyrrolidin-2-one
CAS 876887-78-4C21H20ClN3O
1-Allyl-4-(1-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C21H19Cl2N3O, CAS 876887-88-6
1-Allyl-4-(1-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 876887-88-6C21H19Cl2N3O
1-Allyl-4-(1-(3,4-dichlorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C21H19Cl2N3O, CAS 876887-98-8
1-Allyl-4-(1-(3,4-dichlorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 876887-98-8C21H19Cl2N3O
4-{1-[(4-Chlorophenyl)methyl]-1H-1,3-benzodiazol-2-yl}-1-(prop-2-en-1-yl)pyrrolidin-2-one chemical structure, C21H20ClN3O, CAS 876888-03-8
4-{1-[(4-Chlorophenyl)methyl]-1H-1,3-benzodiazol-2-yl}-1-(prop-2-en-1-yl)pyrrolidin-2-one
CAS 876888-03-8C21H20ClN3O
1-Allyl-4-(1-(4-(tert-butyl)benzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C25H29N3O, CAS 876888-08-3
1-Allyl-4-(1-(4-(tert-butyl)benzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 876888-08-3C25H29N3O
1-Allyl-4-(1-(2,5-dimethylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C23H25N3O, CAS 876888-13-0
1-Allyl-4-(1-(2,5-dimethylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 876888-13-0C23H25N3O
1-(Prop-2-en-1-yl)-4-{1-[(2,3,5,6-tetramethylphenyl)methyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one chemical structure, C25H29N3O, CAS 876888-18-5
1-(Prop-2-en-1-yl)-4-{1-[(2,3,5,6-tetramethylphenyl)methyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one
CAS 876888-18-5C25H29N3O
1-(tert-Butyl)-4-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C22H23ClFN3O, CAS 876888-71-0
1-(tert-Butyl)-4-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 876888-71-0C22H23ClFN3O
1-(tert-Butyl)-4-(1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C23H27N3O, CAS 876889-06-4
1-(tert-Butyl)-4-(1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 876889-06-4C23H27N3O
1-Allyl-4-(1-(2-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C21H20FN3O, CAS 874639-57-3
1-Allyl-4-(1-(2-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 874639-57-3C21H20FN3O
1-Allyl-4-(1-(2-methylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C22H23N3O, CAS 874639-60-8
1-Allyl-4-(1-(2-methylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 874639-60-8C22H23N3O
1-Allyl-4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C21H20FN3O, CAS 874639-67-5
1-Allyl-4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 874639-67-5C21H20FN3O
1-Allyl-4-(1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C22H23N3O, CAS 874637-58-8
1-Allyl-4-(1-(4-methylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 874637-58-8C22H23N3O
1-tert-Butyl-4-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-pyrrolidin-2-one chemical structure, C22H24ClN3O, CAS 876888-91-4
1-tert-Butyl-4-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-pyrrolidin-2-one
CAS 876888-91-4C22H24ClN3O
4-(1-Benzyl-1H-benzo[d]imidazol-2-yl)-1-(tert-butyl)pyrrolidin-2-one chemical structure, C22H25N3O, CAS 876888-76-5
4-(1-Benzyl-1H-benzo[d]imidazol-2-yl)-1-(tert-butyl)pyrrolidin-2-one
CAS 876888-76-5C22H25N3O
1-(tert-Butyl)-4-(1-(1-phenylethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C23H27N3O, CAS 887347-69-5
1-(tert-Butyl)-4-(1-(1-phenylethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 887347-69-5C23H27N3O
1-(tert-Butyl)-4-(1-(2-methylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C23H27N3O, CAS 878693-83-5
1-(tert-Butyl)-4-(1-(2-methylbenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 878693-83-5C23H27N3O
1-Allyl-4-(1-(3-chlorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C21H20ClN3O, CAS 878692-42-3
1-Allyl-4-(1-(3-chlorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 878692-42-3C21H20ClN3O
1-(Prop-2-en-1-yl)-4-(1-{[4-(propan-2-yl)phenyl]methyl}-1H-1,3-benzodiazol-2-yl)pyrrolidin-2-one chemical structure, C24H27N3O, CAS 878692-45-6
1-(Prop-2-en-1-yl)-4-(1-{[4-(propan-2-yl)phenyl]methyl}-1H-1,3-benzodiazol-2-yl)pyrrolidin-2-one
CAS 878692-45-6C24H27N3O
1-(tert-Butyl)-4-(1-(2-chlorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C22H24ClN3O, CAS 878693-86-8
1-(tert-Butyl)-4-(1-(2-chlorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 878693-86-8C22H24ClN3O
1-(tert-Butyl)-4-(1-(3-chlorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C22H24ClN3O, CAS 878693-90-4
1-(tert-Butyl)-4-(1-(3-chlorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 878693-90-4C22H24ClN3O