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Murcko scaffold

Ring system with 2 rings and 14 atoms

22 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
22
With full pages
5
Scaffold SMILES

O=C(Cn1cccn1)Nc1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1cccn1)Nc1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

2-Ethyl 4-methyl 5-({[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-3-methyl-2,4-thiophenedicarboxylate chemical structure, C17H17F4N3O5S, CAS 512808-63-8
2-Ethyl 4-methyl 5-({[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-3-methyl-2,4-thiophenedicarboxylate
CAS 512808-63-8C17H17F4N3O5S
Isopropyl 4,5-dimethyl-2-({[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-3-thiophenecarboxylate chemical structure, C17H20F3N3O3S, CAS 491831-89-1
Isopropyl 4,5-dimethyl-2-({[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-3-thiophenecarboxylate
CAS 491831-89-1C17H20F3N3O3S
Diethyl 3-methyl-5-({[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-2,4-thiophenedicarboxylate chemical structure, C18H20F3N3O5S, CAS 299406-48-7
Diethyl 3-methyl-5-({[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-2,4-thiophenedicarboxylate
CAS 299406-48-7C18H20F3N3O5S
Diethyl 5-({[4-bromo-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-3-methyl-2,4-thiophenedicarboxylate chemical structure, C18H19BrF3N3O5S, CAS 299406-74-9
Diethyl 5-({[4-bromo-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-3-methyl-2,4-thiophenedicarboxylate
CAS 299406-74-9C18H19BrF3N3O5S
Ethyl 4,5-dimethyl-2-[[2-(5-methyl-3-nitropyrazol-1-yl)acetyl]amino]thiophene-3-carboxylate chemical structure, C15H18N4O5S, CAS 355416-69-2
Ethyl 4,5-dimethyl-2-[[2-(5-methyl-3-nitropyrazol-1-yl)acetyl]amino]thiophene-3-carboxylate
CAS 355416-69-2C15H18N4O5S
Ethyl 4,5-dimethyl-2-[[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]thiophene-3-carboxylate chemical structure, C16H18F3N3O3S, CAS 357611-69-9
Ethyl 4,5-dimethyl-2-[[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]thiophene-3-carboxylate
CAS 357611-69-9C16H18F3N3O3S
Ethyl 2-[[2-(3,5-dimethyl-4-nitropyrazol-1-yl)acetyl]amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C16H20N4O5S, CAS 355805-21-9
Ethyl 2-[[2-(3,5-dimethyl-4-nitropyrazol-1-yl)acetyl]amino]-4,5-dimethylthiophene-3-carboxylate
CAS 355805-21-9C16H20N4O5S
Methyl 2-[[2-(4-bromo-5-methyl-3-nitropyrazol-1-yl)acetyl]amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C14H15BrN4O5S, CAS 512827-70-2
Methyl 2-[[2-(4-bromo-5-methyl-3-nitropyrazol-1-yl)acetyl]amino]-4,5-dimethylthiophene-3-carboxylate
CAS 512827-70-2C14H15BrN4O5S
2-[[2-[4-Bromo-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C15H16BrF3N4O2S, CAS 489407-24-1
2-[[2-[4-Bromo-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 489407-24-1C15H16BrF3N4O2S
Ethyl 2-[[2-(4-chloro-5-methyl-3-nitropyrazol-1-yl)acetyl]amino]-4-ethyl-5-methylthiophene-3-carboxylate chemical structure, C16H19ClN4O5S, CAS 489407-47-8
Ethyl 2-[[2-(4-chloro-5-methyl-3-nitropyrazol-1-yl)acetyl]amino]-4-ethyl-5-methylthiophene-3-carboxylate
CAS 489407-47-8C16H19ClN4O5S
Ethyl 2-[[2-[4-bromo-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C16H17BrF3N3O3S, CAS 355805-41-3
Ethyl 2-[[2-[4-bromo-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5-dimethylthiophene-3-carboxylate
CAS 355805-41-3C16H17BrF3N3O3S
Methyl 2-({[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C15H15F4N3O3S, CAS 512808-70-7
Methyl 2-({[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-4,5-dimethyl-3-thiophenecarboxylate
CAS 512808-70-7C15H15F4N3O3S
Diethyl 5-[[2-(3,5-dimethyl-4-nitropyrazol-1-yl)acetyl]amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C18H22N4O7S, CAS 351520-64-4
Diethyl 5-[[2-(3,5-dimethyl-4-nitropyrazol-1-yl)acetyl]amino]-3-methylthiophene-2,4-dicarboxylate
CAS 351520-64-4C18H22N4O7S
2-[[2-(3,5-Dimethyl-4-nitropyrazol-1-yl)acetyl]amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C14H17N5O4S, CAS 355805-19-5
2-[[2-(3,5-Dimethyl-4-nitropyrazol-1-yl)acetyl]amino]-4,5-dimethylthiophene-3-carboxamide
CAS 355805-19-5C14H17N5O4S
Diethyl 3-methyl-5-[[2-(5-methyl-3,4-dinitropyrazol-1-yl)acetyl]amino]thiophene-2,4-dicarboxylate chemical structure, C17H19N5O9S, CAS 345950-84-7
Diethyl 3-methyl-5-[[2-(5-methyl-3,4-dinitropyrazol-1-yl)acetyl]amino]thiophene-2,4-dicarboxylate
CAS 345950-84-7C17H19N5O9S
5-[2-[4-Bromo-3-(difluoromethyl)-5-methylpyrazol-1-yl]propanoylamino]-4-cyano-N,N,3-trimethylthiophene-2-carboxamide chemical structure, C17H18BrF2N5O2S, CAS 1005694-42-7
5-[2-[4-Bromo-3-(difluoromethyl)-5-methylpyrazol-1-yl]propanoylamino]-4-cyano-N,N,3-trimethylthiophene-2-carboxamide
CAS 1005694-42-7C17H18BrF2N5O2S
2-[[2-(3,5-Dimethyl-4-nitropyrazol-1-yl)acetyl]amino]-5-propan-2-ylthiophene-3-carboxamide chemical structure, C15H19N5O4S, CAS 494791-18-3
2-[[2-(3,5-Dimethyl-4-nitropyrazol-1-yl)acetyl]amino]-5-propan-2-ylthiophene-3-carboxamide
CAS 494791-18-3C15H19N5O4S
5-({2-[4-Chloro-3-(difluoromethyl)-5-methyl-1H-pyrazol-1-yl]propanoyl}amino)-4-cyano-N,N,3-trimethylthiophene-2-carboxamide chemical structure, C17H18ClF2N5O2S, CAS 1005636-14-5
5-({2-[4-Chloro-3-(difluoromethyl)-5-methyl-1H-pyrazol-1-yl]propanoyl}amino)-4-cyano-N,N,3-trimethylthiophene-2-carboxamide
CAS 1005636-14-5C17H18ClF2N5O2S
2-{[2-(4-Bromo-5-methyl-1H-pyrazol-1-yl)propanoyl]amino}-4,5-dimethylthiophene-3-carboxamide chemical structure, C14H17BrN4O2S, CAS 1005585-62-5
2-{[2-(4-Bromo-5-methyl-1H-pyrazol-1-yl)propanoyl]amino}-4,5-dimethylthiophene-3-carboxamide
CAS 1005585-62-5C14H17BrN4O2S
2-[4-Chloro-3-(difluoromethyl)-5-methyl-1H-pyrazol-1-yl]-N-(3-cyano-4,5-dimethylthiophen-2-yl)propanamide chemical structure, C15H15ClF2N4OS, CAS 1005638-03-8
2-[4-Chloro-3-(difluoromethyl)-5-methyl-1H-pyrazol-1-yl]-N-(3-cyano-4,5-dimethylthiophen-2-yl)propanamide
CAS 1005638-03-8C15H15ClF2N4OS
2-(4-Bromo-5-methyl-1H-pyrazol-1-yl)-N-(3-cyano-4,5-dimethylthiophen-2-yl)propanamide chemical structure, C14H15BrN4OS, CAS 1005640-18-5
2-(4-Bromo-5-methyl-1H-pyrazol-1-yl)-N-(3-cyano-4,5-dimethylthiophen-2-yl)propanamide
CAS 1005640-18-5C14H15BrN4OS
2-(4-Bromo-5-methyl-1H-pyrazol-1-yl)-N-(3-cyano-4-ethyl-5-methylthiophen-2-yl)propanamide chemical structure, C15H17BrN4OS, CAS 1005651-27-3
2-(4-Bromo-5-methyl-1H-pyrazol-1-yl)-N-(3-cyano-4-ethyl-5-methylthiophen-2-yl)propanamide
CAS 1005651-27-3C15H17BrN4OS