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Murcko scaffold

1H-Pyrazolo[3,4-b]pyridin-6-ol scaffold

173 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
173
With full pages
18
Scaffold SMILES

O=c1ccc2cn[nH]c2[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1H-Pyrazolo[3,4-b]pyridin-6-ol page
Murcko scaffold O=c1ccc2cn[nH]c2[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 173 chemicals

[1,3-Dimethyl-6-oxo-4-(trifluoromethyl)-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]acetic acid chemical structure, C11H10F3N3O3, CAS 937605-40-8
[1,3-Dimethyl-6-oxo-4-(trifluoromethyl)-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]acetic acid
CAS 937605-40-8C11H10F3N3O3
[4-(Difluoromethyl)-3-methyl-6-oxo-1-propyl-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]acetic acid chemical structure, C13H15F2N3O3, CAS 937605-48-6
[4-(Difluoromethyl)-3-methyl-6-oxo-1-propyl-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]acetic acid
CAS 937605-48-6C13H15F2N3O3
Methyl 2-(1,3-dimethyl-6-oxo-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-7(6H)-yl)acetate chemical structure, C12H12F3N3O3, CAS 1018051-93-8
Methyl 2-(1,3-dimethyl-6-oxo-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-7(6H)-yl)acetate
CAS 1018051-93-8C12H12F3N3O3
Methyl 2-(1-(2,2-difluoroethyl)-4-(difluoromethyl)-3-methyl-6-oxo-1H-pyrazolo[3,4-b]pyridin-7(6H)-yl)acetate chemical structure, C13H13F4N3O3, CAS 1018142-30-7
Methyl 2-(1-(2,2-difluoroethyl)-4-(difluoromethyl)-3-methyl-6-oxo-1H-pyrazolo[3,4-b]pyridin-7(6H)-yl)acetate
CAS 1018142-30-7C13H13F4N3O3
[1-(2,2-Difluoroethyl)-4-(difluoromethyl)-3-methyl-6-oxo-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]acetic acid chemical structure, C12H11F4N3O3, CAS 1018052-01-1
[1-(2,2-Difluoroethyl)-4-(difluoromethyl)-3-methyl-6-oxo-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]acetic acid
CAS 1018052-01-1C12H11F4N3O3
Methyl 2-(1-(2,2-difluoroethyl)-3-methyl-6-oxo-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-7(6H)-yl)acetate chemical structure, C13H12F5N3O3, CAS 1018142-58-9
Methyl 2-(1-(2,2-difluoroethyl)-3-methyl-6-oxo-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-7(6H)-yl)acetate
CAS 1018142-58-9C13H12F5N3O3
[1-(2,2-Difluoroethyl)-3-methyl-6-oxo-4-(trifluoromethyl)-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]acetic acid chemical structure, C12H10F5N3O3, CAS 1018052-55-5
[1-(2,2-Difluoroethyl)-3-methyl-6-oxo-4-(trifluoromethyl)-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]acetic acid
CAS 1018052-55-5C12H10F5N3O3
3-(2,3,4-Trimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl)propanoic acid chemical structure, C12H15N3O3, CAS 1018126-46-9
3-(2,3,4-Trimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl)propanoic acid
CAS 1018126-46-9C12H15N3O3
3-(2-Ethyl-4-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl)propanoic acid chemical structure, C12H15N3O3, CAS 1018163-76-2
3-(2-Ethyl-4-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl)propanoic acid
CAS 1018163-76-2C12H15N3O3
3-(2-Isopropyl-4-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl)propanoic acid chemical structure, C13H17N3O3, CAS 1018163-91-1
3-(2-Isopropyl-4-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl)propanoic acid
CAS 1018163-91-1C13H17N3O3
3-(3,4-Dimethyl-6-oxo-2-propyl-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid chemical structure, C14H19N3O3, CAS 1018126-69-6
3-(3,4-Dimethyl-6-oxo-2-propyl-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid
CAS 1018126-69-6C14H19N3O3
3-(2-Isopropyl-3,4-dimethyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid chemical structure, C14H19N3O3, CAS 1018164-02-7
3-(2-Isopropyl-3,4-dimethyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid
CAS 1018164-02-7C14H19N3O3
3-[4-(Difluoromethyl)-2-ethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid chemical structure, C12H13F2N3O3, CAS 1018164-06-1
3-[4-(Difluoromethyl)-2-ethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid
CAS 1018164-06-1C12H13F2N3O3
3-[4-(Difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid chemical structure, C12H13F2N3O3, CAS 1018126-77-6
3-[4-(Difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid
CAS 1018126-77-6C12H13F2N3O3
3-(2-Methyl-6-oxo-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid chemical structure, C11H10F3N3O3, CAS 1018126-81-2
3-(2-Methyl-6-oxo-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid
CAS 1018126-81-2C11H10F3N3O3
Methyl 3-(2-isopropyl-3,4-dimethyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoate chemical structure, C15H21N3O3, CAS 1018164-14-1
Methyl 3-(2-isopropyl-3,4-dimethyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoate
CAS 1018164-14-1C15H21N3O3
3-[4-(Difluoromethyl)-6-oxo-2-propyl-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid chemical structure, C13H15F2N3O3, CAS 1018126-85-6
3-[4-(Difluoromethyl)-6-oxo-2-propyl-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid
CAS 1018126-85-6C13H15F2N3O3
Methyl 3-(4-(difluoromethyl)-2-ethyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoate chemical structure, C13H15F2N3O3, CAS 1018126-89-0
Methyl 3-(4-(difluoromethyl)-2-ethyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoate
CAS 1018126-89-0C13H15F2N3O3
3-(4-(Difluoromethyl)-2-isopropyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid chemical structure, C13H15F2N3O3, CAS 1018164-22-1
3-(4-(Difluoromethyl)-2-isopropyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid
CAS 1018164-22-1C13H15F2N3O3
3-[2-Ethyl-6-oxo-4-(trifluoromethyl)-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid chemical structure, C12H12F3N3O3, CAS 1018126-93-6
3-[2-Ethyl-6-oxo-4-(trifluoromethyl)-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid
CAS 1018126-93-6C12H12F3N3O3
Methyl 3-(2-methyl-6-oxo-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoate chemical structure, C12H12F3N3O3, CAS 1018164-26-5
Methyl 3-(2-methyl-6-oxo-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoate
CAS 1018164-26-5C12H12F3N3O3
Methyl 3-(4-(difluoromethyl)-2-isopropyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoate chemical structure, C14H17F2N3O3, CAS 1018126-97-0
Methyl 3-(4-(difluoromethyl)-2-isopropyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoate
CAS 1018126-97-0C14H17F2N3O3
3-(4-(Difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid chemical structure, C14H17F2N3O3, CAS 1018164-30-1
3-(4-(Difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid
CAS 1018164-30-1C14H17F2N3O3
3-(2-Isopropyl-6-oxo-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid chemical structure, C13H14F3N3O3, CAS 1018127-01-9
3-(2-Isopropyl-6-oxo-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-7(6H)-yl)propanoic acid
CAS 1018127-01-9C13H14F3N3O3