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Murcko scaffold

Ring system with 5 rings and 28 atoms

36 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
28
Chemicals
36
With full pages
4
Scaffold SMILES

O=C1Nc2ccccc2C1=Cc1nc2ccccc2c(=O)n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1Nc2ccccc2C1=Cc1nc2ccccc2c(=O)n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

2-[(1-Ethyl-2-oxoindol-3-ylidene)methyl]-3-(2-methylphenyl)quinazolin-4-one chemical structure, C26H21N3O2, CAS 5806-46-2
2-[(1-Ethyl-2-oxoindol-3-ylidene)methyl]-3-(2-methylphenyl)quinazolin-4-one
CAS 5806-46-2C26H21N3O2
3-(4-Methoxyphenyl)-2-[(1-methyl-2-oxoindol-3-ylidene)methyl]quinazolin-4-one chemical structure, C25H19N3O3
3-(4-Methoxyphenyl)-2-[(1-methyl-2-oxoindol-3-ylidene)methyl]quinazolin-4-one
C25H19N3O3
2-[(1,2-Dihydro-1,5-dimethyl-2-oxo-3H-indol-3-ylidene)methyl]-3-(3-methoxyphenyl)-4(3H)-quinazolinone chemical structure, C26H21N3O3, CAS 309720-05-6
2-[(1,2-Dihydro-1,5-dimethyl-2-oxo-3H-indol-3-ylidene)methyl]-3-(3-methoxyphenyl)-4(3H)-quinazolinone
CAS 309720-05-6C26H21N3O3
2-[(1-Methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-(4-methylphenyl)-4(3H)-quinazolinone chemical structure, C25H19N3O2, CAS 304868-00-6
2-[(1-Methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-(4-methylphenyl)-4(3H)-quinazolinone
CAS 304868-00-6C25H19N3O2
2-[(E)-(5-Bromo-1-methyl-2-oxoindol-3-ylidene)methyl]-3-(4-methylphenyl)quinazolin-4-one chemical structure, C25H18BrN3O2, CAS 317842-30-1
2-[(E)-(5-Bromo-1-methyl-2-oxoindol-3-ylidene)methyl]-3-(4-methylphenyl)quinazolin-4-one
CAS 317842-30-1C25H18BrN3O2
2-[(E)-(5-Methyl-2-oxo-1-propyl-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-phenylquinazolin-4(3H)-one chemical structure, C27H23N3O2, CAS 5705-53-3
2-[(E)-(5-Methyl-2-oxo-1-propyl-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-phenylquinazolin-4(3H)-one
CAS 5705-53-3C27H23N3O2
2-[(Z)-(1-Methyl-2-oxoindol-3-ylidene)methyl]-3-(3-methylphenyl)quinazolin-4-one chemical structure, C25H19N3O2, CAS 331831-45-9
2-[(Z)-(1-Methyl-2-oxoindol-3-ylidene)methyl]-3-(3-methylphenyl)quinazolin-4-one
CAS 331831-45-9C25H19N3O2
2-[(E)-(1,5-Dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-(4-methoxyphenyl)quinazolin-4(3H)-one chemical structure, C26H21N3O3, CAS 5705-49-7
2-[(E)-(1,5-Dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-(4-methoxyphenyl)quinazolin-4(3H)-one
CAS 5705-49-7C26H21N3O3
2-[(Z)-(5-Bromo-1-methyl-2-oxoindol-3-ylidene)methyl]-3-phenylquinazolin-4-one chemical structure, C24H16BrN3O2, CAS 331424-96-5
2-[(Z)-(5-Bromo-1-methyl-2-oxoindol-3-ylidene)methyl]-3-phenylquinazolin-4-one
CAS 331424-96-5C24H16BrN3O2
3-(2-Nitrophenyl)-2-[(E)-(2-oxo-1-propylindol-3-ylidene)methyl]quinazolin-4-one chemical structure, C26H20N4O4, CAS 6150-74-9
3-(2-Nitrophenyl)-2-[(E)-(2-oxo-1-propylindol-3-ylidene)methyl]quinazolin-4-one
CAS 6150-74-9C26H20N4O4
2-[(E)-(1-Ethyl-2-oxoindol-3-ylidene)methyl]-3-(4-methylphenyl)quinazolin-4-one chemical structure, C26H21N3O2, CAS 1164469-83-3
2-[(E)-(1-Ethyl-2-oxoindol-3-ylidene)methyl]-3-(4-methylphenyl)quinazolin-4-one
CAS 1164469-83-3C26H21N3O2
2-[(E)-(1,5-Dimethyl-2-oxoindol-3-ylidene)methyl]-3-(4-methylphenyl)quinazolin-4-one chemical structure, C26H21N3O2, CAS 302795-66-0
2-[(E)-(1,5-Dimethyl-2-oxoindol-3-ylidene)methyl]-3-(4-methylphenyl)quinazolin-4-one
CAS 302795-66-0C26H21N3O2
6-Iodo-2-[(Z)-(1-methyl-2-oxoindol-3-ylidene)methyl]-3-phenylquinazolin-4-one chemical structure, C24H16IN3O2, CAS 1321757-35-0
6-Iodo-2-[(Z)-(1-methyl-2-oxoindol-3-ylidene)methyl]-3-phenylquinazolin-4-one
CAS 1321757-35-0C24H16IN3O2
2-[(E)-(1,5-Dimethyl-2-oxoindol-3-ylidene)methyl]-3-(3-methylphenyl)quinazolin-4-one chemical structure, C26H21N3O2, CAS 331831-47-1
2-[(E)-(1,5-Dimethyl-2-oxoindol-3-ylidene)methyl]-3-(3-methylphenyl)quinazolin-4-one
CAS 331831-47-1C26H21N3O2
2-[(1-Ethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-(4-methoxyphenyl)-4(3H)-quinazolinone chemical structure, C26H21N3O3, CAS 331831-52-8
2-[(1-Ethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-(4-methoxyphenyl)-4(3H)-quinazolinone
CAS 331831-52-8C26H21N3O3
3-(4-Methoxyphenyl)-2-[(Z)-(1-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]quinazolin-4(3H)-one chemical structure, C25H19N3O3, CAS 5806-41-7
3-(4-Methoxyphenyl)-2-[(Z)-(1-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]quinazolin-4(3H)-one
CAS 5806-41-7C25H19N3O3
3-(2-Methoxyphenyl)-2-[(Z)-(1-methyl-2-oxoindol-3-ylidene)methyl]quinazolin-4-one chemical structure, C25H19N3O3, CAS 364382-94-5
3-(2-Methoxyphenyl)-2-[(Z)-(1-methyl-2-oxoindol-3-ylidene)methyl]quinazolin-4-one
CAS 364382-94-5C25H19N3O3
2-[(Z)-(5-Bromo-2-oxo-1-propylindol-3-ylidene)methyl]-3-phenylquinazolin-4-one chemical structure, C26H20BrN3O2, CAS 334506-91-1
2-[(Z)-(5-Bromo-2-oxo-1-propylindol-3-ylidene)methyl]-3-phenylquinazolin-4-one
CAS 334506-91-1C26H20BrN3O2
2-[(Z)-(1-Methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-(4-methylphenyl)quinazolin-4(3H)-one chemical structure, C25H19N3O2
2-[(Z)-(1-Methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-(4-methylphenyl)quinazolin-4(3H)-one
C25H19N3O2
3-(4-Methylphenyl)-2-[(2-oxo-1-propyl-1,2-dihydro-3H-indol-3-ylidene)methyl]-4(3H)-quinazolinone chemical structure, C27H23N3O2, CAS 300804-68-6
3-(4-Methylphenyl)-2-[(2-oxo-1-propyl-1,2-dihydro-3H-indol-3-ylidene)methyl]-4(3H)-quinazolinone
CAS 300804-68-6C27H23N3O2
(E)-3-(4-Methoxyphenyl)-2-((2-oxo-1-propylindolin-3-ylidene)methyl)quinazolin-4(3H)-one chemical structure, C27H23N3O3, CAS 300394-22-3
(E)-3-(4-Methoxyphenyl)-2-((2-oxo-1-propylindolin-3-ylidene)methyl)quinazolin-4(3H)-one
CAS 300394-22-3C27H23N3O3
(E)-2-((1-Isopropyl-2-oxoindolin-3-ylidene)methyl)-3-(4-methoxyphenyl)quinazolin-4(3H)-one chemical structure, C27H23N3O3, CAS 368433-53-8
(E)-2-((1-Isopropyl-2-oxoindolin-3-ylidene)methyl)-3-(4-methoxyphenyl)quinazolin-4(3H)-one
CAS 368433-53-8C27H23N3O3
3-(4-Methoxyphenyl)-2-[(E)-(1-methyl-2-oxoindol-3-ylidene)methyl]quinazolin-4-one chemical structure, C25H19N3O3
3-(4-Methoxyphenyl)-2-[(E)-(1-methyl-2-oxoindol-3-ylidene)methyl]quinazolin-4-one
C25H19N3O3
2-[(Z)-(5-Bromo-2-oxo-1-propylindol-3-ylidene)methyl]-3-(4-methylphenyl)quinazolin-4-one chemical structure, C27H22BrN3O2, CAS 334506-92-2
2-[(Z)-(5-Bromo-2-oxo-1-propylindol-3-ylidene)methyl]-3-(4-methylphenyl)quinazolin-4-one
CAS 334506-92-2C27H22BrN3O2