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Murcko scaffold

Ring system with 2 rings and 13 atoms

24 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
24
With full pages
5
Scaffold SMILES

O=c1[nH][nH]cc1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH][nH]cc1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

2-[(3-Chlorophenyl)-(3-oxo-5-propyl-1,2-dihydropyrazol-4-yl)methyl]propanedinitrile chemical structure, C16H15ClN4O, CAS 384801-49-4
2-[(3-Chlorophenyl)-(3-oxo-5-propyl-1,2-dihydropyrazol-4-yl)methyl]propanedinitrile
CAS 384801-49-4C16H15ClN4O
2-[(3-Hydroxy-5-methyl-1H-pyrazol-4-yl)(2-methoxyphenyl)methyl]malononitrile chemical structure, C15H14N4O2, CAS 298217-16-0
2-[(3-Hydroxy-5-methyl-1H-pyrazol-4-yl)(2-methoxyphenyl)methyl]malononitrile
CAS 298217-16-0C15H14N4O2
4-(2,2-Dicyano-1-phenylethyl)-5-hydroxy-3-methyl-1H-pyrazole-1-carbothioamide chemical structure, C15H13N5OS, CAS 351419-60-8
4-(2,2-Dicyano-1-phenylethyl)-5-hydroxy-3-methyl-1H-pyrazole-1-carbothioamide
CAS 351419-60-8C15H13N5OS
4-Benzyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrazole-1-carboximidamide chemical structure, C12H14N4O, CAS 866133-89-3
4-Benzyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrazole-1-carboximidamide
CAS 866133-89-3C12H14N4O
4-[2,2-Dicyano-1-(2,3-dichlorophenyl)ethyl]-5-hydroxy-3-methyl-1H-pyrazole-1-carbothioamide chemical structure, C15H11Cl2N5OS, CAS 351419-65-3
4-[2,2-Dicyano-1-(2,3-dichlorophenyl)ethyl]-5-hydroxy-3-methyl-1H-pyrazole-1-carbothioamide
CAS 351419-65-3C15H11Cl2N5OS
4-[2,2-Dicyano-1-(4-nitrophenyl)ethyl]-5-hydroxy-3-methyl-1H-pyrazole-1-carbothioamide chemical structure, C15H12N6O3S, CAS 351419-59-5
4-[2,2-Dicyano-1-(4-nitrophenyl)ethyl]-5-hydroxy-3-methyl-1H-pyrazole-1-carbothioamide
CAS 351419-59-5C15H12N6O3S
4-[2,2-Dicyano-1-(4-methoxyphenyl)ethyl]-5-hydroxy-3-methyl-1H-pyrazole-1-carbothioamide chemical structure, C16H15N5O2S, CAS 351419-58-4
4-[2,2-Dicyano-1-(4-methoxyphenyl)ethyl]-5-hydroxy-3-methyl-1H-pyrazole-1-carbothioamide
CAS 351419-58-4C16H15N5O2S
2-[(4-Bromophenyl)(3-hydroxy-5-propyl-1H-pyrazol-4-yl)methyl]malononitrile chemical structure, C16H15BrN4O, CAS 384803-80-9
2-[(4-Bromophenyl)(3-hydroxy-5-propyl-1H-pyrazol-4-yl)methyl]malononitrile
CAS 384803-80-9C16H15BrN4O
4-Benzyl-1,2-dihydro-5-methyl-3H-pyrazol-3-one chemical structure, C11H12N2O, CAS 112701-03-8
4-Benzyl-1,2-dihydro-5-methyl-3H-pyrazol-3-one
CAS 112701-03-8C11H12N2O
4-Benzyl-5-(trifluoromethyl)-1,2-dihydropyrazol-3-one chemical structure, C11H9F3N2O, CAS 164296-08-6
4-Benzyl-5-(trifluoromethyl)-1,2-dihydropyrazol-3-one
CAS 164296-08-6C11H9F3N2O
4-(4-Ethylbenzyl)-5-(trifluoromethyl)-1H-pyrazole-3-ol chemical structure, C13H13F3N2O, CAS 152595-73-8
4-(4-Ethylbenzyl)-5-(trifluoromethyl)-1H-pyrazole-3-ol
CAS 152595-73-8C13H13F3N2O
1,2-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-methyl-3H-pyrazol-3-one chemical structure, C11H12N2O2, CAS 75999-01-8
1,2-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-methyl-3H-pyrazol-3-one
CAS 75999-01-8C11H12N2O2
4-(4-Isopropoxybenzyl)-5-methyl-1H-pyrazol-3(2H)-one chemical structure, C14H18N2O2, CAS 329044-14-6
4-(4-Isopropoxybenzyl)-5-methyl-1H-pyrazol-3(2H)-one
CAS 329044-14-6C14H18N2O2
1,2-Dihydro-4-[(2-fluoro-4-methoxyphenyl)methyl]-5-methyl-3H-pyrazol-3-one chemical structure, C12H13FN2O2, CAS 421592-73-6
1,2-Dihydro-4-[(2-fluoro-4-methoxyphenyl)methyl]-5-methyl-3H-pyrazol-3-one
CAS 421592-73-6C12H13FN2O2
1,2-Dihydro-4-[(3-fluoro-4-methylphenyl)methyl]-5-methyl-3H-pyrazol-3-one chemical structure, C12H13FN2O, CAS 421592-81-6
1,2-Dihydro-4-[(3-fluoro-4-methylphenyl)methyl]-5-methyl-3H-pyrazol-3-one
CAS 421592-81-6C12H13FN2O
1,2-Dihydro-4-[(3-fluoro-4-methoxyphenyl)methyl]-5-methyl-3H-pyrazol-3-one chemical structure, C12H13FN2O2, CAS 421592-65-6
1,2-Dihydro-4-[(3-fluoro-4-methoxyphenyl)methyl]-5-methyl-3H-pyrazol-3-one
CAS 421592-65-6C12H13FN2O2
3-Methyl-2-propan-2-yl-4-[(4-propan-2-yloxyphenyl)methyl]-1H-pyrazol-5-one chemical structure, C17H24N2O2, CAS 1028026-83-6
3-Methyl-2-propan-2-yl-4-[(4-propan-2-yloxyphenyl)methyl]-1H-pyrazol-5-one
CAS 1028026-83-6C17H24N2O2
4-(2-Chlorobenzyl)-3-methyl-1H-pyrazol-5-ol chemical structure, C11H11ClN2O, CAS 1211450-13-3
4-(2-Chlorobenzyl)-3-methyl-1H-pyrazol-5-ol
CAS 1211450-13-3C11H11ClN2O
1-Acetyl-5-methyl-4-{[4-(propan-2-yloxy)phenyl]methyl}-2,3-dihydro-1H-pyrazol-3-one chemical structure, C16H20N2O3, CAS 910054-64-7
1-Acetyl-5-methyl-4-{[4-(propan-2-yloxy)phenyl]methyl}-2,3-dihydro-1H-pyrazol-3-one
CAS 910054-64-7C16H20N2O3
4-[(4-Bromo-2-methyl-phenyl)methyl]-5-isopropyl-1H-pyrazol-3-ol chemical structure, C14H17BrN2O, CAS 661480-89-3
4-[(4-Bromo-2-methyl-phenyl)methyl]-5-isopropyl-1H-pyrazol-3-ol
CAS 661480-89-3C14H17BrN2O
5-Amino-4-(4-fluorobenzyl)-1H-pyrazol-3(2H)-one chemical structure, C10H10FN3O, CAS 874829-36-4
5-Amino-4-(4-fluorobenzyl)-1H-pyrazol-3(2H)-one
CAS 874829-36-4C10H10FN3O
4-(3-Fluorobenzyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C11H11FN2O, CAS 2270908-45-5
4-(3-Fluorobenzyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one
CAS 2270908-45-5C11H11FN2O
4-[(4-Fluorophenyl)methyl]-1,3-dimethyl-1H-pyrazol-5-ol chemical structure, C12H13FN2O, CAS 2137858-40-1
4-[(4-Fluorophenyl)methyl]-1,3-dimethyl-1H-pyrazol-5-ol
CAS 2137858-40-1C12H13FN2O
4-(Ethoxy(4-methoxyphenyl)methyl)-1-isopropyl-5-methyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C17H24N2O3, CAS 921212-85-3
4-(Ethoxy(4-methoxyphenyl)methyl)-1-isopropyl-5-methyl-1,2-dihydro-3H-pyrazol-3-one
CAS 921212-85-3C17H24N2O3