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Murcko scaffold

2-((5-Oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-phenylacetamide scaffold

286 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 18
Chemicals: 286
With full pages: 31

Scaffold SMILES

O=C(CSc1nncc(=O)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 2-((5-Oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-phenylacetamide page

Murcko scaffold O=C(CSc1nncc(=O)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 286 chemicals

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(3-chlorophenyl)acetamide chemical structure, C12H12ClN5O2S, CAS 540498-77-9

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(3-chlorophenyl)acetamide

CAS 540498-77-9C₁₂H₁₂ClN₅O₂S

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide chemical structure, C13H15N5O3S, CAS 328020-93-5

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide

CAS 328020-93-5C₁₃H₁₅N₅O₃S

2-((4-Amino-4,5-dihydro-6-methyl-5-oxo-1,2,4-triazin-3-yl)thio)-N-(2,4-dimethylphenyl)acetamide chemical structure, C14H17N5O2S, CAS 381716-93-4

2-((4-Amino-4,5-dihydro-6-methyl-5-oxo-1,2,4-triazin-3-yl)thio)-N-(2,4-dimethylphenyl)acetamide

CAS 381716-93-4C₁₄H₁₇N₅O₂S

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(4-ethoxyphenyl)acetamide chemical structure, C14H17N5O3S, CAS 380582-94-5

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(4-ethoxyphenyl)acetamide

CAS 380582-94-5C₁₄H₁₇N₅O₃S

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(3,4-dichlorophenyl)acetamide chemical structure, C12H11Cl2N5O2S, CAS 446266-78-0

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(3,4-dichlorophenyl)acetamide

CAS 446266-78-0C₁₂H₁₁Cl₂N₅O₂S

3-(4-Amino-3-((2-((4-chlorophenyl)amino)-2-oxoethyl)thio)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propanoic acid chemical structure, C14H14ClN5O4S, CAS 383370-59-0

3-(4-Amino-3-((2-((4-chlorophenyl)amino)-2-oxoethyl)thio)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propanoic acid

CAS 383370-59-0C₁₄H₁₄ClN₅O₄S

Methyl 4-[[2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]acetyl]amino]benzoate chemical structure, C14H15N5O4S, CAS 540772-28-9

Methyl 4-[[2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]acetyl]amino]benzoate

CAS 540772-28-9C₁₄H₁₅N₅O₄S

2-[(4-Amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(4-bromophenyl)acetamide chemical structure, C12H12BrN5O2S, CAS 869067-66-3

2-[(4-Amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(4-bromophenyl)acetamide

CAS 869067-66-3C₁₂H₁₂BrN₅O₂S

2-((4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-(5-chloro-2-methoxyphenyl)acetamide chemical structure, C13H14ClN5O3S, CAS 869067-69-6

2-((4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-(5-chloro-2-methoxyphenyl)acetamide

CAS 869067-69-6C₁₃H₁₄ClN₅O₃S

2-((4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-(2,5-dimethoxyphenyl)acetamide chemical structure, C14H17N5O4S, CAS 869067-72-1

2-((4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-(2,5-dimethoxyphenyl)acetamide

CAS 869067-72-1C₁₄H₁₇N₅O₄S

2-[(4-Amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C13H12F3N5O2S, CAS 869067-75-4

2-[(4-Amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamide

CAS 869067-75-4C₁₃H₁₂F₃N₅O₂S

2-[(4-Amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C13H12F3N5O2S, CAS 869067-76-5

2-[(4-Amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide

CAS 869067-76-5C₁₃H₁₂F₃N₅O₂S

N-(4-Acetylphenyl)-2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]acetamide chemical structure, C14H15N5O3S, CAS 869067-82-3

N-(4-Acetylphenyl)-2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]acetamide

CAS 869067-82-3C₁₄H₁₅N₅O₃S

2-((4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-(3-methoxyphenyl)acetamide chemical structure, C13H15N5O3S, CAS 522604-37-1

2-((4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-(3-methoxyphenyl)acetamide

CAS 522604-37-1C₁₃H₁₅N₅O₃S

2-((4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-mesitylacetamide chemical structure, C15H19N5O2S, CAS 728925-32-4

2-((4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-mesitylacetamide

CAS 728925-32-4C₁₅H₁₉N₅O₂S

N-(3-Acetylphenyl)-2-[(4-amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]acetamide chemical structure, C14H15N5O3S, CAS 733004-63-2

N-(3-Acetylphenyl)-2-[(4-amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]acetamide

CAS 733004-63-2C₁₄H₁₅N₅O₃S

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-[4-(propan-2-yl)phenyl]acetamide chemical structure, C15H19N5O2S, CAS 733004-64-3

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-[4-(propan-2-yl)phenyl]acetamide

CAS 733004-64-3C₁₅H₁₉N₅O₂S

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(2-methoxyphenyl)acetamide chemical structure, C13H15N5O3S, CAS 540772-33-6

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(2-methoxyphenyl)acetamide

CAS 540772-33-6C₁₃H₁₅N₅O₃S

3-[4-Amino-3-[2-(4-methoxyanilino)-2-oxoethyl]sulfanyl-5-oxo-1,2,4-triazin-6-yl]propanoic acid chemical structure, C15H17N5O5S, CAS 398997-42-7

3-[4-Amino-3-[2-(4-methoxyanilino)-2-oxoethyl]sulfanyl-5-oxo-1,2,4-triazin-6-yl]propanoic acid

CAS 398997-42-7C₁₅H₁₇N₅O₅S

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(4-chlorophenyl)acetamide chemical structure, C12H12ClN5O2S, CAS 540772-30-3

2-[(4-Amino-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]-N-(4-chlorophenyl)acetamide

CAS 540772-30-3C₁₂H₁₂ClN₅O₂S

2-[(4-Amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(3-chloro-4-methylphenyl)acetamide chemical structure, C13H14ClN5O2S, CAS 869067-68-5

2-[(4-Amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(3-chloro-4-methylphenyl)acetamide

CAS 869067-68-5C₁₃H₁₄ClN₅O₂S

2-[(4-Amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(4-nitrophenyl)acetamide chemical structure, C12H12N6O4S, CAS 727980-25-8

2-[(4-Amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(4-nitrophenyl)acetamide

CAS 727980-25-8C₁₂H₁₂N₆O₄S

3-(4-Amino-3-((2-((2-methoxyphenyl)amino)-2-oxoethyl)thio)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propanoic acid chemical structure, C15H17N5O5S, CAS 540771-29-7

3-(4-Amino-3-((2-((2-methoxyphenyl)amino)-2-oxoethyl)thio)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propanoic acid

CAS 540771-29-7C₁₅H₁₇N₅O₅S

3-(4-Amino-3-((2-((2,4-dimethylphenyl)amino)-2-oxoethyl)thio)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propanoic acid chemical structure, C16H19N5O4S, CAS 398997-43-8

3-(4-Amino-3-((2-((2,4-dimethylphenyl)amino)-2-oxoethyl)thio)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propanoic acid

CAS 398997-43-8C₁₆H₁₉N₅O₄S