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Murcko scaffold

1H-Pyrazolo(3,4-d)pyrimidin-4-one, 4,5-dihydro-5-benzyl-1-phenyl- scaffold

125 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 23
Chemicals: 125
With full pages: 3

Scaffold SMILES

O=c1c2cnn(-c3ccccc3)c2ncn1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1H-Pyrazolo(3,4-d)pyrimidin-4-one, 4,5-dihydro-5-benzyl-1-phenyl- page

Murcko scaffold O=c1c2cnn(-c3ccccc3)c2ncn1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 125 chemicals

1H-Pyrazolo(3,4-d)pyrimidin-4-one, 4,5-dihydro-5-benzyl-1-phenyl- chemical structure, C18H14N4O, CAS 75263-95-5

1H-Pyrazolo(3,4-d)pyrimidin-4-one, 4,5-dihydro-5-benzyl-1-phenyl-

CAS 75263-95-5C₁₈H₁₄N₄O

1-(4-Fluorophenyl)-5-[(2-fluorophenyl)methyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C18H12F2N4O, CAS 841211-13-0

1-(4-Fluorophenyl)-5-[(2-fluorophenyl)methyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one

CAS 841211-13-0C₁₈H₁₂F₂N₄O

5-(4-Chlorobenzyl)-1-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C19H15ClN4O, CAS 887216-51-5

5-(4-Chlorobenzyl)-1-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

CAS 887216-51-5C₁₉H₁₅ClN₄O

5-Benzyl-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H16N4O, CAS 895011-84-4

5-Benzyl-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895011-84-4C₁₉H₁₆N₄O

5-[(3-Fluorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H15FN4O, CAS 895011-91-3

5-[(3-Fluorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895011-91-3C₁₉H₁₅FN₄O

5-[(4-Fluorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H15FN4O, CAS 895011-98-0

5-[(4-Fluorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895011-98-0C₁₉H₁₅FN₄O

1-(2-Methylphenyl)-5-[(2-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C20H18N4O, CAS 895012-12-1

1-(2-Methylphenyl)-5-[(2-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one

CAS 895012-12-1C₂₀H₁₈N₄O

1-(2-Methylphenyl)-5-[(4-nitrophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H15N5O3, CAS 895012-19-8

1-(2-Methylphenyl)-5-[(4-nitrophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one

CAS 895012-19-8C₁₉H₁₅N₅O₃

1-(2-Methylphenyl)-5-[(3-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C20H18N4O, CAS 895012-26-7

1-(2-Methylphenyl)-5-[(3-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one

CAS 895012-26-7C₂₀H₁₈N₄O

5-[(2,5-Dimethylphenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C21H20N4O, CAS 895012-33-6

5-[(2,5-Dimethylphenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895012-33-6C₂₁H₂₀N₄O

1-(2-Methylphenyl)-5-[(4-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C20H18N4O, CAS 895012-40-5

1-(2-Methylphenyl)-5-[(4-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one

CAS 895012-40-5C₂₀H₁₈N₄O

1-(2-Methylphenyl)-5-[[3-(trifluoromethyl)phenyl]methyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C20H15F3N4O, CAS 895012-47-2

1-(2-Methylphenyl)-5-[[3-(trifluoromethyl)phenyl]methyl]pyrazolo[3,4-d]pyrimidin-4-one

CAS 895012-47-2C₂₀H₁₅F₃N₄O

1-(2-Methylphenyl)-5-[[4-(trifluoromethyl)phenyl]methyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C20H15F3N4O, CAS 895012-54-1

1-(2-Methylphenyl)-5-[[4-(trifluoromethyl)phenyl]methyl]pyrazolo[3,4-d]pyrimidin-4-one

CAS 895012-54-1C₂₀H₁₅F₃N₄O

5-[(2-Fluorophenyl)methyl]-1-(2-methylphenyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H15FN4O, CAS 895012-68-7

5-[(2-Fluorophenyl)methyl]-1-(2-methylphenyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one

CAS 895012-68-7C₁₉H₁₅FN₄O

1-(2-Methylphenyl)-5-[(3-nitrophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H15N5O3, CAS 895012-89-2

1-(2-Methylphenyl)-5-[(3-nitrophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one

CAS 895012-89-2C₁₉H₁₅N₅O₃

5-[(4-Bromophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H15BrN4O, CAS 895014-52-5

5-[(4-Bromophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895014-52-5C₁₉H₁₅BrN₄O

5-[(4-Chlorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H15ClN4O, CAS 895014-58-1

5-[(4-Chlorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895014-58-1C₁₉H₁₅ClN₄O

5-[(2-Chloro-6-fluorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H14ClFN4O, CAS 895014-64-9

5-[(2-Chloro-6-fluorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895014-64-9C₁₉H₁₄ClFN₄O

5-[(2-Chlorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H15ClN4O, CAS 895014-70-7

5-[(2-Chlorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895014-70-7C₁₉H₁₅ClN₄O

5-[(3,4-Dichlorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H14Cl2N4O, CAS 895014-77-4

5-[(3,4-Dichlorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895014-77-4C₁₉H₁₄Cl₂N₄O

5-[(3-Chlorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H15ClN4O, CAS 895014-84-3

5-[(3-Chlorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895014-84-3C₁₉H₁₅ClN₄O

5-[(2,4-Dichlorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C19H14Cl2N4O, CAS 895014-91-2

5-[(2,4-Dichlorophenyl)methyl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895014-91-2C₁₉H₁₄Cl₂N₄O

5-Benzyl-1-(3-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C18H13ClN4O, CAS 895017-83-1

5-Benzyl-1-(3-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-one

CAS 895017-83-1C₁₈H₁₃ClN₄O

1-(3-Chlorophenyl)-5-[(3-fluorophenyl)methyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C18H12ClFN4O, CAS 863416-52-8

1-(3-Chlorophenyl)-5-[(3-fluorophenyl)methyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one

CAS 863416-52-8C₁₈H₁₂ClFN₄O