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Murcko scaffold

Ring system with 3 rings and 16 atoms

42 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
42
With full pages
6
Scaffold SMILES

O=C1C=CC2(CC1)Oc1ccccc1C2=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C=CC2(CC1)Oc1ccccc1C2=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

Gris-peg chemical structure, C17H17ClO6, CAS 6915-11-3
Gris-peg
CAS 6915-11-3C17H17ClO6
7-Chloro-3',4,6-trimethoxyspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione chemical structure, C16H15ClO6, CAS 26194-86-5
7-Chloro-3',4,6-trimethoxyspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
CAS 26194-86-5C16H15ClO6
2'-Demethoxy-2'-methylgriseofulvin chemical structure, C17H17ClO5, CAS 127337-19-3
2'-Demethoxy-2'-methylgriseofulvin
CAS 127337-19-3C17H17ClO5
Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(methylthio)- chemical structure, C17H17ClO5S, CAS 26881-62-9
Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(methylthio)-
CAS 26881-62-9C17H17ClO5S
Griseofulvin chemical structure, C17H17ClO6, CAS 126-07-8
Griseofulvin
CAS 126-07-8C17H17ClO6
7-Chloro-4,6-dimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione chemical structure, C16H15ClO5, CAS 17793-62-3
7-Chloro-4,6-dimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
CAS 17793-62-3C16H15ClO5
Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 2',7-dichloro-4,6-dimethoxy-6'-methyl- chemical structure, C16H14Cl2O5, CAS 26881-56-1
Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 2',7-dichloro-4,6-dimethoxy-6'-methyl-
CAS 26881-56-1C16H14Cl2O5
7-Chloro-5'-hydroxy-2',4,6-trimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione chemical structure, C17H17ClO7, CAS 26110-46-3
7-Chloro-5'-hydroxy-2',4,6-trimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione
CAS 26110-46-3C17H17ClO7
(1'R,6'S)-Rel-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione chemical structure, C17H17ClO6, CAS 78739-00-1
(1'R,6'S)-Rel-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
CAS 78739-00-1C17H17ClO6
(+)-Epigriseofulvin chemical structure, C17H17ClO6, CAS 67890-77-1
(+)-Epigriseofulvin
CAS 67890-77-1C17H17ClO6
Epigriseofulvin chemical structure, C17H17ClO6, CAS 469-49-8
Epigriseofulvin
CAS 469-49-8C17H17ClO6
(1'S,6'S)-7-Chloro-2'-hydroxy-4,6-dimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione chemical structure, C16H15ClO6, CAS 136616-32-5
(1'S,6'S)-7-Chloro-2'-hydroxy-4,6-dimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione
CAS 136616-32-5C16H15ClO6
4-Demethylgriseofulvin chemical structure, C16H15ClO6, CAS 5128-41-6
4-Demethylgriseofulvin
CAS 5128-41-6C16H15ClO6
(1'S,6'R)-7-Chloro-6-hydroxy-2',4-dimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione chemical structure, C16H15ClO6, CAS 20168-88-1
(1'S,6'R)-7-Chloro-6-hydroxy-2',4-dimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione
CAS 20168-88-1C16H15ClO6
5-Chlorogriseofulvin chemical structure, C17H16Cl2O6, CAS 55555-63-0
5-Chlorogriseofulvin
CAS 55555-63-0C17H16Cl2O6
7-Chloro-2'-ethoxy-4,6-dimethoxy-6'-methyl-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione chemical structure, C18H19ClO6, CAS 3260-51-3
7-Chloro-2'-ethoxy-4,6-dimethoxy-6'-methyl-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
CAS 3260-51-3C18H19ClO6
7-Chloro-4,6-dimethoxy-6'-methyl-2'-(methylthio)-spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, cis-(+-)- chemical structure, C17H17ClO5S, CAS 187950-15-8
7-Chloro-4,6-dimethoxy-6'-methyl-2'-(methylthio)-spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, cis-(+-)-
CAS 187950-15-8C17H17ClO5S
7-Chloro-4,4',6-trimethoxy-6'-methyl-2',3-dioxospiro[1-benzofuran-2,5'-cyclohex-3-ene]-1'-carbaldehyde chemical structure, C18H17ClO7, CAS 25357-21-5
7-Chloro-4,4',6-trimethoxy-6'-methyl-2',3-dioxospiro[1-benzofuran-2,5'-cyclohex-3-ene]-1'-carbaldehyde
CAS 25357-21-5C18H17ClO7
7-Chloro-4,6-dimethoxy-6'-methyl-2'-(methylthio)-spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, trans-(+/-)- chemical structure, C17H17ClO5S, CAS 130423-14-2
7-Chloro-4,6-dimethoxy-6'-methyl-2'-(methylthio)-spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, trans-(+/-)-
CAS 130423-14-2C17H17ClO5S
4'-O-Demethyl griseofulvin chemical structure, C16H15ClO6, CAS 1158186-19-6
4'-O-Demethyl griseofulvin
CAS 1158186-19-6C16H15ClO6
7-Chloro-4,6-dimethoxy-6'-methyl-2'-propoxy-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione chemical structure, C19H21ClO6, CAS 65267-24-5
7-Chloro-4,6-dimethoxy-6'-methyl-2'-propoxy-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
CAS 65267-24-5C19H21ClO6
2'-Butoxy-7-chloro-4,6-dimethoxy-6'-methyl-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione chemical structure, C20H23ClO6, CAS 65267-26-7
2'-Butoxy-7-chloro-4,6-dimethoxy-6'-methyl-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
CAS 65267-26-7C20H23ClO6
7-Chloro-2',6-diethoxy-4-methoxy-6'-methyl-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione chemical structure, C19H21ClO6, CAS 98801-82-2
7-Chloro-2',6-diethoxy-4-methoxy-6'-methyl-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
CAS 98801-82-2C19H21ClO6
Dechlorogriseofulvin chemical structure, C17H18O6, CAS 3680-32-8
Dechlorogriseofulvin
CAS 3680-32-8C17H18O6