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Murcko scaffold

1',3'-Dihydrospiro[cyclohexane-1,2'-inden]-3'-one scaffold

23 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
23
With full pages
2
Scaffold SMILES

O=C1c2ccccc2CC12CCCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1',3'-Dihydrospiro[cyclohexane-1,2'-inden]-3'-one page
Murcko scaffold O=C1c2ccccc2CC12CCCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

Spirendolol chemical structure, C21H31NO3, CAS 65429-87-0
Spirendolol
CAS 65429-87-0C21H31NO3
LI 32-468 chemical structure, C21H31NO3, CAS 81840-58-6
LI 32-468
CAS 81840-58-6C21H31NO3
Spiro(cyclohexane-1,2'-(2H)inden)-1'(3'H)-one, 4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-, propanedioate (2:1) (salt) chemical structure, C45H66N2O10, CAS 65462-27-3
Spiro(cyclohexane-1,2'-(2H)inden)-1'(3'H)-one, 4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-, propanedioate (2:1) (salt)
CAS 65462-27-3C45H66N2O10
1',3'-Dihydrospiro[cyclohexane-1,2'-inden]-3'-one chemical structure, C14H16O, CAS 26673-29-0
1',3'-Dihydrospiro[cyclohexane-1,2'-inden]-3'-one
CAS 26673-29-0C14H16O
6'-Bromo-4-ethoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C16H19BrO2, CAS 1245515-77-8
6'-Bromo-4-ethoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1245515-77-8C16H19BrO2
6'-Bromo-4-hydroxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C14H15BrO2, CAS 1383985-06-5
6'-Bromo-4-hydroxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1383985-06-5C14H15BrO2
(1r,4r)-4,6'-Dimethoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C16H20O3, CAS 1245524-05-3
(1r,4r)-4,6'-Dimethoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1245524-05-3C16H20O3
6'-Bromo-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C15H17BrO2, CAS 1245515-16-5
6'-Bromo-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1245515-16-5C15H17BrO2
6'-Bromo-4,4-difluorospiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C14H13BrF2O, CAS 1245515-03-0
6'-Bromo-4,4-difluorospiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1245515-03-0C14H13BrF2O
6'-Bromo-4-hydroxy-4-methylspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C15H17BrO2, CAS 1430422-49-3
6'-Bromo-4-hydroxy-4-methylspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1430422-49-3C15H17BrO2
4-Hydroxy-6'-isobutoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C18H24O3, CAS 2089648-99-5
4-Hydroxy-6'-isobutoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 2089648-99-5C18H24O3
6'-Isobutoxy-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C19H26O3, CAS 2089648-67-7
6'-Isobutoxy-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 2089648-67-7C19H26O3
(1R,4R)-6'-Bromo-4-methoxy-4-methylspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C16H19BrO2, CAS 1383985-31-6
(1R,4R)-6'-Bromo-4-methoxy-4-methylspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1383985-31-6C16H19BrO2
6'-(3-Fluoropropoxy)-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C18H23FO3, CAS 1383985-35-0
6'-(3-Fluoropropoxy)-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1383985-35-0C18H23FO3
6'-Bromo-4-(difluoromethyl)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C15H15BrF2O, CAS 1383985-54-3
6'-Bromo-4-(difluoromethyl)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1383985-54-3C15H15BrF2O
(1R,4R)-4-Methoxy-6'-(3,3,3-trifluoropropoxy)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C18H21F3O3, CAS 1383985-48-5
(1R,4R)-4-Methoxy-6'-(3,3,3-trifluoropropoxy)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1383985-48-5C18H21F3O3
(1R,4R)-4-Hydroxy-6'-(3,3,3-trifluoropropoxy)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C17H19F3O3, CAS 1383985-47-4
(1R,4R)-4-Hydroxy-6'-(3,3,3-trifluoropropoxy)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1383985-47-4C17H19F3O3
6'-Bromo-4-(trifluoromethyl)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C15H14BrF3O, CAS 1383985-44-1
6'-Bromo-4-(trifluoromethyl)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1383985-44-1C15H14BrF3O
6'-(3-Fluoropropoxy)-4-hydroxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C17H21FO3, CAS 1383985-34-9
6'-(3-Fluoropropoxy)-4-hydroxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1383985-34-9C17H21FO3
Spirendolol, (R)- chemical structure, C21H31NO3, CAS 65451-86-7
Spirendolol, (R)-
CAS 65451-86-7C21H31NO3
(3'S,5'R)-6-Bromo-4'-methoxy-3',5'-dimethylspiro[3H-indene-2,1'-cyclohexane]-1-one chemical structure, C17H21BrO2, CAS 1454700-89-0
(3'S,5'R)-6-Bromo-4'-methoxy-3',5'-dimethylspiro[3H-indene-2,1'-cyclohexane]-1-one
CAS 1454700-89-0C17H21BrO2
4-Hydroxy-5'-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C15H18O3, CAS 1956331-55-7
4-Hydroxy-5'-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1956331-55-7C15H18O3
6'-Fluoro-4-hydroxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one chemical structure, C14H15FO2, CAS 1956386-13-2
6'-Fluoro-4-hydroxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-one
CAS 1956386-13-2C14H15FO2