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Murcko scaffold

Isoindole scaffold

65 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
65
With full pages
8
Scaffold SMILES

c1ccc2c[nH]cc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Isoindole page
Murcko scaffold c1ccc2c[nH]cc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

2-Methylisoindole chemical structure, C9H9N, CAS 33804-84-1
2-Methylisoindole
CAS 33804-84-1C9H9N
S-(2-(1-Carboxy-2-methylpropyl)isoindole-1-yl)-N-acetylcysteine chemical structure, C18H22N2O5S, CAS 126478-70-4
S-(2-(1-Carboxy-2-methylpropyl)isoindole-1-yl)-N-acetylcysteine
CAS 126478-70-4C18H22N2O5S
Phthalimide dioxime chemical structure, C8H7N3O2, CAS 4741-70-2
Phthalimide dioxime
CAS 4741-70-2C8H7N3O2
Methyl 2H-isoindole-1-carboxylate chemical structure, C10H9NO2, CAS 56365-71-0
Methyl 2H-isoindole-1-carboxylate
CAS 56365-71-0C10H9NO2
Methyl 2-methyl-2H-isoindole-1-carboxylate chemical structure, C11H11NO2, CAS 56365-72-1
Methyl 2-methyl-2H-isoindole-1-carboxylate
CAS 56365-72-1C11H11NO2
3-(Hydroxyamino)-1H-isoindol-1-one chemical structure, C8H6N2O2, CAS 29833-90-7
3-(Hydroxyamino)-1H-isoindol-1-one
CAS 29833-90-7C8H6N2O2
(2Z)-Amino(2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-ylidene)acetonitrile chemical structure, C11H9N3O, CAS 809230-43-1
(2Z)-Amino(2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-ylidene)acetonitrile
CAS 809230-43-1C11H9N3O
(1Z)-3-Amino-1H-isoindol-1-one hydrazone chemical structure, C8H8N4, CAS 40227-61-0
(1Z)-3-Amino-1H-isoindol-1-one hydrazone
CAS 40227-61-0C8H8N4
N'-Acetyl-2-methyl-1,3-dioxoisoindole-5-carbohydrazide chemical structure, C12H11N3O4, CAS 701255-36-9
N'-Acetyl-2-methyl-1,3-dioxoisoindole-5-carbohydrazide
CAS 701255-36-9C12H11N3O4
Isoindole chemical structure, C8H7N, CAS 270-68-8
Isoindole
CAS 270-68-8C8H7N
Guanidine, (2-(2-isoindolyl)ethyl)- chemical structure, C11H14N4, CAS 67227-00-3
Guanidine, (2-(2-isoindolyl)ethyl)-
CAS 67227-00-3C11H14N4
Bis(3-amino-4,5,6,7-tetrachloro-1H-isoindol-1-one oximato-N2,O1)nickel chemical structure, C8H3Cl4N3O, CAS 117989-29-4
Bis(3-amino-4,5,6,7-tetrachloro-1H-isoindol-1-one oximato-N2,O1)nickel
CAS 117989-29-4C8H3Cl4N3O
3-Chloro-2H-isoindole-1-carbaldehyde chemical structure, C9H6ClNO, CAS 22813-66-7
3-Chloro-2H-isoindole-1-carbaldehyde
CAS 22813-66-7C9H6ClNO
2-Methyl-2H-isoindole-1,3-diol chemical structure, C9H9NO2, CAS 768311-28-0
2-Methyl-2H-isoindole-1,3-diol
CAS 768311-28-0C9H9NO2
4,5,6,7-Tetrafluoro-2-methyl-2H-isoindole chemical structure, C9H5F4N, CAS 38053-09-7
4,5,6,7-Tetrafluoro-2-methyl-2H-isoindole
CAS 38053-09-7C9H5F4N
1,2,3-Trimethyl-2H-isoindole chemical structure, C11H13N, CAS 58083-43-5
1,2,3-Trimethyl-2H-isoindole
CAS 58083-43-5C11H13N
4,5,6,7-Tetrafluoro-2H-isoindole chemical structure, C8H3F4N, CAS 55164-85-7
4,5,6,7-Tetrafluoro-2H-isoindole
CAS 55164-85-7C8H3F4N
1-(tert-Butylsulfanyl)-2-propyl-2H-isoindole chemical structure, C15H21NS, CAS 64807-91-6
1-(tert-Butylsulfanyl)-2-propyl-2H-isoindole
CAS 64807-91-6C15H21NS
1-(Ethylsulfanyl)-2-propyl-2H-isoindole chemical structure, C13H17NS, CAS 61214-22-0
1-(Ethylsulfanyl)-2-propyl-2H-isoindole
CAS 61214-22-0C13H17NS
2-[(2-Propyl-2H-isoindol-1-yl)sulfanyl]ethan-1-ol chemical structure, C13H17NOS, CAS 61214-21-9
2-[(2-Propyl-2H-isoindol-1-yl)sulfanyl]ethan-1-ol
CAS 61214-21-9C13H17NOS
5-Bromo-2-methyl-2H-isoindole chemical structure, C9H8BrN, CAS 69189-32-8
5-Bromo-2-methyl-2H-isoindole
CAS 69189-32-8C9H8BrN
5-Fluoro-2-methyl-2H-isoindole chemical structure, C9H8FN, CAS 69189-20-4
5-Fluoro-2-methyl-2H-isoindole
CAS 69189-20-4C9H8FN
1-Ethyl-2-methyl-2H-isoindole chemical structure, C11H13N, CAS 58083-60-6
1-Ethyl-2-methyl-2H-isoindole
CAS 58083-60-6C11H13N
2-tert-Butyl-2H-isoindole chemical structure, C12H15N, CAS 55023-87-5
2-tert-Butyl-2H-isoindole
CAS 55023-87-5C12H15N