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Murcko scaffold

Ring system with 5 rings and 29 atoms

35 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
29
Chemicals
35
With full pages
10
Scaffold SMILES

O=c1oc2ccccc2cc1C(c1ccccc1)c1cc2ccccc2oc1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1oc2ccccc2cc1C(c1ccccc1)c1cc2ccccc2oc1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

3,3'-((4-Nitrophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) chemical structure, C25H15NO8, CAS 10172-70-0
3,3'-((4-Nitrophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
CAS 10172-70-0C25H15NO8
2H-1-Benzopyran-2-one, 3,3'-((4-methoxyphenyl)methylene)bis(4-hydroxy- chemical structure, C26H18O7, CAS 10172-75-5
2H-1-Benzopyran-2-one, 3,3'-((4-methoxyphenyl)methylene)bis(4-hydroxy-
CAS 10172-75-5C26H18O7
3,3'-(3,4,5-Trimethoxybenzylidene)bis(4-hydroxycoumarin) chemical structure, C28H22O9, CAS 15938-72-4
3,3'-(3,4,5-Trimethoxybenzylidene)bis(4-hydroxycoumarin)
CAS 15938-72-4C28H22O9
3,3'-((2-Fluorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) chemical structure, C25H15FO6, CAS 327107-19-7
3,3'-((2-Fluorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
CAS 327107-19-7C25H15FO6
3,3'-(4-Isopropylbenzylidene)bis(4-hydroxycoumarin) chemical structure, C28H22O6, CAS 200060-89-5
3,3'-(4-Isopropylbenzylidene)bis(4-hydroxycoumarin)
CAS 200060-89-5C28H22O6
4-Hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-hydroxyphenyl)methyl]-2H-chromen-2-one chemical structure, C25H16O7, CAS 10172-72-2
4-Hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-hydroxyphenyl)methyl]-2H-chromen-2-one
CAS 10172-72-2C25H16O7
3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-1-benzopyran-2-one) chemical structure, C25H15ClO6, CAS 4322-58-1
3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-1-benzopyran-2-one)
CAS 4322-58-1C25H15ClO6
3,3'-((4-Chlorophenyl)methylene)bis(4-hydroxy-2H-1-benzopyran-2-one) chemical structure, C25H15ClO6, CAS 4322-59-2
3,3'-((4-Chlorophenyl)methylene)bis(4-hydroxy-2H-1-benzopyran-2-one)
CAS 4322-59-2C25H15ClO6
3,3'-[(3-Methoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one) chemical structure, C26H18O7, CAS 10172-74-4
3,3'-[(3-Methoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
CAS 10172-74-4C26H18O7
3,3'-[(3-Fluorophenyl)methylene]bis(4-hydroxy-2H-1-benzopyran-2-one) chemical structure, C25H15FO6, CAS 6160-02-7
3,3'-[(3-Fluorophenyl)methylene]bis(4-hydroxy-2H-1-benzopyran-2-one)
CAS 6160-02-7C25H15FO6
3,3'-[(4-Ethylphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one) chemical structure, C27H20O6, CAS 329709-27-5
3,3'-[(4-Ethylphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
CAS 329709-27-5C27H20O6
4-Hydroxy-3-[(3-hydroxy-4-methoxyphenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one chemical structure, C26H18O8, CAS 10172-77-7
4-Hydroxy-3-[(3-hydroxy-4-methoxyphenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one
CAS 10172-77-7C26H18O8
3,3'-((4-Hydroxy-3-methoxyphenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) chemical structure, C26H18O8, CAS 13475-35-9
3,3'-((4-Hydroxy-3-methoxyphenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
CAS 13475-35-9C26H18O8
3-[(4-Bromophenyl)(4-hydroxy-2-oxochromen-3-yl)methyl]-4-hydroxychromen-2-one chemical structure, C25H15BrO6, CAS 17298-28-1
3-[(4-Bromophenyl)(4-hydroxy-2-oxochromen-3-yl)methyl]-4-hydroxychromen-2-one
CAS 17298-28-1C25H15BrO6
3,3'-Benzylidenebis(4-hydroxycoumarin) chemical structure, C25H16O6, CAS 1821-19-8
3,3'-Benzylidenebis(4-hydroxycoumarin)
CAS 1821-19-8C25H16O6
4-Hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-nitrophenyl)methyl]-2H-chromen-2-one chemical structure, C25H15NO8, CAS 64191-21-5
4-Hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-nitrophenyl)methyl]-2H-chromen-2-one
CAS 64191-21-5C25H15NO8
3-[(2,5-Dimethoxyphenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-4-hydroxy-2H-chromen-2-one chemical structure, C27H20O8, CAS 115604-02-9
3-[(2,5-Dimethoxyphenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-4-hydroxy-2H-chromen-2-one
CAS 115604-02-9C27H20O8
3,3'-[(2-Methoxyphenyl)methylene]bis[4-hydroxy-2H-1-benzopyran-2-one] chemical structure, C26H18O7, CAS 10172-73-3
3,3'-[(2-Methoxyphenyl)methylene]bis[4-hydroxy-2H-1-benzopyran-2-one]
CAS 10172-73-3C26H18O7
3,3'-((3,4-Dimethoxyphenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) chemical structure, C27H20O8, CAS 64191-24-8
3,3'-((3,4-Dimethoxyphenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
CAS 64191-24-8C27H20O8
3,3'-(p-Tolylmethylene)bis(4-hydroxy-2H-chromen-2-one) chemical structure, C26H18O6, CAS 23748-50-7
3,3'-(p-Tolylmethylene)bis(4-hydroxy-2H-chromen-2-one)
CAS 23748-50-7C26H18O6
3,3'-((4-(Dimethylamino)phenyl)methylene)bis(4,7-dihydroxy-2H-chromen-2-one) chemical structure, C27H21NO8, CAS 6265-51-6
3,3'-((4-(Dimethylamino)phenyl)methylene)bis(4,7-dihydroxy-2H-chromen-2-one)
CAS 6265-51-6C27H21NO8
2H-1-Benzopyran-2-one, 3,3'-(phenylmethylene)bis(6-hexyl-4,7-dihydroxy- chemical structure, C37H40O8, CAS 6322-95-8
2H-1-Benzopyran-2-one, 3,3'-(phenylmethylene)bis(6-hexyl-4,7-dihydroxy-
CAS 6322-95-8C37H40O8
3,3'-(4-(Dimethylamino)benzylidene)bis(4-hydroxycoumarin) chemical structure, C27H21NO6, CAS 10172-76-6
3,3'-(4-(Dimethylamino)benzylidene)bis(4-hydroxycoumarin)
CAS 10172-76-6C27H21NO6
2H-1-Benzopyran-2-one, 3,3'-((2,4-dimethoxyphenyl)methylene)bis(4-hydroxy- chemical structure, C27H20O8, CAS 10172-78-8
2H-1-Benzopyran-2-one, 3,3'-((2,4-dimethoxyphenyl)methylene)bis(4-hydroxy-
CAS 10172-78-8C27H20O8