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Murcko scaffold

Ring system with 3 rings and 18 atoms

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
10
With full pages
3
Scaffold SMILES

O=C1CCCc2c1ccc(=O)n2-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CCCc2c1ccc(=O)n2-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

7,7-Dimethyl-1-(4-methylphenyl)-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid chemical structure, C19H19NO4, CAS 799251-48-2
7,7-Dimethyl-1-(4-methylphenyl)-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid
CAS 799251-48-2C19H19NO4
Ethyl 2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydro-3-quinolinecarboxylate chemical structure, C18H17NO4, CAS 62370-70-1
Ethyl 2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydro-3-quinolinecarboxylate
CAS 62370-70-1C18H17NO4
N-Methyl-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide chemical structure, C17H16N2O3, CAS 354146-73-9
N-Methyl-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide
CAS 354146-73-9C17H16N2O3
2,5-Dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid chemical structure, C16H13NO4, CAS 125885-51-0
2,5-Dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid
CAS 125885-51-0C16H13NO4
Ethyl 7,7-dimethyl-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate chemical structure, C20H21NO4, CAS 62370-53-0
Ethyl 7,7-dimethyl-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate
CAS 62370-53-0C20H21NO4
2,5-Dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile chemical structure, C16H12N2O2, CAS 62370-50-7
2,5-Dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile
CAS 62370-50-7C16H12N2O2
2,5(1H,6H)-Quinolinedione, 7,8-dihydro-7,7-dimethyl-1-phenyl- chemical structure, C17H17NO2, CAS 62370-72-3
2,5(1H,6H)-Quinolinedione, 7,8-dihydro-7,7-dimethyl-1-phenyl-
CAS 62370-72-3C17H17NO2
1-(4-Fluorophenyl)-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid chemical structure, C16H12FNO4, CAS 933742-90-6
1-(4-Fluorophenyl)-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid
CAS 933742-90-6C16H12FNO4
C.I. Direct Brown 60 chemical structure, C17H16ClNO3, CAS 380634-57-1
C.I. Direct Brown 60
CAS 380634-57-1C17H16ClNO3
1-(4-Fluorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid chemical structure, C18H16FNO4, CAS 1134334-88-5
1-(4-Fluorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid
CAS 1134334-88-5C18H16FNO4