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Murcko scaffold

1-Phenyl-4-piperidinone scaffold

132 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
132
With full pages
15
Scaffold SMILES

O=C1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-4-piperidinone page
Murcko scaffold O=C1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 132 chemicals

Methyl 4-oxo-1-phenylpiperidine-3-carboxylate chemical structure, C13H15NO3, CAS 7501-80-6
Methyl 4-oxo-1-phenylpiperidine-3-carboxylate
CAS 7501-80-6C13H15NO3
1-Phenyl-4-piperidinone chemical structure, C11H13NO, CAS 19125-34-9
1-Phenyl-4-piperidinone
CAS 19125-34-9C11H13NO
Ethyl 4-oxo-1-phenylpiperidine-3-carboxylate chemical structure, C14H17NO3, CAS 1026-47-7
Ethyl 4-oxo-1-phenylpiperidine-3-carboxylate
CAS 1026-47-7C14H17NO3
1-(4-Fluorophenyl)-4-piperidinone chemical structure, C11H12FNO, CAS 116247-98-4
1-(4-Fluorophenyl)-4-piperidinone
CAS 116247-98-4C11H12FNO
1-(2-Nitrophenyl)piperidin-4-one chemical structure, C11H12N2O3, CAS 218610-21-0
1-(2-Nitrophenyl)piperidin-4-one
CAS 218610-21-0C11H12N2O3
1-(2-Fluoro-4-nitrophenyl)piperidin-4-one chemical structure, C11H11FN2O3, CAS 439097-58-2
1-(2-Fluoro-4-nitrophenyl)piperidin-4-one
CAS 439097-58-2C11H11FN2O3
1-(4-Nitrophenyl)piperidin-4-one chemical structure, C11H12N2O3, CAS 23499-01-6
1-(4-Nitrophenyl)piperidin-4-one
CAS 23499-01-6C11H12N2O3
1-[2,6-Dinitro-4-(trifluoromethyl)phenyl]tetrahydro-4(1H)-pyridinone chemical structure, C12H10F3N3O5, CAS 338757-95-2
1-[2,6-Dinitro-4-(trifluoromethyl)phenyl]tetrahydro-4(1H)-pyridinone
CAS 338757-95-2C12H10F3N3O5
1-(4-Methylphenyl)piperidin-4-one chemical structure, C12H15NO, CAS 105123-89-5
1-(4-Methylphenyl)piperidin-4-one
CAS 105123-89-5C12H15NO
4-(4-Oxopiperidin-1-yl)benzamide chemical structure, C12H14N2O2, CAS 340756-87-8
4-(4-Oxopiperidin-1-yl)benzamide
CAS 340756-87-8C12H14N2O2
1-[4-(Dimethylamino)phenyl]piperidin-4-one chemical structure, C13H18N2O, CAS 370885-30-6
1-[4-(Dimethylamino)phenyl]piperidin-4-one
CAS 370885-30-6C13H18N2O
4-(4-Oxopiperidin-1-yl)benzonitrile chemical structure, C12H12N2O, CAS 79421-46-8
4-(4-Oxopiperidin-1-yl)benzonitrile
CAS 79421-46-8C12H12N2O
1-[3-(Trifluoromethyl)phenyl]-4-piperidinone chemical structure, C12H12F3NO, CAS 147378-74-3
1-[3-(Trifluoromethyl)phenyl]-4-piperidinone
CAS 147378-74-3C12H12F3NO
1-(2-Fluorophenyl)piperidin-4-one chemical structure, C11H12FNO, CAS 115012-46-9
1-(2-Fluorophenyl)piperidin-4-one
CAS 115012-46-9C11H12FNO
1-(3-Chloro-4-methoxyphenyl)-4-piperidone chemical structure, C12H14ClNO2, CAS 250718-96-8
1-(3-Chloro-4-methoxyphenyl)-4-piperidone
CAS 250718-96-8C12H14ClNO2
Ethyl 4-(4-oxopiperidin-1-yl)benzoate chemical structure, C14H17NO3, CAS 25437-95-0
Ethyl 4-(4-oxopiperidin-1-yl)benzoate
CAS 25437-95-0C14H17NO3
4-(4-Oxo-1-piperidinyl)benzaldehyde chemical structure, C12H13NO2, CAS 79421-47-9
4-(4-Oxo-1-piperidinyl)benzaldehyde
CAS 79421-47-9C12H13NO2
1-(4-Acetylphenyl)piperidin-4-one chemical structure, C13H15NO2, CAS 79421-48-0
1-(4-Acetylphenyl)piperidin-4-one
CAS 79421-48-0C13H15NO2
1-(4-Methanesulfonylphenyl)piperidin-4-one chemical structure, C12H15NO3S, CAS 116248-04-5
1-(4-Methanesulfonylphenyl)piperidin-4-one
CAS 116248-04-5C12H15NO3S
1-(4-Chlorophenyl)piperidin-4-one chemical structure, C11H12ClNO, CAS 113759-96-9
1-(4-Chlorophenyl)piperidin-4-one
CAS 113759-96-9C11H12ClNO
2-(4-Oxo-piperidin-1-yl)-benzonitrile chemical structure, C12H12N2O, CAS 120807-28-5
2-(4-Oxo-piperidin-1-yl)-benzonitrile
CAS 120807-28-5C12H12N2O
1-(2-Methyl-4-nitrophenyl)piperidin-4-one chemical structure, C12H14N2O3, CAS 1094646-16-8
1-(2-Methyl-4-nitrophenyl)piperidin-4-one
CAS 1094646-16-8C12H14N2O3
1-(3-Chlorophenyl)piperidin-4-one chemical structure, C11H12ClNO, CAS 115012-58-3
1-(3-Chlorophenyl)piperidin-4-one
CAS 115012-58-3C11H12ClNO
1-(3-Nitrophenyl)piperidin-4-one chemical structure, C11H12N2O3, CAS 934746-61-9
1-(3-Nitrophenyl)piperidin-4-one
CAS 934746-61-9C11H12N2O3